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Jeffrey A. Weiss

From EverybodyWiki Bios & Wiki



Jeffrey A. Weiss is a Professor in the Department of Biomedical Engineering at the University of Utah. His research focuses on computational biomechanics, musculoskeletal mechanics, and angiogenesis.[1][2].

Education[edit]

Career and research[edit]

Ligament and Tendon Mechanics

Weiss’ research career began with the study of the structure, function, injury, and healing of ligaments and tendons. During his MS, he demonstrated that injuries to ligament insertion sites heal more slowly than injuries to the bulk of the ligament due to osteoclast resorption at the mineralization front [4]. At the University of Utah, his team established the role of non-collagenous components of the extracellular matrix in the multiaxial mechanical behavior of ligaments and tendons [5][6][7]. Notably, they established elastin as the main component which resists shear and transverse loading in ligaments and tendons [8][9].

In 2015 Weiss and Michael Yu, PhD, started a collaboration in which collagen hybridizing peptides (CHP’s) were used to study injury and remodeling of dense, collagenous tissues. Their experiments and simulations showed that the primary mechanism of damage accumulation and failure in collagenous tissues is the unraveling of the collagen triple helix [10]. This work has been used to develop new assays for collagen denaturation and to examine the mechanisms of tissue damage which lead to overuse injuries [11][12][13].

Computational Biomechanics

Weiss’ work with computational biomechanics started with his PhD dissertation in the early 1990’s in which he developed and implemented finite element code for constitutive models of soft tissue[14][15][16]. Since 2005, Weiss has collaborated with Gerard Ateshian, PhD, to develop and distribute FEBio (Finite Elements for Biomechanics and Biophysics) [17]. The software uses mixture theory to unify thermodynamics, solid mechanics, fluid mechanics, mass transport, chemical reactions, and electrokinetics [18]. Since its release in 2007, FEBio has gained popularity among biomedical scientists with over 13,000 registered users and 60,000 downloads. [19]

Osteoarthritis

Starting in 2001, Weiss and Chris Peters, PhD, began a collaboration to study the role of bony pathology in the hip on the premature development of osteoarthritis. To address the issue, they employed patient-specific finite element models [20][21]. This research was the first to demonstrate that overload of the acetabular labrum was the defining mechanical characteristic of the dysplastic hip [22][23]. Furthermore, this finding explained the occurrence of labral tears and an “outside-in” pattern of cartilage damage in osteoarthritic, dysplastic hips [24].

Angiogenesis

Since 1999, Weiss has collaborated with James Hoying, PhD, to study the mechanics which modulate angiogenesis [25]. They showed that matrix strain, effective matrix stiffness, and the matrix strain on collagen fibril alignment modulate neovascularization [26][27][28]. His group designed and validated a computational framework known as AngioFE to study angiogenic growth [29][30]. This in silico framework predicts the effects of mechanical conditions on neovascularization and matrix deformations [31]. Some of Weiss’ current work is to extend the modeling framework to include spatiotemporal cytokine gradients and the role of VEGF in neovessel guidance [32]

Selected awards and honors[edit]

  • University of Utah Distinguished Scholarly and Creative Research Award (2021) [33]
  • Fellow, ASME (12/01/2017) [34]
  • ASME Van C. Mow Medal (2013)[35]
  • Fellow, AIMBE (2006) [36]
  • ASME Y-C. Fung Award (2002)[37]
  • NSF CAREER Award (2002)[38]

References[edit]

  1. ↑ "Dr. Jeffrey Weiss - SCI Faculty Member" . The Scientific Computing & Imaging Institute. Retrieved 29 April 2021.
  2. ↑ "Jeff Weiss and Lowell Edgar, University of Utah (IMAGE)" . EurekAlert. Retrieved 29 April 2021
  3. ↑ "Jeffrey A. Weiss, Ph.D." . Orthopaedic Biomechanics Lab. Retrieved 29 April 2021.
  4. ↑ Weiss JA, Woo SL, Ohland KJ, Horibe S, Newton PO: Evaluation of a new injury model to study medial collateral ligament healing: primary repair versus nonoperative treatment. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 9(4): 516-528, 1991, PMCID.
  5. ↑ Henninger HB, Maas SA, Shepherd JH, Joshi S, Weiss JA: Transversely isotropic distribution of sulfated glycosaminoglycans in human medial collateral ligament: a quantitative analysis. Journal of structural biology, 165(3): 176-183, 2009, PMCID: PMC2649716.
  6. ↑ Lujan TJ, Underwood CJ, Henninger HB, Thompson BM, Weiss JA: Effect of dermatan sulfate glycosaminoglycans on the quasi-static material properties of the human medial collateral ligament. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 25(7): 894-903, 2007, PMCID.
  7. ↑ Reese SP, Underwood CJ, Weiss JA: Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels. Matrix biology : journal of the International Society for Matrix Biology, 2013, PMCID: PMC3795835.
  8. ↑ Henninger HB, Underwood CJ, Romney SJ, Davis GL, Weiss JA: Effect of elastin digestion on the quasi-static tensile response of medial collateral ligament. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8): 1226-1233, 2013, PMCID: PMC4112956.
  9. ↑ Henninger HB, Valdez WR, Scott SA, Weiss JA: Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading. Acta biomaterialia, 25: 304-312, 2015, PMCID: PMC4629914.
  10. ↑ Zitnay JL, Li Y, Qin Z, San BH, Depalle B, Reese SP, Buehler MJ, Yu SM, Weiss JA: Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides. Nature communications, 8: 14913, 2017, PMCID: PMC5364439 authors have no competing interests to declare.
  11. ↑ Lin AH, Allan AN, Zitnay JL, Kessler JL, Yu SM, Weiss JA: Collagen denaturation is initiated upon tissue yield in both positional and energy-storing tendons. Acta biomaterialia, 2020, PMCID.
  12. ↑ Lin AH, Zitnay JL, Li Y, Yu SM, Weiss JA: Microplate assay for denatured collagen using collagen hybridizing peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(2): 431-438, 2019, PMCID: PMC6576259.
  13. ↑ Zitnay JL, Weiss JA: Load transfer, damage, and failure in ligaments and tendons. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(12): 3093-3104, 2018, PMCID: PMC6454883.
  14. ↑ Weiss JA, Maker BN, Govindjee S: Finite element implementation of incompressible, transversely isotropic hyperelasticity. Comput Meth Appl Mech Eng, 135: 107-128, 1996, PMCID.
  15. ↑ Weiss JA, Gardiner JC: Computational modeling of ligament mechanics. Critical reviews in biomedical engineering, 29(3): 303-371, 2001, PMCID.
  16. ↑ Weiss JA, Gardiner JC, Ellis BJ, Lujan TJ, Phatak NS: Three-dimensional finite element modeling of ligaments: technical aspects. Medical engineering & physics, 27(10): 845-861, 2005, PMCID.
  17. ↑ Maas SA, Ellis BJ, Ateshian GA, Weiss JA: FEBio: finite elements for biomechanics. Journal of biomechanical engineering, 134(1): 011005, 2012, PMCID: 3705975.
  18. ↑ Maas SA, Ateshian GA, Weiss JA: FEBio: History and Advances. Annual review of biomedical engineering, 19: 279-299, 2017, PMCID: PMC6141040.
  19. ↑ "FEBio - Software Suite" . Retrieved 29 April 2021.
  20. ↑ Anderson AE, Ellis BJ, Maas SA, Peters CL, Weiss JA: Validation of finite element predictions of cartilage contact pressure in the human hip joint. Journal of biomechanical engineering, 130(5): 051008, 2008, PMCID: PMC2840996.
  21. ↑ Anderson AE, Peters CL, Tuttle BD, Weiss JA: Subject-specific finite element model of the pelvis: development, validation and sensitivity studies. Journal of biomechanical engineering, 127(3): 364-373, 2005, PMCID.
  22. ↑ Henak CR, Abraham CL, Anderson AE, Maas SA, Ellis BJ, Peters CL, Weiss JA: Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. Osteoarthritis and cartilage, 22(2): 210-217, 2014, PMCID: PMC3946188.
  23. ↑ Henak CR, Carruth ED, Anderson AE, Harris MD, Ellis BJ, Peters CL, Weiss JA: Finite element predictions of cartilage contact mechanics in hips with retroverted acetabula.Osteoarthritis and cartilage, 21(10): 1522-1529, 2013, PMCID: PMC3779536.
  24. ↑ Knight SJ, Abraham CL, Peters CL, Weiss JA, Anderson AE: Changes in chondrolabral mechanics, coverage, and congruency following peri-acetabular osteotomy for treatment of acetabular retroversion: A patient-specific finite element study. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 35(11): 2567-2576, 2017, PMCID:PMC5623608.
  25. ↑ Chang CC, Krishnan L, Nunes SS, Church KH, Edgar LT, Boland ED, Weiss JA, Williams SK, Hoying JB: Determinants of microvascular network topologies in implanted neovasculatures. Arteriosclerosis, thrombosis, and vascular biology, 32(1): 5-14, 2012, PMCID:PMC3256738.
  26. ↑ Krishnan L, Hoying JB, Nguyen H, Song H, Weiss JA: Interaction of angiogenic microvessels with the extracellular matrix. Am.J.Physiol Heart Circ.Physiol, 293(6): H3650-H3658, 2007, PMCID.
  27. ↑ Krishnan L, Underwood CJ, Maas S, Ellis BJ, Kode TC, Hoying JB, Weiss JA: Effect of mechanical boundary conditions on orientation of angiogenic microvessels. Cardiovascular research, 78(2): 324-332, 2008, PMCID.
  28. ↑ Underwood CJ, Edgar LT, Hoying JB, Weiss JA: Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis. American journal of physiology. Heart and circulatory physiology, 307(2): H152-164, 2014, PMCID: PMC4101638.
  29. ↑ Edgar LT, Hoying JB, Weiss JA: In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density. Annals of biomedical engineering, 43(7): 1531-1542, 2015, PMCID: PMC4629919.
  30. ↑ Edgar LT, Maas SA, Guilkey JE, Weiss JA: A coupled model of neovessel growth and matrix mechanics describes and predicts angiogenesis in vitro. Biomechanics and modeling in mechanobiology, 14(4): 767-782, 2015, PMCID: PMC4447608.
  31. ↑ Edgar LT, Sibole SC, Underwood CJ, Guilkey JE, Weiss JA: A computational model of in vitro angiogenesis based on extracellular matrix fibre orientation. Comput Methods Biomech Biomed Engin, 16(7): 790-801, 2013, PMCID: PMC3459304.
  32. ↑ "AngioFE - Musculoskeletal Research Laboratories" . The University of Utah. Retrieved 29 April 2021.
  33. ↑ "Jeffrey A. Weiss, Ph.D. - 2021 Distinguished Research Awards Recipients" . The University of Utah. Retrieved 29 April 2021.
  34. ↑ "ASME Fellows" . American Society of Mechanical Engineers. Retrieved 29 April 2021.
  35. ↑ ”Van C. Mow Medal - ASME" . American Society of Mechanical Engineers. Retrieved 29 April 2021.
  36. ↑ "Jeffrey A. Weiss, PH.D. - AIMBE College of Fellows" . American Institute for Medical Biological Engineering. Retrieved 29 April 2021.
  37. ↑ "ASME Newsmakers - Jeffrey A. Weiss, Ph.D." . American Society of Mechanical Engineers. Retrieved 29 April 2021.
  38. ↑ "NSF Career Award Abstract" . National Science Foundation. Retrieved 29 April 2021.

External links[edit]

Selected bibliography[edit]

  • Henninger HB, Maas SA, Underwood CJ, Whitaker RT, Weiss JA: Spatial distribution and orientation of dermatan sulfate in human medial collateral ligament. Journal of structural biology, 158(1): 33-45, 2007, PMCID: PMC2814165.
  • Ruehle MA, Krishnan L, LaBelle SA, Willett NJ, Weiss JA, Guldberg RE: Decorincontaining collagen hydrogels as dimensionally stable scaffolds to study the effects of compressive mechanical loading on angiogenesis. MRS communications, 7(3): 466-471, 2017, PMCID: PMC5810960.
  • Henninger HB, Ellis BJ, Scott SA, Weiss JA: Contributions of elastic fibers, collagen, and extracellular matrix to the multiaxial mechanics of ligament. Journal of the mechanical behavior of biomedical materials, 99: 118-126, 2019, PMCID: PMC7474469.
  • Zitnay JL, Jung GS, Lin AH, Qin Z, Li Y, Yu SM, Buehler MJ, Weiss JA: Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues. Science advances, 6(35): eaba2795, 2020, PMCID: PMC7455178.
  • Anderson AE, Ellis BJ, Maas SA, Weiss JA: Effects of idealized joint geometry on finite element predictions of cartilage contact stresses in the hip. Journal of biomechanics, 43(7): 1351-1357, 2010, PMCID: PMC2857573.
  • Anderson AE, Ellis BJ, Peters CL, Weiss JA: Cartilage thickness: factors influencing multidetector CT measurements in a phantom study. Radiology, 246(1): 133-141, 2008, PMCID: PMC2881220.
  • Henak CR, Kapron AL, Anderson AE, Ellis BJ, Maas SA, Weiss JA: Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies. Biomechanics and modeling in mechanobiology, 13(2): 387-400, 2014, PMCID: PMC3859708.
  • Harris MD, Anderson AE, Henak CR, Ellis BJ, Peters CL, Weiss JA: Finite element prediction of cartilage contact stresses in normal human hips. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, 30(7): 1133-1139, 2012, PMCID: PMC3348968.
  • Henak CR, Ellis BJ, Harris MD, Anderson AE, Peters CL, Weiss JA: Role of the acetabular labrum in load support across the hip joint. Journal of biomechanics, 44(12): 2201-2206, 2011, PMCID: PMC3225073.
  • Hoying JB, Utzinger U, Weiss JA: Formation of microvascular networks: role of stromal interactions directing angiogenic growth. Microcirculation (New York, N.Y. : 1994), 21(4): 278-289, 2014, PMCID: PMC4032604.
  • Utzinger U, Baggett B, Weiss JA, Hoying JB, Edgar LT: Large-scale time series microscopy of neovessel growth during angiogenesis. Angiogenesis, 18(3): 219-232, 2015, PMCID: PMC4782613.
  • Edgar LT, Hoying JB, Utzinger U, Underwood CJ, Krishnan L, Baggett BK, Maas SA, Guilkey JE, Weiss JA: Mechanical interaction of angiogenic microvessels with the extracellular matrix. Journal of biomechanical engineering, 136(2): 021001, 2014, PMCID:PMC4023669.
  • Edgar LT, Underwood CJ, Guilkey JE, Hoying JB, Weiss JA: Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis. PloS one, 9(1): e85178, 2014, PMCID: PMC3898992 Associates, but his contributions to this research and manuscript were made while he was a postdoctoral scientist in my laboratory at the University of Utah. There are no competing interests with his current employer and this research.


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