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John Simard

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John Simard
BornJohn Simard
1961 (age 64–65)
Montreal, Quebec
🎓 Alma materUniversity of Saskatchewan
University of Toronto
💼 Occupation

John Simard (born 1961) is a Canadian-born biotechnology entrepreneur and the founder and CEO of XBiotech.[1][2]

Early life and education

John Simard was born in 1961 in Montreal, Quebec, Canada.[1] He earned a biochemistry degree from the University of Saskatchewan in 1992, then pursued graduate studies in immunology at the University of Toronto's Department of Medical Biophysics.[3][4]

In 1994, Simard left his graduate program to work with Tak W. Mak at the Amgen Research Institute, where he co-authored a textbook on immunology with Mak.[4] He also co-authored a manuscript with Nobel Laureate Rolf Zinkernagel, focusing on the biology of cytotoxic T lymphocytes (CTL).[4]

Career

Simard began his career in biotechnology by establishing CTL Immunotherapies in 1997, a developer of therapeutic vaccines.[1][5] Later, he also founded AlleCure Corp. in Valencia, California, which developed allergy treatments and immune modulating therapies.[6][5] His first two companies were eventually merged with MannKind Corporation. Simard remained in MannKind as president of its immunology division and a member of the board of directors.[1][7][8]

In 2005, Simard founded XBiotech, which specializes in the research and development of human-derived antibody therapeutics for cancer, inflammatory and infectious diseases.[1][3]

Research

Simard has pioneered immunotherapies targeting interleukin 1-alpha, including a neutralizing antibody that was sold for a total of $1.35 billion in cash and potential milestone payments.[9][4] He holds over 300 issued and pending patents in areas such as cancer antigen identification, immunotherapies for cancer and infectious diseases, and techniques for identifying and cloning human antibodies.[4]

References

  1. 1.0 1.1 1.2 1.3 1.4 https://www.bizjournals.com/austin/print-edition/2014/10/17/meet-john-simard-ceo-of-xbiotech.html
  2. https://www.bizjournals.com/austin/news/2020/06/11/austins-top-paid-ceos.html
  3. 3.0 3.1 "John Simard, Xbiotech USA Inc: Profile and Biography". Bloomberg.com.
  4. 4.0 4.1 4.2 4.3 4.4 "John Simard". XBiotech.
  5. 5.0 5.1 Rockwell, Lilly. "How Austin's XBiotech aims to revolutionize drug discovery". Austin American-Statesman.
  6. Institute, ERI Economic Research. "John Simard Salary Information 2022". ERI Economic Research Institute.
  7. "BIOTECH---Mann Slates Biotech IPO by Year End". 13 May 2001.
  8. https://www.bizjournals.com/austin/print-edition/2011/01/28/xbiotech-has-huge-plans.html
  9. https://www.bizjournals.com/austin/news/2020/02/10/1-35b-deal-offers-vindication-runway-for-austin.html


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