Lymphocyte expansion molecule
Lymphocyte expansion molecule (LEXM) is a protein discovered in 2015, found to be involved in immune responses (in mice) to some cancers and viruses.[1][2] The protein was initially found to be responsible for an increased production of T cells in mice. The original paper has since been retracted upon recommendation of Imperial College’s investigators due to concerns about duplication of data.[3] The protein may be relevant to humans and could be a target for drug discovery.[4][5]
Scientists at Imperial College are developing a gene therapy based on this protein.[1]
References
- ↑ 1.0 1.1 Knapton S (16 April 2015). "Scientists find key to 'turbo-charging' immune system to kill all cancers". telegraph.co.uk. The Telegraph. Retrieved 8 September 2017.
- ↑ Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, Crouse J, Choi O, Heathcote D, Lovo E, Mauro C, Abdi R, Oxenius A, Rutschmann S, Ashton-Rickardt PG (May 2015). "RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration". Science. 348 (6238): 995–1001. doi:10.1126/science.aaa7516. hdl:10044/1/34339. PMID 25883318. (Retracted, see doi:10.1126/science.aal5242, PMID 27980177, Retraction Watch)
- ↑ Retraction. 2016
- ↑ Previously Unknown Protein Boosts Immunity to Cancer and Viruses. 2015
- ↑ 'Game-changing' new way to fight cancer discovered
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