Micro-arrays for mass spectrometry

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Micro-arrays for mass spectrometry (MAMS); introduced by the group of Renato Zenobi in 2010, is an analytical platform for high-throughput analysis of single cells and other low-volume samples by mass spectrometry.[1][2]

Principle[edit]

The mechanism of operation involves unsupervised separating or aliquoting of cell suspensions, or other liquid samples, into discrete recipient sites. The aliquoting effect is achieved due to the differences in wettability of the recipient sites and the surrounding area.[1]

Applications[edit]

MAMS are used in single-cell analysis; in particular, single-cell metabolomics.[1][3][4][5][6] Other applications include: interfacing microfluidics,[7] chromatography,[8] and quantitative mass spectrometry.[9]

References[edit]

  1. 1.0 1.1 1.2 Urban, Pawel L.; Jefimovs, Konstantins; Amantonico, Andrea; Fagerer, Stephan R.; Schmid, Thomas; Mädler, Stefanie; Puigmarti-Luis, Josep; Goedecke, Nils; Zenobi, Renato (2010). "Urban P.L., Jefimovs K., Amantonico A., Fagerer S.R., Schmid T., Mädler S., Puigmarti-Luis J., Goedecke N., Zenobi R. 2010, High-density micro-arrays for mass spectrometry. Lab on a Chip 10:3206-3209". Lab on a Chip. 10 (23): 3206–9. doi:10.1039/C0LC00211A. PMID 20938499.
  2. "Patent publication No. WO2011144743 (A1) ― 2011-11-24 - Espacenet". Retrieved 3 December 2016.
  3. Urban, Pawel L.; Schmidt, A. Mareike; Fagerer, Stephan R.; Amantonico, Andrea; Ibañez, Alfredo; Jefimovs, Konstantins; Heinemann, Matthias; Zenobi, Renato (2011). "Urban P.L., Schmidt A.M., Fagerer S.R., Amantonico A., Ibañez A., Jefimovs K., Heinemann M., Zenobi R. 2011, Carbon-13 labelling strategy for studying the ATP metabolism in individual yeast cells by micro-arrays for mass spectrometry. Molecular BioSystems 7:2837-2840" (PDF). Molecular BioSystems. 7 (10): 2837. doi:10.1039/C1MB05248A. PMID 21850345.
  4. Ibanez, A. J.; Fagerer, S. R.; Schmidt, A. M.; Urban, P. L.; Jefimovs, K.; Geiger, P.; Dechant, R.; Heinemann, M.; Zenobi, R. (2013). "Ibañez A.J., Fagerer S.R., Schmidt A.M., Urban P.L., Jefimovs K., Geiger P., Dechant R.C., Heinemann M., Zenobi R. 2013, Mass spectrometry-based metabolomics of single yeast cells. Proceedings of the National Academy of Sciences (USA) 110:8790-8794". Proceedings of the National Academy of Sciences. 110 (22): 8790–8794. doi:10.1073/pnas.1209302110. PMC 3670324. PMID 23671112.
  5. Fagerer, Stephan R.; Schmid, Thomas; Ibáñez, Alfredo J.; Pabst, Martin; Steinhoff, Robert; Jefimovs, Konstantins; Urban, Pawel L.; Zenobi, Renato (2013). "Analysis of single algal cells by combining mass spectrometry with Raman and fluorescence mapping". The Analyst. 138 (22): 6732. doi:10.1039/C3AN01135F. PMID 24027777.
  6. Zenobi, R. (2013). "Single-Cell Metabolomics: Analytical and Biological Perspectives". Science. 342 (6163): 1243259. doi:10.1126/science.1243259. PMID 24311695. Retrieved 11 January 2014.
  7. Küster, Simon K.; Fagerer, Stephan R.; Verboket, Pascal E.; Eyer, Klaus; Jefimovs, Konstantins; Zenobi, Renato; Dittrich, Petra S. (2013). "Interfacing Droplet Microfluidics with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry: Label-Free Content Analysis of Single Droplets". Analytical Chemistry. 85 (3): 1285–1289. doi:10.1021/ac3033189.
  8. Küster, Simon K.; Pabst, Martin; Jefimovs, Konstantins; Zenobi, Renato; Dittrich, Petra S. (2014). "High-Resolution Droplet-Based Fractionation of Nano-LC Separations onto Microarrays for MALDI-MS Analysis". Analytical Chemistry. 86 (10): 4848–4855. doi:10.1021/ac4041982.
  9. Pabst, Martin; Fagerer, Stephan R.; Köhling, Rudolf; Küster, Simon K.; Steinhoff, Robert; Badertscher, Martin; Wahl, Fabian; Dittrich, Petra S.; Jefimovs, Konstantins; Zenobi, Renato (2013). "Self-Aliquoting Microarray Plates for Accurate Quantitative Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry". Analytical Chemistry. 85 (20): 9771–9776. doi:10.1021/ac4021775.


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