Myron Evans II
| Myron Evans II | |
|---|---|
| File:Myron evans II.jpgMyron evans II.jpg | |
| Born | Kentucky, Fort Campbell |
| 🎓 Alma mater | Florida International University (BS) Duke University (PhD) |
| 💼 Occupation | |
| 🌐 Website | https://www.seattlechildrens.org/directory/myron-evans/ |
Myron Evans II is a Principal Investigator at Ben Towne Center for Childhood Cancer Research and Assistant Professor at the University of Washington School of Medicine[1] in the Pediatric Department. His research consists of pediatric brain tumor development, with a focus on medulloblastoma, diffuse midline glioma, and atypical teratoid/rhabdoid tumors. Other projects include postnatal tumor development of the cerebellum and identifying new brain tumor target treatments with fewer side effects such as CAR T-Cell Therapy.[2]
Early life
Myron Evans II was born in Fort Campbell, Kentucky. At age 4, he moved to St. Augustine, Florida. He developed an early interest in biology and medicine as his mother worked as a nurse.[1]
Education
Myron Evans II attended Florida International University in 2006, earning his Bachelor of Science with honors in Developmental Biology. As an undergraduate, he studied the role of signaling pathways in melanocytes and melanomagenesis in the lab of Lidia Kos. He also worked in Mark von Zastrow's lab which advised and inspired him to pursue research instead of becoming a physician.[3]
In 2010, he attended Duke University for his Doctor of Philosophy (Ph.D.) in Pathology/Experimental Pathology. Evans was a graduate student of Gayathri Devi studying therapeutics for inflammatory breast cancer, mechanisms of oxidative stress, proliferative signaling and therapeutic resistance in inflammatory breast cancer (IBC). Evans graduated from Duke University in 2016 and soon after joined St. Jude Children's Research Hospital as a Postdoctoral Research Fellow.[3]
Research
At St. Jude Children's Research Hospital, he studied epigenetics in early human and mouse neural development in the lab of Jamy Peng. He also worked in the lab of Mark Hatley which researched functional genomics and single cell technologies to better understand tumorigenesis and progression of the soft tissue sarcoma and rhabdomyosarcoma in children.[4]
In 2021, Evans became a full-time Assistant Professor at University of Washington School of Medicine and Principal Investigator (PI) at Seattle Children's Research Institute Ben Towne Center for Childhood Cancer Department. He is also an affiliate assistant member at Fred Hutchinson Cancer Research Center in the Human Biology Division.[1]
His current research lab studies mammalian postnatal development of the cerebellum, specifically mapping out how various genes, cells and molecules interact to form the brain. One gene of interest is the RNA/DNA binding protein YBX1 with a specific focus on how it controls stem cell proliferation and differentiation.[5] In conjunction, his lab also focuses on developing new therapies for medulloblastoma,[6] specifically the protein TP53-mutant SHH.[5]
In collaboration with the Vitanza Lab, his team is studying how targeting DNA modifiers can enhance response to chimeric antigen receptor (CAR) T-cell therapy. More specifically, his lab is working to find better methods to enhance the expression of HER2—increasing HER2 expression in tumors is believed to enhance the efficacy of immunotherapy.[5] As of May 2022, there are ongoing trials that utilize CAR T-cell therapy to target an antigen called HER2 on the surface of pediatric brain tumors. These therapies are more targeted, often having less severe side effects when compared to chemotherapy and radiotherapy.[7][8]
Evan's lab uses techniques including CRISPR, single cell sequencing, functional genomics, and spatial transcriptomics to understand the genetic and epigenetic control of brain development.[9]
Teaching and mentorship
Evans was a visiting Assistant Professor at Rhodes College where he taught upper-level Genetics and Genetics Lab (BIOL 304). Evans was a member of the programming and development committee for Science Scholars of Tomorrow,[10] a program that gives local high school students a glimpse of the research conducted at St. Jude Children's Research Hospital. He's involved in the Summer Scholars Program at Seattle Children's Research Institute.[11]
Honors, recognition and awards
| Year | Award Title |
|---|---|
| 2006 | Top Undergraduate Award in Cell Biological Sciences at Annual Biomedical Research Conference for Minority Students (ABRCMS) |
| 2009 | AMGEN Scholar at UCSF |
| 2010 | Research on breast cancer metastasis was awarded Defense Breakthrough |
| 2016 | NIH NRSA F32 Individual Postdoctoral Fellowship |
| 2018 | St. Jude/Rhodes College Teaching Fellowship |
Selected publications
- Evans, Myron K.; Tovmasyan, Artak; Batinic-Haberle, Ines; Devi, Gayathri R. (March 2014). "Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death". Free Radical Biology and Medicine. 68: 302–314. doi:10.1016/j.freeradbiomed.2013.11.031. PMC 4404036. PMID 24334253. (2014)[12]
- Allensworth, Jennifer L.; Evans, Myron K.; Bertucci, François; Aldrich, Amy J.; Festa, Richard A.; Finetti, Pascal; Ueno, Naoto T.; Safi, Rachid; McDonnell, Donald P.; Thiele, Dennis J.; Van Laere, Steven (June 2015). "Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer". Molecular Oncology. 9 (6): 1155–1168. doi:10.1016/j.molonc.2015.02.007.(2015)[13]
- Evans, M K; Sauer, S J; Nath, S; Robinson, T J; Morse, M A; Devi, G R (January 2016). "X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity". Cell Death & Disease. 7 (1): e2073–e2073. doi:10.1038/cddis.2015.412. ISSN2041-4889. PMC4816185. PMID26821068.(2016)[14]
- Evans, Myron K.; Brown, Michael C.; Geradts, Joseph; Bao, Xuhui; Robinson, Timothy J.; Jolly, Mohit Kumar; Vermeulen, Peter B.; Palmer, Gregory M.; Gromeier, Matthias; Levine, Herbert; Morse, Michael A. (2018-04-01). "XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype". Cancer Research. 78 (7): 1726–1738. doi:10.1158/0008-5472.CAN-17-1667. ISSN1538-7445. PMC 7724565. PMID29351901.(April 1, 2018)[15]
- Yang, Xiaoyang; Xu, Beisi; Mulvey, Brett; Evans, Myron; Jordan, Samuel; Wang, Yong-Dong; Pagala, Vishwajeeth; Peng, Junmin; Fan, Yiping; Patel, Arishna; Peng, Jamy C. (March 2019). "Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1". Nature Neuroscience. 22 (3): 362–373. doi:10.1038/s41593-018-0328-5. ISSN 1546-1726. PMC 6511450. PMID 30718900. (Mar 2019)[4]
- Evans, Myron K.; Matsui, Yurika; Xu, Beisi; Willis, Catherine; Loome, Jennifer; Milburn, Luis; Fan, Yiping; Pagala, Vishwajeeth; Peng, Jamy C. (2020-08-13). "Ybx1 fine-tunes PRC2 activities to control embryonic brain development". Nature Communications. 11 (1): 4060. doi:10.1038/s41467-020-17878-y. ISSN 2041-1723. PMC 8361998. PMID 32788728.(Aug 13, 2020)[16]
References
- ↑ 1.0 1.1 1.2 "Myron Evans II, PhD". Seattle Children’s Hospital. Seattle Children's Research Institute. Retrieved 2022-04-25.
- ↑ "Myron Evans II Lab". Seattle Children’s Hospital. Retrieved 2022-04-25.
- ↑ 3.0 3.1 "evansmk". www.peds.uw.edu. Retrieved 2022-05-22.
- ↑ 4.0 4.1 Yang, Xiaoyang; Xu, Beisi; Mulvey, Brett; Evans, Myron; Jordan, Samuel; Wang, Yong-Dong; Pagala, Vishwajeeth; Peng, Junmin; Fan, Yiping; Patel, Arishna; Peng, Jamy C. (March 2019). "Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1". Nature Neuroscience. 22 (3): 362–373. doi:10.1038/s41593-018-0328-5. ISSN 1546-1726. PMC 6511450 Check
|pmc=value (help). PMID 30718900. - ↑ 5.0 5.1 5.2 "Myron Evans II Lab". Seattle Children’s Hospital. Retrieved 2022-04-30.
- ↑ "Advancing New Treatment Options". Seattle Children’s Hospital. Retrieved 2022-05-10.
- ↑ "T-Cell Immunotherapy Overview". Seattle Children’s Hospital. Retrieved 2022-05-10.
- ↑ "Harnessing the Power of the Immune System". Seattle Children’s Hospital. Retrieved 2022-05-10.
- ↑ "Ben Towne Center for Childhood Cancer Research - Seattle Children's". Seattle Children’s Hospital. Retrieved 2022-04-30.
- ↑ "Science Scholars of Tomorrow Symposium". www.stjude.org. Retrieved 2022-05-10.
- ↑ "Underrepresented Minorities in Research Summer Internship Program". Seattle Children’s Hospital. Retrieved 2022-05-22.
- ↑ Evans, Myron K.; Tovmasyan, Artak; Batinic-Haberle, Ines; Devi, Gayathri R. (March 2014). "Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death". Free Radical Biology and Medicine. 68: 302–314. doi:10.1016/j.freeradbiomed.2013.11.031. PMC 4404036. PMID 24334253.
- ↑ Allensworth, Jennifer L.; Evans, Myron K.; Bertucci, François; Aldrich, Amy J.; Festa, Richard A.; Finetti, Pascal; Ueno, Naoto T.; Safi, Rachid; McDonnell, Donald P.; Thiele, Dennis J.; Van Laere, Steven (June 2015). "Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer". Molecular Oncology. 9 (6): 1155–1168. doi:10.1016/j.molonc.2015.02.007.
- ↑ Evans, M K; Sauer, S J; Nath, S; Robinson, T J; Morse, M A; Devi, G R (January 2016). "X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity". Cell Death & Disease. 7 (1): e2073–e2073. doi:10.1038/cddis.2015.412. ISSN 2041-4889. PMC 4816185. PMID 26821068.
- ↑ Evans, Myron K.; Brown, Michael C.; Geradts, Joseph; Bao, Xuhui; Robinson, Timothy J.; Jolly, Mohit Kumar; Vermeulen, Peter B.; Palmer, Gregory M.; Gromeier, Matthias; Levine, Herbert; Morse, Michael A. (2018-04-01). "XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype". Cancer Research. 78 (7): 1726–1738. doi:10.1158/0008-5472.CAN-17-1667. ISSN 1538-7445. PMC 7724565 Check
|pmc=value (help). PMID 29351901. - ↑ Evans, Myron K.; Matsui, Yurika; Xu, Beisi; Willis, Catherine; Loome, Jennifer; Milburn, Luis; Fan, Yiping; Pagala, Vishwajeeth; Peng, Jamy C. (2020-08-13). "Ybx1 fine-tunes PRC2 activities to control embryonic brain development". Nature Communications. 11 (1): 4060. doi:10.1038/s41467-020-17878-y. ISSN 2041-1723. PMC 8361998 Check
|pmc=value (help). PMID 32788728 Check|pmid=value (help).
External links
- Myron Evans II publications indexed by Google Scholar
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