Pascale S. Guiton
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| Pascale S. Guiton | |
|---|---|
| Born | |
| 🏫 Education | Georgia State University (BS Biological Sciences, 2005) Washington University in St. Louis (Ph.D. Biological Sciences and Medicine, 2012) |
| 💼 Occupation | Assistant Professor and Researcher at California State University, East Bay |
| 🌐 Website | https://guitonlab.com |
Pascale Guiton is an assistant professor and researcher in the Department of Biological Sciences at California State University, East Bay.[1] Her main fields of study are microbiology and parasitology, with much of her research focused on the parasite Toxoplasma gondii.
Early life and education[edit]
Pascale Guiton was born in Dechy, France and grew up Abidjan, Côte d'Ivoire. She attended high school at Lycée Classique d'Abidjan, graduating in 2001. After high school, she moved to the U.S. and applied to Georgia State University for her undergraduate degree. She was originally rejected, due to the harsher grading system in French schools compared to American schools. However, after appealing this decision, she was accepted and went on to receive a B.S. in Biological Sciences in 2005, graduating summa cum laude.[1] She also received the William S. Kell Presidential Award for Academic Excellence. After that, she earned her Ph.D. in Biological Sciences and Medicine at Washington University in St. Louis in 2012, where she was part of the Edward A. Bouchet Graduate Honor Society.[1][2] She completed a Postdoctoral Fellowship at the Stanford University School of Medicine from 2012 to 2017, where she worked in the lab of John C. Boothroyd.[1]
Career and research[edit]
Guiton currently works as an Assistant Professor of Biological Sciences at California State University, East Bay, where she teaches multiple undergraduate and graduate courses in microbiology, immunology, and parasitology.[1] She also teaches courses focusing on women's contributions to the biological sciences.[1] She received the Outstanding Mentor of Students Award for the 2020–2021 school year.[3] Guiton is also the Principal Investigator of a research lab, which studies Toxoplasma gondii, one of the most commonly found parasites in humans.[1] Much of her research on Toxoplamsa gondii aims to find new differentiation and virulence factors, by studying host-pathogen interactions at the molecular level.[1][4] Her research has been published in several peer-reviewed journals, including Infection and Immunity, mBio, Antimicrobial Agents and Chemotherapy, and PLOS One. Her publications "Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infection" and "Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections" were both selected as articles of significant interest in the journal issues in which they were published.[5][6]
Advocacy and social justice[edit]
Guiton has written extensively about race, gender, and socioeconomic status in STEM fields, as well as her experiences as a Black woman working in research and education. In her paper "No More Excuses - Addressing Race, Racism, and Socioeconomic Issues in the Science Classroom and Laboratory," Guiton discusses the importance of integrating social issues into science curriculum.[7] She argues that educators have a responsibility to "engage students in more in-depth discussions around science-related issues, social justice, and basic human rights".[7] Guiton believes that educators and scientists should not shy away from potentially controversial topics, as they are necessary for students to recognize the biases and cultural contexts that inform research and science curriculum.[7] Guiton is also one of the authors of "Atlas of Black Scholarship for Inclusive and Racially Diverse STEM Curricula," a text that highlights the contributions of 120 Black scientists and physicians to different STEM fields.[8] The aim of this document is to provide educators with information on the discoveries and achievements of Black scholars, which can then be integrated into in their course content.[8] Guiton is also a co-founder of The Alliance for the Black Community (ABC) at CSU East Bay. ABC is a group of faculty, staff, and students who work to improve the experiences of Black students and faculty members in higher education.[9] Through her work with ABC, Guiton has co-authored "Designing an Anti-Racist Syllabus" and "Anti-Racist Educator's Starting Guides."[9][10] Guiton, along with other faculty members at CSU East Bay, previously spoke out against an economics professor for teaching a theory that race influences intelligence.[11][12][13] During a meeting of the CSU East Bay Board of Trustees, Guiton objected to this teaching by saying that this professor "asserts in his work that people of sub-Saharan African descent, people like me and many of our students, have significantly lower IQs than any other ethnicity."[12]
Selected publications[edit]
- Sharma J, Rodriguez P, Roy P, Guiton PS. Transcriptional ups and downs: patterns of gene expression in the life cycle of Toxoplasma gondii. Microbes Infect. 2020.[14]
- Guiton PS, Sagawa J, Fritz H, JC Boothroyd. An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells. PLoS One. 2017 Mar 31;12(3):e0173018.[15]
- Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ. Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infect. Immun. 2013 81(1):329-39.[6]
- Frank KL, Guiton PS, Barnes AM, Manias DA, Chuang-Smith ON, Kohler PL, Spaulding AR, Hultgren SJ, Schlievert, PM, Dunny GM. AhrC and Eep are biofilm infection-associated virulence factors in Enterococcus faecalis. Infect. Immun. 2013 81(5):1696-708.[16]
- Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. Combinatorial small-molecular therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrob. Agents Chemother. 2012 56(9):4738-45.[17]
- Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ. The metal ion-dependent adhesion site motif of EbpA pilin mediates pilus function in catheter-associated urinary tract infection. Mbio. 2012 3(4):e00177-12.[18]
- Guiton PS, Hung CS, Hancock L., Caparon MG, Hultgren SJ. Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infection. Infect. Immun. 2010 78(10):4166-4175.[5]
- Guiton PS, Hung CS, Kline KA, Roth R, Kau AL, Hayes E, Heuser J, Dodson KW, Caparon MG, Hultgren SJ. Contribution of autolysin and sortase A during Enterococcus faecalis DNA-dependent biofilm development. Infect. Immun. 2009 77(9):3626-38.[19]
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "Pascale S. Guiton, Ph.D. Faculty Profile". www.csueastbay.edu. Retrieved 2021-04-21.
- ↑ "Two doctoral students named Bouchet Fellows | The Source | Washington University in St. Louis". The Source. 2011-04-12. Retrieved 2021-05-26.
- ↑ "Faculty and Staff Awards". www.csueastbay.edu. Retrieved 2021-05-03.
- ↑ "The #NextGreatDiscovery". news.stanford.edu. 2015-09-28. Retrieved 2021-05-26.
- ↑ 5.0 5.1 Guiton, Pascale S.; Hung, Chia S.; Hancock, Lynn E.; Caparon, Michael G.; Hultgren, Scott J. (October 2010). "Enterococcal Biofilm Formation and Virulence in an Optimized Murine Model of Foreign Body-Associated Urinary Tract Infections". Infection and Immunity. 78 (10): 4166–4175. doi:10.1128/IAI.00711-10. ISSN 0019-9567. PMC 2950371. PMID 20696830.
- ↑ 6.0 6.1 Guiton, Pascale S.; Hannan, Thomas J.; Ford, Bradley; Caparon, Michael G.; Hultgren, Scott J. (January 2013). Morrison, R. P., ed. "Enterococcus faecalis Overcomes Foreign Body-Mediated Inflammation To Establish Urinary Tract Infections". Infection and Immunity. 81 (1): 329–339. doi:10.1128/IAI.00856-12. ISSN 0019-9567. PMC 3536162. PMID 23132492.
- ↑ 7.0 7.1 7.2 Guiton, Pascale S. (2021-02-24). "mSphere of Influence: No More Excuses—Addressing Race, Racism, and Socioeconomic Issues in the Science Classroom and Laboratory". mSphere. 6 (1). doi:10.1128/mSphere.00010-21. ISSN 2379-5042. PMC 7845619 Check
|pmc=value (help). PMID 33472980 Check|pmid=value (help). - ↑ 8.0 8.1 Anandkumar, Aparna; Moline, Ariel; Guiton, Pascale (2020). "Atlas of Black Scholarship for Inclusive and Racially Diverse STEM Curricula – Volume I". Pascale Guiton. doi:10.25334/CEM2-HH58.
- ↑ 9.0 9.1 Education, CSUEB; Almeida, Ana; Geron, Kim; Guiton, Pascale; Haft, Nina; Halim, Marlin; Higby, Eve; Lee, Michael; McClain, ZáNean (2021). "Designing an Anti-Racist Syllabus". Pascale Guiton. doi:10.25334/DRZC-3P90.
- ↑ Community, CSUEB; Sumner, Nicole; Chin-Newman, Christina; Haft, Nina; Murphy, Jessika; Coskran, Shannon; Lee, Michael; Pollock, Ian; Pakpour, Nazzy; Guiton, Pascale (2020). "Anti-Racist Educator's Starting Guides". Pascale Guiton. doi:10.25334/FDKH-1X80.
- ↑ Fagone, Jason (2020-11-01). "An East Bay professor is teaching racist theories on intelligence. Students and faculty want him out". San Francisco Chronicle. Retrieved 2021-05-26.
- ↑ 12.0 12.1 "A Cal State professor published eugenics-linked papers. Now come calls for a reckoning". Los Angeles Times. 2020-10-31. Retrieved 2021-05-26.
- ↑ "Outcry Over CSUEB Professor Who Teaches Theory of Race Influencing Intelligence". NBC Bay Area. Retrieved 2021-05-26.
- ↑ Sharma, Janak; Rodriguez, Paula; Roy, Proyasha; Guiton, Pascale S. (2020-11-01). "Transcriptional ups and downs: patterns of gene expression in the life cycle of Toxoplasma gondii". Microbes and Infection. 22 (10): 525–533. doi:10.1016/j.micinf.2020.09.001. ISSN 1286-4579. PMID 32931908 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Guiton, Pascale S.; Sagawa, Janelle M.; Fritz, Heather M.; Boothroyd, John C. (2017-03-31). "An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells". PLOS ONE. 12 (3): e0173018. Bibcode:2017PLoSO..1273018G. doi:10.1371/journal.pone.0173018. ISSN 1932-6203. PMC 5376300. PMID 28362800.
- ↑ Frank, Kristi L.; Guiton, Pascale S.; Barnes, Aaron M. T.; Manias, Dawn A.; Chuang-Smith, Olivia N.; Kohler, Petra L.; Spaulding, Adam R.; Hultgren, Scott J.; Schlievert, Patrick M.; Dunny, Gary M. (May 2013). Payne, S. M., ed. "AhrC and Eep Are Biofilm Infection-Associated Virulence Factors in Enterococcus faecalis". Infection and Immunity. 81 (5): 1696–1708. doi:10.1128/IAI.01210-12. ISSN 0019-9567. PMC 3648002. PMID 23460519.
- ↑ Guiton, Pascale S.; Cusumano, Corinne K.; Kline, Kimberly A.; Dodson, Karen W.; Han, Zhenfu; Janetka, James W.; Henderson, Jeffrey P.; Caparon, Michael G.; Hultgren, Scott J. (September 2012). "Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice". Antimicrobial Agents and Chemotherapy. 56 (9): 4738–4745. doi:10.1128/AAC.00447-12. ISSN 0066-4804. PMC 3421856. PMID 22733070.
- ↑ Nielsen, Hailyn V.; Guiton, Pascale S.; Kline, Kimberly A.; Port, Gary C.; Pinkner, Jerome S.; Neiers, Fabrice; Normark, Staffan; Henriques-Normark, Birgitta; Caparon, Michael G.; Hultgren, Scott J. (2012-07-24). Collier, R. John, ed. "The Metal Ion-Dependent Adhesion Site Motif of the Enterococcus faecalis EbpA Pilin Mediates Pilus Function in Catheter-Associated Urinary Tract Infection". mBio. 3 (4): e00177–12. doi:10.1128/mBio.00177-12. ISSN 2150-7511. PMC 3419518. PMID 22829678.
- ↑ Guiton, Pascale S.; Hung, Chia S.; Kline, Kimberly A.; Roth, Robyn; Kau, Andrew L.; Hayes, Ericka; Heuser, John; Dodson, Karen W.; Caparon, Michael G.; Hultgren, Scott J. (September 2009). "Contribution of Autolysin and Sortase A during Enterococcus faecalis DNA-Dependent Biofilm Development". Infection and Immunity. 77 (9): 3626–3638. doi:10.1128/IAI.00219-09. ISSN 0019-9567. PMC 2738007. PMID 19528211.
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