Rainer H. Straub
Rainer H. Straub (born March 29, 1960 in Freiburg im Breisgau) is a German professor, university lecturer, and medical researcher.
Education and Academic Positions[edit]
He finished his medical studies at the Albert-Ludwigs-University Freiburg in 1988. He carried out his doctoral thesis on nystagmography between 1984 and 1988.[1][2] Hereafter, he made his internship at the same hospital, and later became Postdoc in the Department of Endocrinology and Diabetology at University Medical Center Freiburg.[1] In 1991, he moved to the University Hospital Regensburg to continue clinical work in Internal Medicine (director: Prof. Juergen Schoelmerich).[1] After a research fellowship at the Institute of Pharmacology of the University of Vienna, Austria, he worked on the interaction of the peripheral nervous system and the immune system.[1] In 1995, at the University Hospital Regensburg, he received his qualification as lecturer (the German Habilitation) and as consultant of Internal Medicine.[1] After further two years, in 1997, he became consultant of Rheumatology.[1][3] Since 2001, he is Professor of Experimental Medicine with a focus in Rheumatology. At the University Hospital, he heads the Laboratory of Experimental Rheumatology and Neuroendocrine Immunology. His research followed several major lines of Neuroendocrine Immunology in order to study pathophysiology of chronic systemic inflammatory diseases. The major focus was on rheumatoid arthritis but also other chronic inflammatory diseases.[1][4][5][6][7][8]
Scientific contributions[edit]
First, he focused on the neuroimmune synapse in the spleen, the site of nervous - immune crosstalk in a lymphoid organ. This site is important because the sympathetic nervous system modulates immune responses. Depending on local conditions, the neuroimmune synapse can have either proinflammatory or anti-inflammatory effects.[9][10][11][12]
Second, during these studies, he became aware of the loss of sympathetic nerve fibers and the sprouting response of sensory nerve fibers in inflamed tissue of, for example, patients with rheumatoid arthritis.[4][13] During these studies, he also recognized a new cell type, which was called tyrosine hydroxylase – positive cell that was able to produce catecholamines independent of the nervous system. [4][13] These new cells have anti-inflammatory capacities.[14]
Third, he investigated steroid hormone conversion from precursor steroid molecules to downstream steroid hormones, particularly of sex hormones and glucocorticoids in chronic systemic inflammatory diseases such as rheumatoid arthritis.[6][15][8][16][17][18][19] From these studies, it is obvious that typical proinflammatory steroid hormones are produced locally or that anti-inflammatory hormonal pathways are inhibited.
Fourth, in recent years Straub developed a new model of pathophysiology of chronic systemic inflammatory diseases that integrated Evolutionary medicine, Circadian rhythms, Energy regulation, and Volume regulation (that is handling of body water).[20][21][22][23][24][25][26][27][28]
These models also entered several books of Rainer H. Straub.[26][28]
Rainer H. Straub was spokesman of the German Endocrine Brain Immune Network (GEBIN)[29], of the interdisciplinary Study Group Neuroendocrine Immunology of the German Society of Immunology (DGFI)[30], of the Neuroendocrine Immune Study Group of the American College of Rheumatology, and of the Research Unit of the German Research Foundation (DFG) at the University Hospital Regensburg. [31]
Between 2009 and 2010 he was President of the scientific PsychoNeuroImmunology Research Society (PNIRS) (Journal: Brain Behavior & Immunity).[32] He was a lecturer on the 44th Nobel Conference at the Karolinska Institute in Stockholm in 2003, in 2013 he gave the Philip-Hench-Lecture of the American College of Rheumatology and in 2015 the Norman-Cousins Lecture of the PsychoNeuroImmunology Research Society (PNIRS).[1][25][33]
He is/was member of several Editorial Boards such as, for example, Arthritis & Rheumatism, Rheumatology, “Evolution, Medicine, and Public Health”, Journal of Endocrinology, Neuroimmunomodulation, Brain Behavior & Immunity, and Clinical and Experimental Rheumatology.
He supervised the thesis of more than 80 fellows in Medicine, Biology, Pharmacology, Chemistry, Ecotrophology and others.[1]
He was supported by funds of the Deutsche Forschungsgemeinschaft[34], the German Academic Exchange Service (DAAD), the Federal Ministry of Education and Research, the Volkswagen Foundation, and the Federal State of Bavaria.
Publications[edit]
He gave more than 250 invited scientific lectures. He presented more than 350 scientific articles [35][36] and book chapters[37][38][39] Furthermore, he published several textbooks in German and English:
- The Neuroendocrine Immune Network in Ageing. Elsevier, 2004, ISBN 978-0444516176 Search this book on
.. - Vernetztes Denken in der biomedizinischen Forschung. Psycho-Neuro-Endokrino-Immunologie. Vandenhoeck & Ruprecht, 2005, ISBN 978-3-525-45050-5 Search this book on ..
- Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 1:Physiologische Grundlagen Vandenhoeck & Ruprecht, 2006, ISBN 978-3-525-45051-2 Search this book on .
- Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 2:Spezielle Pathophysiologie Vandenhoeck & Ruprecht, 2007, ISBN 978-3-525-45052-9 Search this book on .
- The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae. Elsevier, 2015, ISBN 978-0128033210 Search this book on .
- Altern, Muedigkeit und Entzuendungen verstehen: Wenn Immunsystem und Gehirn um die Energie im Koerper ringen. Springer, 2018, ISBN 978-3662557860 Search this book on .
External Links[edit]
Rheumanet Regensburg – Straub research unit FOR696 of the Deutsche Forschungsgemeinschaft (DFG) at the University Regensburg
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Rheumanet Regensburg - Straub. Website of Rainer H. Straub at University Regensburg. Retrieved on 2018-01-30.
- ↑ Straub RH, Thoden U. (1992). A modified method of electronystagmography for recording eye movement during the galvanic vestibular test Journal for Oto-Rhino-Laryngology and its related specialities 54(1):21-4. Abstract in PubMed. Retrieved on 2018-01-30.
- ↑ University Hospital Regensburg - Rheumatology research Website of the University Hospital Regensburg – Rheumatology. Retrieved on 2018-01-30.
- ↑ 4.0 4.1 4.2 Pongratz G, Straub RH. (2013). Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Review article in Nature Reviews Rheumatology, 9:117–126. Abstract on PubMed. Retrieved on 2018-01-30.
- ↑ Pongratz G, Straub RH. (2014). The sympathetic nervous response in inflammation Review article in Arthritis Research & Therapy, 16:504. Full text at PubMed. Retrieved on 2018-01-30.
- ↑ 6.0 6.1 Straub RH et al. (2013). Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases—The 10-year update Review article in Seminars in Arthritis and Rheumatism, 43(3):392-404. Abstract retrieved on 2018-01-30.
- ↑ Straub RH. (2014). Interaction of the endocrine system with inflammation: a function of energy and volume regulation Review article in Arthritis Research & Therapy, 16:203. Full text retrieved on 2018-01-30.
- ↑ 8.0 8.1 Straub RH, Cutulo M. (2016). Glucocorticoids and chronic inflammation Review article in Rheumatology, 55:ii6-ii14. Full text retrieved on 2018-01-30.
- ↑ Straub RH. (2004). Complexity of the bi-directional neuroimmune junction in the spleen Review article in Trends in Pharmacological Sciences, 25(12):640-646. Full text retrieved on 2018-01-30.
- ↑ Straub RH et al. (2008). Neuronally released sympathetic neurotransmitters stimulate splenic interferon-γ secretion from T cells in early type II collagen–induced arthritis Article in Arthritis & Rheumatology, 58(11):3450-3460. Full text retrieved on 2018-01-30.
- ↑ Harle P et al. (2005). An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen–induced arthritis Article in Arthritis & Rheumatology, 52(4):1305-1313. Full text retrieved on 2018-01-30.
- ↑ Straub RH et al. (1996). Neuroimmune control of interleukin-6 secretion in the murine spleen. Differential β-adrenergic effects of electrically released endogenous norepinephrine under various endotoxin conditions Article in Journal of Neuroimmunology, 71(1-2):37-43. Abstract retrieved on 2018-01-30.
- ↑ 13.0 13.1 Miller LE et al. (2000). The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages Article in The FASEB Journal, 14:2097-2107. Full text retrieved on 2018-01-30.
- ↑ Jenei-Lanzl Z et al. (2015). Anti-inflammatory effects of cell-based therapy with tyrosine hydroxylase-positive catecholaminergic cells in experimental arthritis Article in Ann Rheum Dis, 74:444-451. Full text retrieved on 2018-01-30.
- ↑ Schmidt M et al. (2009). Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis Article in Arthritis Rheum, 60:2913-2922 (2009). Abstract retrieved from PubMed on 2018-01-30.
- ↑ Straub RH. (2007). The Complex Role of Estrogens in Inflammation Review article in Endocrine Reviews, 28(5):521-574. Full text retrieved on 2018-01-30.
- ↑ Stark K et al. (2015). CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women Article in Arthritis Research & Therapy, 17:56. Full text retrieved on 2018-01-30.
- ↑ Straub RH et al. (2008). Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti–tumor necrosis factor therapy in rheumatoid arthritis Article in Arthritis & Rheumatism, 58(4):976-984. Full text retrieved on 2018-01-30.
- ↑ Straub RH et al. (2002). Inadequately Low Serum Levels of Steroid Hormones in Relation to Interleukin-6 and Tumor Necrosis Factor in Untreated Patients With Early Rheumatoid Arthritis and Reactive Arthritis Article in Arthritis & Rheumatism, 46(3):654-662. Full text retrieved on 2018-01-30.
- ↑ Straub RH, Besedovsky HO. (2003). Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases Review article in The FASEB Journal, 17:2176-2183. Full text retrieved on 2018-01-30.
- ↑ Straub RH et al. (2010). Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases Review article in Journal of Internal Medicine, 267(6):543-560. Full text retrieved on 2018-01-30.
- ↑ Straub RH. (2011). How Energy Shifts Lead to Systemic Illness Review article in The Rheumatologist. Full text retrieved on 2018-01-30.
- ↑ Straub RH. (2012). Evolutionary medicine and chronic inflammatory state — known and new concepts in pathophysiology Review article in Journal of Molecular Medicine, 90:523-534. Full text retrieved on 2018-01-30.
- ↑ Straub RH. (2014). Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases Review article in Arthritis Research & Therapy, 16(Suppl 2):S4. Full text retrieved on 2018-01-30.
- ↑ 25.0 25.1 Nierengarten MB. (2014). Evolutionary Medicine Provides Insight into the Chronic Inflammatory State Note Rheumatologists at the 2013 ACR/ARHP Annual Meeting Article in The Rheumatologist reporting on the Hench-Lecture of the ACR/ARHP 2013 in San Diego. Full text retrieved on 2018-01-30.
- ↑ 26.0 26.1 Straub RH. (2015). The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae Textbook. Elsevier, ISBN 978-0128033210 Search this book on .
- ↑ Straub RH. (2017). The brain and immune system prompt energy shortage in chronic inflammation and ageing Review article in Nature Reviews Rheumatology 13, 743–751. Abstract retrieved on 2018-01-30.
- ↑ 28.0 28.1 Straub RH. (2018). Altern, Muedigkeit und Entzuendungen verstehen: Wenn Immunsystem und Gehirn um die Energie im Koerper ringen Textbook. Springer, ISBN 978-3662557860 Search this book on .. Website of Springer. Retrieved on 2018-01-30.
- ↑ spokesman of the German Endocrine Immune Brain Network Website of the German Endocrine Brain Immune Network. Retrieved on 2018-01-30.
- ↑ Spokesman of the study group Neuroendocrine Immunology Website of the German Society of Immunology. Retrieved on 2018-01-30.
- ↑ DFG Forschergruppe FOR696 Website of the Research Unit FOR696 at the University Hospital Regensburg. Retrieved on 2018-01-30.
- ↑ Past Presidents Website of the PNIRS. Retrieved on 2018-01-30.
- ↑ Annual report of the Department of Internal Medicine I Website of the University Hospital Regensburg. Retrieved on 2018-01-30.
- ↑ GEPRIS – DFG founded projects Website of the DFG. Retrieved on 2018-01-30.
- ↑ Articles in PubMed Website of PubMed using the given search strategy. Retrieved 2018-01-30.
- ↑ Articles in Google scholar Website of Google Scholar. Retrieved on 2018-01-30.
- ↑ Textbook Rheumatology, chapter 22 Website of Google books. Retrieved on 2018-01-30.
- ↑ Kelley Textbook of Rheumatology, chapter 29 Website of Google books. Retrieved on 2018-01-30.
- ↑ Annual report of the EULAR study group Website of the European League Against Rheumatism (EULAR). Retrieved on 2018-01-30.
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