Richard Kremer
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Richard Kremer, MD, PhD, FRCPC is a physician-scientist who specializes in Endocrinology and Laboratory Medicine.[1][2]. Kremer is currently Professor of medicine at McGill University in Montreal, Quebec, Canada[1]. He is also a Senior Scientist at the Research Institute of the McGill University Health Centre at its Centre for Translational Biology[3]. Kremer is also Director of the Bone and Mineral Unit (McGill Department of Medicine) and Academic Director (McGill Division of Medical Biochemistry Centre for Bone and Periodontal Research) at the McGill University Health Centre,[2][1][1] and past Co-Director of the Musculoskeletal Axis. Kremer is also a full member of the Canadian Institutes of Health Research's (CIHR) College of Reviewers [4].
Education[edit]
Kremer was born in Paris, France, and received his MD and PhD degrees at the Pierre et Marie Curie University of Paris.[1] He then completed his internal medicine and endocrinology residency Pitié-Salpêtrière Hospital in Paris. Kremer later moved to Canada where he completed further residency training in Endocrinology and Laboratory Medicine at the Montreal General, Royal Victoria, and Ottawa Civic Hospitals[1]. He would go on to pursue his research training at the Royal Victoria Hospital where he joined as a full-time physician in 1989[1].
Career[edit]
Research on the Parathyroid Hormone-Related Protein (PTHrP)[edit]
Kremer was credited for creating the antibodies that blocked the Parathyroid Hormone-Related Protein (PTHrP) in a widely reported study on Pancreatic Cancer[5] [6] [7][8][9][10][11]. Dr. Kremer previously discovered PTHrP's initiating role in Breast Cancer and its progression which could also be blocked by anti-PTHrP antibodies as was reported in 2011 [12] [13]. Dr. Kremer's research on PTHrP has been impactful and he is considered a top 10 researcher in the field worldwide, having been ranked number 3 worldwide in scholarly output between 2016 and 2021 in the same field[14].
Research on bone[edit]
Kremer and colleagues reported that women who use oral bisphosphonates to prevent osteoporosis may also be at lower risk of skeletal complications of breast cancer [15][16] [17][18][19][20][21][22]. Dr. Kremer was also part of the Canadian Institute of Health Research's (CIHR) 2009 Final Report on Bone Health [23].
Research on Vitamin D[edit]
Kremer has also been involved in research on vitamin D which led to the discovery of a phenomenon known as "vitamin D resistance in cancer" [24][25][26][27] as a consequence of ras-induced phosphorylation of the retinoid X receptor (RXR) which disrupts its heterodimeric association with the vitamin D receptor (VDR). Dr. Kremer and his colleague Dr. Vicente Gilsanz were the first to report the clear link between vitamin D levels and accumulation of fat in muscle tissue in 2010, which was widely reported as a ground-breaking study[28][29][30][31][32][33][34]. This study by Dr. Kremer and colleagues showed the inverse relationship between vitamin D and fat, which demonstrated that people with more fat were also likely to be vitamin D deficient [30][31][35]. On a similar line of inquiry, earlier studies by Dr. Kremer and colleagues demonstrated the link between a lack of vitamin D and weight gain and stunted growth in girls [36][37][38].
Honours and awards[edit]
Kremer received the Chercheur Boursier National award from the Fond de la Recherche en Sante du Quebec in 2007[39] and the Catherine Coyne Memorial Fellowship Award in 2017[40]. He was also nominated as a Fellow of the Royal Society of Medicine and the CIHR College of Reviewers in 2017[40]. In 2019, Dr. Kremer was made a fellow of the Royal College of Physicians and Surgeons of Canada [41]. In 2021, Dr. Kremer was recognized by the American Association of Cancer Research (AACR) as a long term member (25+ years), having been a member for 29 years [42].
Publications and Editing[edit]
Publications[edit]
Kremer has published over 110 original research articles in peer-reviewed journals and his work has recorded between 4200 and 7600 citations as measured by reputable indices[43][44][45].
Editing[edit]
Kremer and colleagues Johng Rhim and Anatoly Dritschilo edited the 2019 edition of Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging[46] and the 2012 edition of Human Cell Transformation: Role of Stem Cells and the Microenvironment [47]
Editorial Boards[edit]
Kremer is an associate editor of Frontiers in Bone Research and has made editorial contributions for Frontiers in Endocrinology [48]. He is also an associate editor of the Journal of Osteoporosis and on the editorial boards of the Journal of Osteoporosis and Physical Activity, World Journal of Orthopedics, and the American Journal of Cancer Research[40].
Conferences[edit]
Kremer together with his colleagues Rhim and Dritschilo organized the "Human Cell Transformation" International Conference that was held in Montreal, Quebec in 2018[49]. Dr Kremer was on the organizing committee for the Second World Congress on Cancer Research and Therapy, as well as having been an invited speaker for that conference which was held in San Diego, California in October 2017 [50][51]
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Richard Kremer". Division of Endocrinology & Metabolism. Retrieved 2021-05-14.
- ↑ 2.0 2.1 "Dr. Richard Kremer". Division of Experimental Medicine. Retrieved 2021-05-14.
- ↑ "Richard Kremer, MD, PHD". Unknown parameter
|url-status=ignored (help) - ↑ Government of Canada, Canadian Institutes of Health Research (September 18, 2018). "College of Reviewers - Membership List". cihr-irsc.gc.ca.
- ↑ Center, Columbia University Irving Medical. "A new therapeutic vulnerability in pancreatic cancer". medicalxpress.com.
- ↑ "Scientists Reveal a New Therapeutic Vulnerability in Pancreatic Cancer". Columbia University Irving Medical Center. March 11, 2021.
- ↑ "Loss of PTHrP hormone can prevent metastases, improve survival in mice with pancreatic cancer". News-Medical.net. July 1, 2021.
- ↑ Jackson, Christina (July 2, 2021). "Mouse Study Reveals New Therapeutic Target in Pancreatic Cancer".
- ↑ "Scientists reveal a new therapeutic vulnerability in pancreatic cancer". EurekAlert!.
- ↑ "Two-Pronged Attack Prevents Pancreatic Cancer Growth and Metastasis". Cancer Research from Technology Networks.
- ↑ "Scientists reveal a new therapeutic vulnerability in pancreatic cancer". Science Codex. July 1, 2021.
- ↑ "New target identified to stop the spread of breast cancer". ScienceDaily.
- ↑ "New target identified to stop the spread of breast cancer | Newsroom - McGill University".
- ↑ "Welcome". id.elsevier.com.
- ↑ "Validate User". academic.oup.com.
- ↑ https://www.hmpgloballearningnetwork.com/site/pln/articles/oral-bisphosphonates-tied-lower-risk-skeletal-metastasis-breast-cancer
- ↑ "Osteoporosis treatment reduces risk of breast cancer bone metastases in first study of its kind". October 15, 2014.
- ↑ "Osteoporosis treatment may also benefit breast cancer patients". EurekAlert!.
- ↑ "Osteoporosis treatment may also benefit breast cancer patients". ScienceDaily.
- ↑ "Osteoporosis drug may help breast cancer patients: Study". ottawasun.
- ↑ "A common osteoporosis medication may improve survival in breast cancer patients | NEWS.am Medicine - All about health and medicine". med.news.am.
- ↑ "Vitamin D - Immune Silver Bullet?". Crisis Magazine. March 12, 2010.
- ↑ Government of Canada, Canadian Institutes of Health Research (May 28, 2010). "The 2009 Bone Health Research Consensus Conference (BHRCC) - CIHR". cihr-irsc.gc.ca.
- ↑ Sebag, M; Henderson, J; Rhim, J; Kremer, R (June 1992). "Relative resistance to 1,25-dihydroxyvitamin D3 in a keratinocyte model of tumor progression". Journal of Biological Chemistry. 267 (17): 12162–12167. doi:10.1016/s0021-9258(19)49818-9. ISSN 0021-9258.
- ↑ Solomon, Cynthia; White, John H.; Kremer, Richard (1999-06-15). "Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3–dependent signal transduction by phosphorylating human retinoid X receptor α". Journal of Clinical Investigation. 103 (12): 1729–1735. doi:10.1172/jci6871. ISSN 0021-9738.
- ↑ Macoritto, Michael; Nguyen-Yamamoto, Loan; Huang, Dao Chao; Samuel, Sara; Yang, Xian Fang; Wang, Tian Tian; White, John H.; Kremer, Richard (February 2008). "Phosphorylation of the Human Retinoid X Receptor α at Serine 260 Impairs Coactivator(s) Recruitment and Induces Hormone Resistance to Multiple Ligands". Journal of Biological Chemistry. 283 (8): 4943–4956. doi:10.1074/jbc.m707517200. ISSN 0021-9258.
- ↑ Jusu, Sylvester; Presley, John F.; Kremer, Richard (January 2017). "Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes". Journal of Biological Chemistry. 292 (4): 1490–1509. doi:10.1074/jbc.m116.758185. ISSN 0021-9258.
- ↑ https://www.cbc.ca/news/canada/montreal/epidemic-of-vitamin-d-deficiency-muhc-study-1.887027
- ↑ "Low vitamin D linked to fat buildup". March 29, 2010.
- ↑ 30.0 30.1 "Low levels of vitamin D linked to muscle fat, decreased strength in young people". EurekAlert!.
- ↑ 31.0 31.1 "Low levels of vitamin D linked to muscle fat, decreased strength in young people". ScienceDaily.
- ↑ "Vitamin D deficiency leads to obesity". Hindustan Times. March 9, 2010.
- ↑ "Muscle Fat, Reduced Strength Linked to Low Vitamin D Levels". Medindia. March 8, 2010.
- ↑ "Ten per cent of Canadians have low vitamin D levels". CTVNews. March 23, 2010.
- ↑ ICI.Radio-Canada.ca, Zone Aucun thème sélectionné-. "Carence majeure en vitamine D". Radio-Canada.ca.
- ↑ Perets, Abbi; Perets, Abbi (January 22, 2009). "The importance of sunshine".
- ↑ "Lack of vitamin D causes weight gain and stunts growth in girls". medicalxpress.com.
- ↑ "Vitamin D | Weight Gain In Young Women - Life Extension". www.lifeextension.com.
- ↑ "SIGNES VITAUX". studylibfr.com.
- ↑ 40.0 40.1 40.2 "McGill Department of Medicine Annual Report 2017" (PDF). Unknown parameter
|url-status=ignored (help) - ↑ "Directory Search". rclogin.royalcollege.ca.
- ↑ https://www.aacr.org/wp-content/uploads/2021/05/2104015A_Mem_LongTermMem_Recog_2.pdf[bare URL PDF]
- ↑ "Richard Kremer". scholar.google.com.
- ↑ "Scopus preview - Kremer, Richard - Author details - Scopus". www.scopus.com.
- ↑ "Richard Kremer's ResearchGate profile".
- ↑ Rhim, Johng S.; Dritschilo, Anatoly; Kremer, Richard (October 1, 2019). Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging. Springer Nature. ISBN 9783030222543 – via Google Books. Search this book on
- ↑ Rhim, Johng S.; Kremer, Richard, eds. (April 8, 2012). "Human Cell Transformation". Advances in Experimental Medicine and Biology. 720. doi:10.1007/978-1-4614-0254-1. ISBN 978-1-4614-0253-4. Unknown parameter
|s2cid=ignored (help) - ↑ "Loop | Richard Kremer". loop.frontiersin.org.
- ↑ "McGill Department of Medicine 2018 Annual Report" (PDF). Unknown parameter
|url-status=ignored (help) - ↑ https://www.mcgill.ca/deptmedicine/files/deptmedicine/2017_mcgill_university_department_of_medicine_annual_report_0.pdf[bare URL PDF]
- ↑ https://www.mcgill.ca/deptmedicine/files/deptmedicine/medicineannualreport2017_3dec2018_web.pdf[bare URL PDF]
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