Richard S. Isaacson
Richard S. Isaacson is an American neurologist who focuses on the prevention and treatment of Alzheimer's disease and dementia. He founded the first Alzheimer's prevention clinic in the U.S.[1][2]
Early life and education
Isaacson was raised in Commack, New York. He collected baseball cards and played the cello and bass guitar. Isaacson graduated from Commack High School and attended the University of Missouri–Kansas City.[3] He enrolled at the age of 17 and earned his Bachelor of Arts degree in liberal arts at the age of 19 and his medical degree at the age of 23.[4][5] Isaacson completed his internship at the University of Miami and residency at the Beth Israel Deaconess Medical Center and Harvard Medical School.[3]
Career
Isaacson is a neurologist focused on the prevention and treatment of Alzheimer's disease and dementia. He has been the director of the Alzheimer's Prevention Clinic in the Center for Brain Health at Florida Atlantic University's (FAC) Charles E. Schmidt College of Medicine.[6] He is the director of research at the Institute for Neurodegenerative Diseases (IND) in Boca Raton, Florida. He founded and was director of the nation's first clinic focused on Alzheimer's prevention at Weill Cornell Medicine and NewYork-Presbyterian Hospital in New York City in 2013,[7] before relocating the program to Florida in 2021.[8] As part of the clinic's Alzheimer's Disease and Memory Disorders Program, Isaacson helped create customized treatment plans for people who have completed genetic testing and showed a greater risk of developing Alzheimer's disease.[9]
Isaacson wrote the book Alzheimer's Treatment, Alzheimer's Prevention: A Patient and Family Guide. He was the associate professor of clinical neurology, vice chair of education, and education director of the McKnight Brain Institute in the neurology department at the University of Miami's Miller School of Medicine at the time.[10] He and Christopher N. Ochner later wrote The Alzheimer's Prevention and Treatment Diet: Using Nutrition to Combat the Effects of Alzheimer's Disease (2016).[11]
Sanjay Gupta has described Isaacson as "a pioneer in preventive therapies for dementia".[12] In 2022, Isaacson was an adjunct associate professor of neurology at Weill Cornell.[13] He has been a member of the board of trustees of the McKnight Brain Research Foundation[14] and the scientific advisory board of Pershing Square Philanthropies.[15] He is the director of the Precision Prevention Program at Atria Health Institute.[5]
Research
According to CNN, Isaacson's research "has shown that following a dozen or more lifestyle interventions, when practiced 60% or more of the time, can improve cognitive function, especially in women".[8] A 2019 study by his team at the Alzheimer's Prevention Clinic found cognitive function could be improved from exercise, medication, nutrition, and lowering vascular risk.[16]
Isaacson and his team at Weill Cornell led the first study "to define sex differences in outcomes of tailored Alzheimer's disease clinical interventions", according to SciTech.[17] The study assessed the Comparative Effectiveness Dementia and Alzheimer's Registry (CEDAR) trial led by Isaacson at Weill Medicine in 2015.[18] The team analyzed results in 80 "higher-compliance" participants from the original group of 154, then published findings in the Journal of Prevention of Alzheimer's Disease in 2022 showing "risk reduction care led to greater cognitive improvements in women than men", according to The Independent.[19] In Nature, he and his team have described the cognitive benefits of aerobic exercise, a plant-based diet, quality sleep, strength training, and stress management.[8]
As of 2024, Isaacson was conducting an online National Institutes of Health-funded clinical trial to provide cognitive tests and personalized recommendations via smartphones.[8][20] In 2025, CNN said his research team and partners at five locations in the U.S. and Canada "set forth to evaluate and eventually cross-compare the clinical use of" what Isaacson said could become "the cholesterol test for the brain". His team at the IND is studying approximately 125 individual markers from various commercial and research-based tests.[1]
Personal life
Isaacson has had multiple family members who were diagnosed with Alzheimer's, which influenced his decision to specialize in prevention and treatment of the disease.[4][21][22]
See also
Select publications
- "Effectiveness of a modified Continuum curriculum for medical students: a randomized trial". Neurology. 76 (2): 125–30. January 11, 2011 – via PubMed.
- Isaacson, Richard S. (2012). Alzheimer's Treatment, Alzheimer's Prevention: A Patient and Family Guide : Thirty Questions Answered by Alzheimer's Expert. Search this book on
- Isaacson, Richard S.; Ochner, Christopher N. (2016). The Alzheimer's Prevention & Treatment Diet: Using Nutrition to Combat the Effects of Alzheimer's Disease. Square One Publishers. Search this book on
- "Is Alzheimer's prevention possible today?". Journal of the American Geriatrics Society. 65 (10): 2153–2154. August 28, 2017 – via PubMed.
- "The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach". Alzheimer's & Dementia. 14 (12): 1, 663–1, 673. November 13, 2018 – via PubMed.
- "Individualized clinical management of patients at risk for Alzheimer's dementia". Alzheimer's & Dementia. Alzheimer's Association. 15 (12): 1, 588–1, 602. October 30, 2019 – via PubMed.
- Isaacson, Richard S. (February 19, 2020). "Why a Brain Doctor Asks About Hormone Replacement Therapy". Medscape.
- "A Missed Opportunity for Dementia Prevention? Current Challenges for Early Detection and Modern-Day Solutions". Journal of Prevention of Alzheimer's Disease. 7: 291–293. April 17, 2020.
References
- ↑ 1.0 1.1 Lua error in Module:Citeq at line 53: attempt to index field 'wikibase' (a nil value)., Wikidata Q137435410
- ↑ Powell, Robert. "Why are women more vulnerable to Alzheimer's disease than men?". Today.
- ↑ 3.0 3.1 Stetka, Bret S. (March 31, 2017). "One Doctor's Mission to Personalize Alzheimer Prevention". Medscape.
- ↑ 4.0 4.1 Attia, Peter (2023). Outlive The Science and Art of Longevity. p. 186. Search this book on
- ↑ 5.0 5.1 "Our Doctors". Atria Health Institute.
- ↑ Lua error in Module:Citeq at line 53: attempt to index field 'wikibase' (a nil value)., Wikidata Q137435414
- ↑ Lua error in Module:Citeq at line 53: attempt to index field 'wikibase' (a nil value)., Wikidata Q137435417
- ↑ 8.0 8.1 8.2 8.3 Lua error in Module:Citeq at line 53: attempt to index field 'wikibase' (a nil value)., Wikidata Q137435433
- ↑ Crowley, Chris; Lodge, Henry S.; Hamilton, Allan J. (2019). Younger Next Year Live Strong, Fit, Sexy, and Smart—Until You’re 80 and Beyond. Workman Publishing Company. p. 336. Search this book on
- ↑ "A Comprehensive Approach to Managing Dementia Patients: Considering the Caregivers". Practical Neurology. April 16, 2012.
- ↑ "The Alzheimer's Prevention and Treatment Diet: Using Nutrition to Combat the Effects of Alzheimer's Disease". Publishers Weekly.
- ↑ Gupta, Sanjay (2022). 12 Weeks to a Sharper You: A Guided Program. p. 7. Search this book on
- ↑ Smith, Dana G. (November 23, 2022). "How to Know if You Have a Genetic Risk for Alzheimer's". The New York Times.
- ↑ "Evelyn F. McKnight Brain Research Foundation 11th Inter-Institutional Meeting 2019" (PDF). McKnight Brain Research Foundation.
- ↑ "Scientific Advisory Board". Pershing Square Philanthropies.
- ↑ Carrington, Alexis E. (January 21, 2021). "Dementia, Alzheimer's not an inevitable part of aging: Study". ABC News.
- ↑ "Men and Women Are Not Created Equal When It Comes to Preventing Alzheimer's Disease". SciTech. May 3, 2022.
- ↑ Galoustian, Gisele (April 26, 2022). "When it comes to preventing Alzheimer's, women respond better than men". Florida Atlantic University.
- ↑ Lua error in Module:Citeq at line 53: attempt to index field 'wikibase' (a nil value)., Wikidata Q137435435
- ↑ "The Retain Your Brain Health Study (RetainYourBrain.com)". National Library of Medicine.
- ↑ "Alzheimer's and Prevention: Who Would Have Thought?". NewYork-Presbyterian Hospital.
- ↑ "2018 Report on Clinical & Scientific Innovations in Neurology & Neurosurgery: Alzheimer's Disease". NewYork-Presbyterian Hospital.
External links
- Richard S. Isaacson publications indexed by Google Scholar
- Publications by Richard S. Isaacson, at ResearchGate
- "Dr. Richard S. Isaacson". Atria Health Institute. November 23, 2020.
- Gupta, Sanjay (May 19, 2024). "I have a family history of Alzheimer's disease. I wanted to understand my own risk". CNN.
External media
- Attia, Peter (October 1, 2018). "#18 – Richard Isaacson, M.D.: Alzheimer's prevention".
- Attia, Peter (November 23, 2020). "#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer's disease prevention—patient and doctor perspectives".
- Isaacson, Richard (September 27, 2023). "Perfecting a Cocktail of Approaches to Treat Alzheimer Disease: Richard Isaacson, MD". NeurologyLive.
- Dr. Gupta discovers the results of an Alzheimer’s risk test, The Last Alzheimer's Patient (CNN, 2024)
- "Armchair Expert with Dax Shepard: Richard Isaacson (on Alzheimer's prevention)". Armchair Expert Podcast. August 8, 2024.
- Can Alzheimer's Be Prevented? The Neuroscience of Aging and Memory Loss on YouTube
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