Stephen C. Frederico
Stephen C. Frederico (born in Rochester, New York) is an American medical researcher and physician-in-training known for his work in neuro-oncology, particularly in the study of brain tumor immunotherapy and targeted therapies for pediatric brain cancers.[1][2][3]
Education
| Stephen C. Frederico | |
|---|---|
| File:Scf pic.jpgScf pic.jpg | |
| Born | Rochester, New York |
| 🏳️ Citizenship | USA |
| 🏫 Education | Bachelor of Arts (BA) in Biology
Master of Science (MS) in Biotechnology Doctor of Medicine (MD) |
| 💼 Occupation | |
| Known for | Immunotherapy and Brain Tumor Research |
Frederico completed his Bachelor of Arts in Biology at the College of Charleston in 2019.[2][4] He subsequently earned a Master of Science in Biotechnology from Johns Hopkins University in 2021.[5] Currently, Frederico is pursuing a Doctor of Medicine at the University of Pittsburgh.[1][3]
During his medical studies, he was awarded the Medical Scholars Research Fellowship by the American Society for Clinical Investigation, facilitating a two-year research fellowship at the Dana-Farber Cancer Institute.[6][7] Between 2023 and 2025, he also completed a Master of Medical Science in Clinical Investigation (MMSCI) at Harvard Medical School.[7][3]
Research
Frederico's research career commenced at the Medical University of South Carolina (MUSC), where he focused on designing nanoparticles for targeted chemotherapy delivery to glioblastoma, an aggressive brain tumor.[8][2] He later received a Cancer Research Training Award from the National Institutes of Health, concentrating on immune-based therapies for brain tumors, particularly gliomas.[9][10]
His research encompasses characterizing the tumor microenvironment,[11][12] developing adoptive cell transfer immunotherapies,[13] and identifying novel antigens for immunotherapeutic targeting.[14] At Dana-Farber, Frederico's thesis investigated the use of tyrosine kinase inhibitors (TKIs) to treat Diffuse Midline Glioma (DMG), a severe pediatric brain cancer, identifying repurposed drugs that, when combined with these inhibitors, enhanced treatment efficacy.[15][6]
Publications
| Title | Authors | Journal name | Publication date |
| Making a cold tumor hot: the role of vaccines in the treatment of glioblastoma[9] | Stephen C Frederico*, John C Hancock*, Emily ES Brettschneider, Nivedita M Ratnam, Mark R Gilbert, Masaki Terabe | Frontiers in Oncology | 2021/5/10 |
| Reversing epigenetic gene silencing to overcome immune evasion in CNS malignancies[10] | Nivedita M Ratnam, Heather M Sonnemann, Stephen C Frederico, Huanwen Chen, Marsha-Kay ND Hutchinson, Tyrone Dowdy, Caitlin M Reid, Jinkyu Jung, Wei Zhang, Hua Song, Meili Zhang, Dionne Davis, Mioara Larion, Amber J Giles, Mark R Gilbert | Frontiers in Oncology | 2021/7/15 |
| Clinical correlates for immune checkpoint therapy: significance for CNS malignancies[16] | Nivedita M Ratnam*, Stephen C Frederico*, Javier A Gonzalez, Mark R Gilbert | Neuro-Oncology Advances | 2021/1 |
| Pre-clinical models for evaluating glioma targeted immunotherapies[17] | Stephen C Frederico, Xiaoran Zhang, Baoli Hu, Gary Kohanbash | Frontiers in Immunology | 2023 |
| Exploring the origin of the cancer stem cell niche and its role in anti-angiogenic treatment for glioblastoma[18] | Funto A Akindona, Stephen C Frederico, John C Hancock, Mark R Gilbert | Frontiers in Oncology | 2022/8/25 |
| Myeloid cells as potential targets for immunotherapy in pediatric gliomas[19] | Stephen C Frederico, Nikhil Sharma, Corbin Darling, Suchet Taori, Alexandra C Dubinsky, Xiaoran Zhang, Itay Raphael, Gary Kohanbash | Frontiers in Pediatrics | 2024/3/8 |
Awards and Recognition
Frederico's contributions to cancer research have been recognized through several awards, including:
- Medical Scholars Research Fellowship, American Society for Clinical Investigation[7]
- Jack & Fay Netchin Medical Student Fellowship, American Brain Tumor Association[1]
- Hillman Medical Student Fellowship for Innovative Cancer Research, Henry L. Hillman Foundation[1]
- Daily Point of Light Award, Points of Light Foundation[20]
- Outstanding Student of the Year Award, College of Charleston[21]
References
- ↑ 1.0 1.1 1.2 1.3 "Stephen Frederico received an American Brain Tumor Association fellowship to study pediatric brain cancer". University of Pittsburgh. 2022-09-01. Retrieved 2025-03-13.
- ↑ 2.0 2.1 2.2 Sausser, Lauren (12 August 2017). "This summer, a College of Charleston student is studying the type of brain tumor that John McCain has". The Post and Courier. Retrieved 13 March 2025.
- ↑ 3.0 3.1 3.2 "'Fox & Friends' wraps up 12 days of giving with Folds of Honor | Fox News Video". Fox News. 2024-12-24. Retrieved 2025-03-17.
- ↑ "Stephen Frederico". meritpages.com. Retrieved 2025-03-17.
- ↑ "The Johns Hopkins University Commencement" (PDF). May 27, 2021.
- ↑ 6.0 6.1 "Pitt Med Student Awarded Research Grant To Study Pediatric Brain Tumors". School of Medicine, University of Pittsburgh. Retrieved 13 March 2025.
- ↑ 7.0 7.1 7.2 Corn, Micaela. "Next gen: Anna Li and Stephen Frederico". PITTMED. Retrieved 13 March 2025.
- ↑ Dickison, Dan (2017-07-06). "CofC Student's Brain Tumor Research May Extend Cancer Patients' Lives". The College Today. Retrieved 2025-03-13.
- ↑ 9.0 9.1 Frederico, Stephen C.; Hancock, John C.; Brettschneider, Emily ES; Ratnam, Nivedita M.; Gilbert, Mark R.; Terabe, Masaki (2021). "Making a cold tumor hot: the role of vaccines in the treatment of glioblastoma". Frontiers in Oncology. 11: 672508. doi:10.3389/fonc.2021.672508. PMC 8141615 Check
|pmc=value (help). PMID 34041034 Check|pmid=value (help). - ↑ 10.0 10.1 Ratnam, Nivedita M.; Sonnemann, Heather M.; Frederico, Stephen C.; Chen, Huanwen; Hutchinson, Marsha-Kay ND; Dowdy, Tyrone; Reid, Caitlin M.; Jung, Jinkyu; Zhang, Wei; Song, Hua (2021). "Reversing epigenetic gene silencing to overcome immune evasion in CNS malignancies". Frontiers in Oncology. 11: 719091. doi:10.3389/fonc.2021.719091. PMID 34336705 Check
|pmid=value (help). - ↑ Nader, Noor E.; Frederico, Stephen C.; Miller, Tracy; Huq, Sakibul; Zhang, Xiaoran; Kohanbash, Gary; Hadjipanayis, Constantinos G. (2024-09-26). "Barriers to T Cell Functionality in the Glioblastoma Microenvironment". Cancers. 16 (19): 3273. doi:10.3390/cancers16193273. ISSN 2072-6694. PMC 11476085 Check
|pmc=value (help). PMID 39409893 Check|pmid=value (help). - ↑ Vincze, Sarah R.; Jaswal, Ambika P.; Frederico, Stephen C.; Nisnboym, Michal; Li, Bo; Xiong, Zujian; Sever, ReidAnn E.; Sneiderman, Chaim T.; Rodgers, Mikayla; Day, Kathryn E.; Latoche, Joseph D.; Foley, Lesley M.; Hitchens, T. Kevin; Frederick, Robin; Patel, Ravi B. (2024-03-04). "ImmunoPET imaging of TIGIT in the glioma microenvironment". Scientific Reports. 14 (1): 5305. Bibcode:2024NatSR..14.5305V. doi:10.1038/s41598-024-55296-y. ISSN 2045-2322. PMC 10912309 Check
|pmc=value (help). PMID 38438420 Check|pmid=value (help). - ↑ Frederico, Stephen; Sneiderman, Chaim; Pollack, Ian; Kohanbash, Gary (November 2022). "222 Developing an adoptive cell transfer immunotherapy for pediatric high-grade gliomas". BMJ Publishing Group Ltd: A236. doi:10.1136/jitc-2022-SITC2022.0222.
- ↑ Frederico, Stephen C.; Raphael, Itay; Nisnboym, Michal; Huq, Sakibul; Schlegel, Brent T.; Sneiderman, Chaim T.; Jackson, Sydney A.; Jain, Anya; Olin, Michael R.; Rood, Brian R.; Pollack, Ian F.; Hwang, Eugene I.; Rajasundaram, Dhivyaa; and Kohanbash, Gary (18 August 2024). "Transcriptomic observations of intra and extracellular immunotherapy targets for pediatric brain tumors". Expert Review of Clinical Immunology. 20 (11): 1411–1420. doi:10.1080/1744666X.2024.2390023. ISSN 1744-666X. PMID 39114885 Check
|pmid=value (help). - ↑ Frederico, Stephen C.; Neyazi, Sina; Gowda, Pruthvi; Nguyen, Cuong; Trissal, Maria; Portero, Erika P.; Haley-Read, John-Paul; Anderson, Emily P.; Thomas, Craig J.; Danial, Nika N.; Filbin, Mariella G. (June 2024). "Revealing and targeting metabolic drivers contributing to treatment escape in diffuse midline glioma". Journal of Clinical Oncology. 42 (16_suppl): 10038. doi:10.1200/JCO.2024.42.16_suppl.10038. ISSN 0732-183X.
- ↑ Ratnam, Nivedita M.; Frederico, Stephen C.; Gonzalez, Javier A.; Gilbert, Mark R. (2021). "Clinical correlates for immune checkpoint therapy: significance for CNS malignancies". Neuro-Oncology Advances. 3 (1): vdaa161. doi:10.1093/noajnl/vdaa161. PMID 33506203 Check
|pmid=value (help). - ↑ Frederico, Stephen C.; Zhang, Xiaoran; Hu, Baoli; Kohanbash, Gary (2023). "Pre-clinical models for evaluating glioma targeted immunotherapies". Frontiers in Immunology. 13: 1092399. doi:10.3389/fimmu.2022.1092399. PMC 9870312 Check
|pmc=value (help). PMID 36700223 Check|pmid=value (help). - ↑ Akindona, Funto A.; Frederico, Stephen C.; Hancock, John C.; Gilbert, Mark R. (2022). "Exploring the origin of the cancer stem cell niche and its role in anti-angiogenic treatment for glioblastoma". Frontiers in Oncology. 12: 947634. doi:10.3389/fonc.2022.947634. PMC 9454306 Check
|pmc=value (help). PMID 36091174 Check|pmid=value (help). - ↑ Frederico, Stephen C.; Sharma, Nikhil; Darling, Corbin; Taori, Suchet; Dubinsky, Alexandra C.; Zhang, Xiaoran; Raphael, Itay; Kohanbash, Gary (2024). "Myeloid cells as potential targets for immunotherapy in pediatric gliomas". Frontiers in Pediatrics. 12: 1346493. doi:10.3389/fped.2024.1346493. PMC 10960498 Check
|pmc=value (help). PMID 38523840 Check|pmid=value (help). - ↑ Solis, Brenda. "College Baseball Athlete Hangs Up His Cleats to Offer Hope to Brain Tumor Patients and Their Families". Points of Light. Retrieved 2025-03-13.
- ↑ Kerr, Amanda (2018-03-29). "2018 ExCEL Awards Winners Announced". The College Today. Retrieved 2025-03-13.
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