Thomas John Martin
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| Professor Emeritus Thomas John Martin AO[1] MD[1] DSC[1] FRACP[1] FRCPA[1] FAA[1] FRS[1] | |
|---|---|
| Born | Thomas John "Jack" Martin January 24, 1937 |
| 🏫 Education | University of Melbourne[2][3] Degrees: |
| 🎓 Alma mater | University of Melbourne |
| 💼 Occupation | |
| Known for | Discovery of parathyroid hormone-related protein (PTHrP) |
Thomas John "Jack" Martin FRACP[1] FRCPA[1] is an Australian pathologist, emeritus professor of medicine, physician and academic at University of Melbourne,[2][3] and researcher who, in 1987, by leading a former team of researchers at the same university, discovered a proteinaceous hormone called parathyroid hormone-related protein (PTHrP).[5][6] In September 2005, further research was conducted by the team of Dengshun Miao[7] and David Goltzman at the Calcium Research Laboratory and Department of Medicine, Royal Victoria Hospital of the McGill University Health Centre, and others.[7]
Martin is a member of Natalie A. Sims's laboratory[8] at Saint Vincent's Institute of Medical Research.[9] He works in the institute's Division of Medicine, Dentistry and Health Sciences, and his primary interest is cell biology of bones.[4]
Early life[edit]
![[icon]](/File:Wiki_letter_w_cropped.svg){kind=small} | This section needs expansion. You can help by adding to it. (October 2022) |
Education[edit]
Career[edit]
Martin was the director of St Vincent’s Institute from 1988 to 2002.[10]
In September 2005, Martin found that PTHrP produced by osteoblasts is a physiological regulator of bone formation.[11]
In July 2022, Martin and his current team at Natalie Sims's lab, after much research on mice, found that deletion of the gene that codes for a receptor protein called granulocyte colony-stimulating factor receptor (G-CSF) increases physiological dysfunction of cortical bones of mice having hyperactivated STAT3 protein in their bone cells.[12] Cortical bone maturation depends on SOCS3-mediated suppression of IL-6 cytokine-induced STAT3 phosphorylation in osteocytes, the cellular network embedded in bone matrix. They concluded that G-CSF has a major role in replacing condensed trabecular bone with lamellar bone during cortical bone formation.[12]
Personal life[edit]
Awards and honours[edit]
| Year | Award |
|---|---|
| 1969 | Fellow of the Royal Australasian College of Physicians (FRACP)[2] |
| 1971 | Selwyn Smith Prize for medical research[2] |
| 1974 | Eric Susman Prize received from the Royal Australasian College of Physicians[2] |
| 1990 | Lemberg Medal received from the Australian Biochemical Society[2] |
| 1992 |
|
In August 2022, an award "TJ Martin Medal" was named in Martin's honour.[10] The medal was awarded to gastroenterologist Chamara Basnayake at St Vincent’s Hospital for his research into the multidisciplinary treatment of functional gastrointestinal disorders.[10]
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Prof T.J. (Jack) Martin". Saint Vincent's Institute. Archived from the original on October 30, 2022. Retrieved October 30, 2022. Unknown parameter
|url-status=ignored (help) - ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 Centre for Transformative Innovation, Swinburne University of Technology. "Martin, Thomas John (Jack)". Encyclopedia of Australian Science and Innovation. Archived from the original on January 1, 2023. Retrieved October 30, 2022. Unknown parameter
|url-status=ignored (help) - ↑ 3.0 3.1 Fioritti, Nathan (November 22, 2016). "Professor Emeritus Thomas John Martin AO". Faculty of Medicine, Dentistry and Health Sciences. Archived from the original on October 29, 2022. Retrieved October 30, 2022. Unknown parameter
|url-status=ignored (help) - ↑ 4.0 4.1 "Prof Thomas Martin". Find an Expert - University of Melbourne. Archived from the original on November 4, 2022. Retrieved October 29, 2022. Unknown parameter
|url-status=ignored (help) - ↑ Martin TJ, Moseley JM, Gillespie MT (1991). "Parathyroid hormone-related protein: biochemistry and molecular biology". Critical Reviews in Biochemistry and Molecular Biology. 26 (3–4): 377–395. doi:10.3109/10409239109114073. PMID 1935171. Archived from the original on October 17, 2022. Retrieved October 29, 2022. Unknown parameter
|url-status=ignored (help) - ↑ US patent 5460978A, Martin TJ, Moseley JM, Kemp BE, Wettenhall RE, "Protein active in humoral hypercalcemia of malignancy-PthrP", issued October 24, 1995, assigned to University of Melbourne
- ↑ 7.0 7.1 Miao, D.; He, B.; Jiang, Y.; Kobayashi, T.; Sorocéanu, M. A.; Zhao, J.; et al. (September 2005). "Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34". The Journal of Clinical Investigation. 115 (9): 2402–2411. doi:10.1172/JCI24918. PMC 1193882. PMID 16138191.
- ↑ Sims, Natalie A. "Natalie A Sims's Lab". ResearchGate.
- ↑ Martin, Thomas J. "Thomas Martin - Saint Vincent's Institute". ResearchGate. Archived from the original on August 11, 2022. Retrieved October 29, 2022. Unknown parameter
|url-status=ignored (help) - ↑ 10.0 10.1 10.2 "2022 TJ Martin Medal Award Winner". ACMD. Archived from the original on October 30, 2022. Retrieved 2022-10-30. Unknown parameter
|url-status=ignored (help) - ↑ Martin TJ (September 2005). "Osteoblast-derived PTHrP is a physiological regulator of bone formation". The Journal of Clinical Investigation. 115 (9): 2322–2324. doi:10.1172/JCI26239. PMC 1193889. PMID 16138187.
- ↑ 12.0 12.1 Isojima, Tsuyoshi; Walker, Emma C; Poulton, Ingrid J; McGregor, Narelle E; Wicks, Ian P; Gooi, Jonathan H; Martin, T John; Sims, Natalie A (July 20, 2022). "G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes". Journal of Bone and Mineral Research. 37 (10): 1876–1890. doi:10.1002/jbmr.4654. ISSN 0884-0431.
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