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Abdul Waseh Basit

From EverybodyWiki Bios & Wiki



Abdul Waseh Basit
Born
🎓 Alma materUniversity of Bath; The School of Pharmacy, University of London
💼 Occupation
Known for3D printing of pharmaceuticals

Drug delivery

Gastroenterology

Abdul Waseh Basit is a British pharmacist, entrepreneur, inventor and Professor of Pharmaceutics at University College London.[1]. Basit is an internationally leading authority on oral drug delivery, digital health and innovative pharmaceutical technologies such as three-dimensional (3D) printing[2][3]. Basit has founded two spin-out companies from UCL FabRx Ltd[4] and Intract Pharma[5] and invented a number of drug delivery technologies that have entered the clinic. Across his career, Basit has received prestigious awards from the AAPS Young Investigator Award in Pharmaceutics and Pharmaceutical Technology[6], GlaxoSmithKline Innovative Science Award[7] and was listed amongst the World's Most Highly Influential Researchers by Web of Science in 2019[8].

Background[edit]

Basit graduated with a First Class Honours degree in Pharmacy in 1993 from the University of Bath, and undertook his pharmacy pre-registration training at Pfizer Pharmaceuticals, becoming a registered pharmacist in 1994[9][10]. He joined the School of Pharmacy, University of London (now UCL School of Pharmacy) in 1994 where he completed his PhD in Pharmaceutics and was appointed Professor in Pharmaceutics in 2010.

Research & career[edit]

Basit's research work sits at the interface between drug delivery, 3D printing of pharmaceuticals and digital health, and is focused on forging links between basic science and clinical outcomes. His research group spans the personalisation of medicines where they investigate the oral delivery of biologicals[11][12], sex differences in the effects of excipients on drug absorption[13][14], metabolic potential of the intestinal microbiota on drug behaviour[15][16], and are at the fore of developing modern pharmaceutical manufacturing techniques using three-dimensional (3D) printing[17][18][19]. His group pioneered the use of fused deposition modelling (FDM) 3D printing[19] and selective laser sintering (SLS) 3D printing[17] for producing pharmaceutical formulations. He has further invented a number of advanced drug delivery technologies that have been translated into the clinic, including PHLORAL™, DuoCoat™, Opticore™ and Soteria™[20]. Notably, Basit's research group at the UCL School of Pharmacy, along with investment from Tillotts Pharma, have developed the first high dose (1600 mg) mesalazine formulation using their PHLORAL™ and Opticore™ technologies, which guarantees drug release in the colon to revolutionise treatment for inflammatory bowel disease sufferers across the world[21]. This drug product was launched across Europe in December 2018 (Asacol 1600, Yaldigo 1600, Octasa 1600). Basit has authored or co-authored more than 350 papers, book chapters and abstracts, and holds numerous granted patents. Notably, Basit co-edited the world's first educational book on 3D printing of pharmaceuticals[22]. To date, Basit has attracted over £100 million in investments as a principal investigator (PI) or co-PI[23]. In 2016, Basit was appointed the European editor of the International Journal of Pharmaceutics[24]. He is also an editorial board member of Drug Development and Industrial Pharmacy[25], AAPS PharmSciTech[26], Journal of Drug Delivery Science and Technology[27], and Pharmaceutics[28].

Entrepreneurship[edit]

FabRx[edit]

In 2014, Basit founded FabRx with Simon Gaisford, Alvaro Goyanes Goyanes, and Bill Lindsay. FabRx is a biotechnology company specialising in the development of 3D printing technology for medicines and medical devices. In 2017, FabRx was awarded the TCT Best Start-Up Award[29]. In 2019, FabRx was awarded over £600,000 from Innovate UK to develop the world's first 3D printer for the production of personalised medicines[30]. In September 2019, FabRx successfully completed the world's first-in-human clinical study using its proprietary Printlets™ technology[31]

Intract Pharma[edit]

In 2016, Basit founded Intract Pharma with Vipul Yadav and Bill Lindsay. Intract Pharma is a pharmaceutical company that provides a range of licensable technologies for targeted delivery in the gastrointestinal tract. In 2018, Intract Pharma was awarded over £1.4 million from Innovate UK to develop a scalable manufacturing process for novel oral antibody products using its proprietary Soteria technology[32][33]. In the same year, Intract Pharma received an award from the Bill & Melinda Gates Foundation to fund investigation of its Soteria technology as a means to stabilise orally-administered therapeutic antibodies to fight against diarrhoeal diseases in children in the developing world[34]. In December 2018, Basit and Intract Pharma launched the first product incorporating PHLORAL™, called Yaldigo®/Asacol 1600[35]. The product, which is marketed by Tillotts Pharma AG, Switzerland, is a novel therapeutic for the treatment of ulcerative colitis which incorporates Phoral to facilitate targeting of mesalazine to the site of the disease in the colon.

Awards & Honours[edit]

Selected awards received by Basit include:

  • 2004 American Association of Pharmaceutical Scientists Young Investigator Award in Pharmaceutics and Pharmaceutical Technology.[6]
  • 2014 Academy of Pharmaceutical Sciences AstraZeneca Award.[36]
  • 2017 Academy of Pharmaceutical Sciences Science Chairman.[37]
  • 2019 GlaxoSmithKline Innovative Science Award.[7]
  • 2019 Web of Science Group World’s Most Highly Cited Researchers.[8]

References[edit]

  1. ↑ UCL (2018-04-25). "Professor Abdul Basit". UCL School of Pharmacy. Retrieved 2020-01-07.
  2. ↑ "Abdul Basit - Google Scholar Citations". scholar.google.co.uk. Retrieved 2020-01-07.
  3. ↑ "Abdul W Basit, Author at ONdrugDelivery". ONdrugDelivery. Retrieved 2020-01-07.
  4. ↑ "Abdul Basit". FabRx. Retrieved 2020-01-07.
  5. ↑ "About Us". Intract Pharma. Retrieved 2020-01-07.
  6. ↑ 6.0 6.1 "Our Advisors". Biokier. Retrieved 2020-01-07.
  7. ↑ 7.0 7.1 Andy. "Academy Awards Application". The Academy of Pharmaceutical Sciences. Retrieved 2020-01-07.
  8. ↑ 8.0 8.1 UCL (2019-11-20). "Three Pharmacy academics listed amongst World's Most Influential Researchers by Web of Science". UCL School of Pharmacy. Retrieved 2020-01-07.
  9. ↑ "Professor Abdul Basit". www.ucl.ac.uk. Retrieved 2020-01-07.
  10. ↑ "Joint Pharmaceutical Analysis Group". www.jpag.org. Retrieved 2020-01-07.
  11. ↑ Yadav, Vipul; Varum, Felipe; Bravo, Roberto; Furrer, Esther; Basit, Abdul W. (2016-04-11). "Gastrointestinal stability of therapeutic anti-TNF α IgG1 monoclonal antibodies". International Journal of Pharmaceutics. 502 (1): 181–187. doi:10.1016/j.ijpharm.2016.02.014. ISSN 0378-5173. PMID 26892815.
  12. ↑ Yadav, Vipul; Varum, Felipe; Bravo, Roberto; Furrer, Esther; Bojic, Daniela; Basit, Abdul W. (2016-10-01). "Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets". Translational Research. 176: 38–68. doi:10.1016/j.trsl.2016.04.009. ISSN 1931-5244. PMID 27220087.
  13. ↑ Freire, Ana C.; Basit, Abdul W.; Choudhary, Rahul; Piong, Chee W.; Merchant, Hamid A. (2011-08-30). "Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery". International Journal of Pharmaceutics. 415 (1): 15–28. doi:10.1016/j.ijpharm.2011.04.069. ISSN 0378-5173. PMID 21640175.
  14. ↑ Mai, Yang; Dou, Liu; Madla, Christine M.; Murdan, Sudaxshina; Basit, Abdul W. (May 2019). "Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but Not Female Rats". Pharmaceutics. 11 (5): 228. doi:10.3390/pharmaceutics11050228. PMID 31083453.
  15. ↑ Sousa, Tiago; Paterson, Ronnie; Moore, Vanessa; Carlsson, Anders; Abrahamsson, Bertil; Basit, Abdul W. (2008-11-03). "The gastrointestinal microbiota as a site for the biotransformation of drugs". International Journal of Pharmaceutics. 363 (1): 1–25. doi:10.1016/j.ijpharm.2008.07.009. ISSN 0378-5173. PMID 18682282.
  16. ↑ Wilson, Peter J; Basit, Abdul W (2005-08-26). "Exploiting gastrointestinal bacteria to target drugs to the colon: An in vitro study using amylose coated tablets". International Journal of Pharmaceutics. Festschrift in Honour of the 65th Birthday of Professor A.T. Florence. 300 (1): 89–94. doi:10.1016/j.ijpharm.2005.05.010. ISSN 0378-5173. PMID 16023805.
  17. ↑ 17.0 17.1 Fina, Fabrizio; Goyanes, Alvaro; Gaisford, Simon; Basit, Abdul W. (2017-08-30). "Selective laser sintering (SLS) 3D printing of medicines". International Journal of Pharmaceutics. 529 (1): 285–293. doi:10.1016/j.ijpharm.2017.06.082. ISSN 0378-5173. PMID 28668582.
  18. ↑ Goyanes, Alvaro; Buanz, Asma B. M.; Basit, Abdul W.; Gaisford, Simon (2014-12-10). "Fused-filament 3D printing (3DP) for fabrication of tablets". International Journal of Pharmaceutics. 476 (1): 88–92. doi:10.1016/j.ijpharm.2014.09.044. ISSN 0378-5173. PMID 25275937.
  19. ↑ 19.0 19.1 Goyanes, Alvaro; Chang, Hanah; Sedough, Daniel; Hatton, Grace B.; Wang, Jie; Buanz, Asma; Gaisford, Simon; Basit, Abdul W. (2015-12-30). "Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing". International Journal of Pharmaceutics. 496 (2): 414–420. doi:10.1016/j.ijpharm.2015.10.039. ISSN 0378-5173. PMID 26481468.
  20. ↑ "Abdul Waseh Basit Inventions, Patents and Patent Applications - Justia Patents Search". patents.justia.com. Retrieved 2020-01-07.
  21. ↑ UCL (2019-12-11). "Novel therapy for treatment of inflammatory bowel disease launches in UK as Octasa 1600". UCL School of Pharmacy. Retrieved 2020-01-07.
  22. ↑ Basit, Abdul; Gaisford, Simon, eds. (2018). 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series. Springer International Publishing. ISBN 978-3-319-90754-3. Search this book on
  23. ↑ UCL (2018-04-25). "Professor Abdul Basit". UCL School of Pharmacy. Retrieved 2020-01-30.
  24. ↑ International Journal of Pharmaceutics Editorial Board. Search this book on
  25. ↑ "Drug Development and Industrial Pharmacy". www.tandfonline.com. Retrieved 2020-01-07.
  26. ↑ "Meet the Editorial Advisory Board of AAPS PharmSciTech". springer.com. Retrieved 2020-01-07.
  27. ↑ Journal of Drug Delivery Science and Technology Editorial Board. Search this book on
  28. ↑ "Pharmaceutics". www.mdpi.com. Retrieved 2020-01-07.
  29. ↑ Davies, Sam (2017-12-04). "FabRx launches Kickstarter campaign as it looks to 3D print medicine for children". TCT Magazine. Retrieved 2020-01-07.
  30. ↑ "FabRx Awarded Innovate UK Grant to Design the World's First Personalised Medicine 3D Printer". FabRx. 2019-04-14. Retrieved 2020-01-07.
  31. ↑ "FabRx performs the first clinical study using personalised 3D printed dosage forms to treat children with a rare metabolic disease". FabRx. 2019-09-03. Retrieved 2020-01-07.
  32. ↑ UCL (2019-03-07). "Intract awarded Innovate UK grant to make oral antibody formulation using Soteria® technology". UCL School of Pharmacy. Retrieved 2020-01-07.
  33. ↑ "Intract Pharma awarded £1.4m grant to develop antibodies". EPM Magazine. 2018-12-28. Retrieved 2020-01-07.
  34. ↑ "Intract Pharma to join fight against diarrhoeal diseases in children in the developing world". Intract Pharma. 2018-11-23. Retrieved 2020-01-07.
  35. ↑ "Intract Pharma announces market launch of a first Phloral® colon-targeting product". Intract Pharma. 2019-03-27. Retrieved 2020-01-07.
  36. ↑ UCL (2014-08-21). "Professor Abdul Basit receives Academy of Pharmaceutical Sciences Award". UCL School of Pharmacy. Retrieved 2020-01-07.
  37. ↑ Andy (2019-02-21). "APS PharmSci Conference Blog". The Academy of Pharmaceutical Sciences. Retrieved 2020-01-07.

External links[edit]


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