Alon Korngreen
| Alon Korngreen | |
|---|---|
 Alon Korngreen.jpg Alon Korngreen | |
| Native name | אלון קורנגרין |
| Born | March 21, 1967 Ra'anana, Israel |
| 🏳️ Citizenship | Israeli |
| 🎓 Alma mater | Ben-Gurion University of the Negev, Max Planck Society Bar-Ilan University |
| 💼 Occupation | |
| 👶 Children | 3 |
| 🌐 Website | www |
Alon Korngreen (Hebrew: אלון קורנגרין)(born 1967) is an Israeli biophysicist, who specializes in brain research. Professor at The Mina and Everard Goodman Faculty of life Sciences at Bar-Ilan University and since 2019 head of the Multidisciplinary Gonda Brain Research Center there.[1] His main interest is in the computational capabilities of individual nerve cells in the cerebral cortex and basal ganglia. He also investigates the involvement of dopamine and endocannabinoids in nervous system modulation.[2]
Korngreen work is influencing the brain research for over a decade.[3]
Early life[edit]
Alon Korngreen was born in Ra'anana on March 21, 1967 to David Korngreen, the headmaster of Ostrovsky High School and Tzafrira nee Arigi.[4]
Between 1988 and 1991, he completed his undergraduate studies in chemistry with honors at Ben-Gurion University of the Negev. Between 1991 and 1993, he completed his master's degree in biophysics with honors, in the Department of Chemistry at Ben-Gurion University of the Negev.[2]
Between 1993 and 1997, he completed his postgraduate studies (Doctor) in biophysics with honors, in the Department of Chemistry at Ben-Gurion University of the Negev. The topic of his thesis, written under the supervision of Professor Zvi Priel, was "Investigating the Transformation of Calcium Signals, in Ciliary Cells, by Combined Methods".
Between 1997 and 2001, he completed his postdoctoral fellowship in neurophysiology with Professor Bert Sakmann, winner of the 1991 Nobel Prize in Physiology, at the Max Planck Research Institute in Heidelberg, Germany.[2]
Academic career[edit]
In 2001, he was appointed a lecturer in neurophysiology in the Faculty of Life Sciences, at the Brain Center at Bar-Ilan University. In 2007 he was promoted to senior lecturer. In 2012 he was appointed Associate Professor. In 2018 he was appointed full professor and appointed head of the Multidisciplinary Center for Brain Research.[5]
Research[edit]
Korngreen's study focuses on the physiological mechanisms underlying the functional and computational properties of neurons.[6]
At Korngreen's Cellular Neurophysiology Laboratory at Bar-Ilan University, he and his students are researching some of the basic questions in neuroscience such as: How do neurons process information? What is the neuronal code at the cellular level? How does synaptic integration affect neural computing? To answer these questions they apply electrophysiology and optogenetics of neurons in brain slices with computational techniques in neuroscience. To study circuits in the basic nuclei affected by Parkinson's disease. The interactions between cannabinoids and dopamine in the basic nuclei are also investigated.[6]
He investigates how phenomena such as dendritic integration may allow individual neurons and small neural networks to perform complex functions. Understanding such computational properties requires the simultaneous acquisition of data from multiple cells in a network in the brain or from multiple locations within a single cell. Thus, it also deals with the application and development of physiological and optical techniques that enable the acquisition of parallel data of such types.[7]
In the last decade several computational techniques have been developed in his laboratory aimed at constraining free parameters in computation models for neurons in the cerebral cortex. In two initial projects, different aspects are examined to give answers to the general questions mentioned.
Between 2001 and 2021, Professor Korngreen engaged in brain research at Bar-Ilan University. He has authored about 60 research papers and educated about 20 students in their master's and doctoral studies.[8][9][10][11]
Published works[edit]
Books[edit]
- Korngreen, A. (2016) "Advanced patch-clamp analysis for neuroscientists", Springer Method Series. Springer
Academic Articles[edit]
Professor Korngreen has published about 60 scientific papers, including:
- Korngreen, A. and Sakmann, B. (2000) "Voltage gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients". The Journal of Physiology 525, 621-639 PMID 10856117
- Keren, N. Peled, N. and Korngreen A. (2005). "Constraining compartmental models using multiple voltage-recordings and genetic algorithms". Journal of Neurophysiology 94: 3730-3743 PMID 16093338
- Gurkiewicz, M., and Korngreen, A. (2007). "A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm". PLOS Computational Biology 3(8): e169
- Keren, N., Bar-Yehuda, D., and Korngreen, A. (2009) "Experimentally guided modeling of dendritic excitability in rat neocortical pyramidal neurons". The Journal of Physiology 587: 1413-1437. DOI: 10.1113/jphysiol.2008.167130
- Almog M, Korngreen A. (2014) "A quantitative description of dendritic conductances and its application to dendritic excitation in layer 5 pyramidal neurons". The Journal of Neuroscience 34(1):182-96. DOI: 10.1523/JNEUROSCI.2896-13.2014
- Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A. (2017) "Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus". The Journal of Neuroscience 37(30):7177-7187 PMID 28652413
- Almog M, Korngreen A. (2016) "Is realistic neuronal modeling realistic?" Journal of Neurophysiology 116(5):2180-2209 Is realistic neuronal modeling realistic?
References[edit]
- ↑ "The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center". Bar-Ilan University. Retrieved 2 March 2021.
- ↑ 2.0 2.1 2.2 "Prof. Alon Korngreen". Bar-Ilan University. Retrieved 2 March 2021.
- ↑ Storm, J. F. 2000. "K + Channels And Their Distribution In Large Cortical Pyramidal Neurones". The Journal of Physiology 525 (3): 565-566. doi:10.1111/j.1469-7793.2000.t01-1-00565.x.
Häusser, Michael. 2003. "Revealing The Properties Of Dendritic Voltage-Gated Channels: A New Approach To The Space Clamp Problem". Biophysical Journal 84 (6): 3497-3498. doi:10.1016/s0006-3495(03)75083-8.
Roth, Arnd, and Armin Bahl. 2009. "Divide Et Impera: Optimizing Compartmental Models Of Neurons Step By Step". The Journal of Physiology 587 (7): 1369-1370. doi:10.1113/jphysiol.2009.170944. - ↑ Zamir, Chen (22 May 2018). "Tzafrira Korngreen, died: "Educated an entire generation of children in Raanana"". Ynet. Mynet. Retrieved 2 March 2021.
- ↑ "Gonda Center - Academic Staff". Bar-Ilan University. Retrieved 2 March 2021.
- ↑ 6.0 6.1 "Alon Korngreen Neurophysiology Laboratory". Retrieved 2 March 2021.
- ↑ "NeuroDesign: Between Design and Neuroscience". Shenkar College of Engineering and Design. Retrieved 2 March 2021.
- ↑ "Alon Korngreen". Google Scholar. Retrieved 2 March 2021.
- ↑ "Alon Korngreen". ResearchGate. Retrieved 2 March 2021.
- ↑ "Alon Korngreen". ORCiD. Retrieved 2 March 2021.
- ↑ "Alon Korngreen". Academia. Retrieved 2 March 2021.
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