David Taylor
| David Taylor | |
|---|---|
.jpg) David Taylor (Structural biologist).jpg | |
| Born | |
| 🏳️ Citizenship | American |
| 🎓 Alma mater | Yale University (PhD, 2008-2013) |
| 💼 Occupation | |
| Known for | Structural biology CRISPR complexes and Cas9 |
| 🏅 Awards | Damon Runyon Fellow (2014), CPRIT Scholar (2016), Army Young Investigator (2018) |
| 🌐 Website | cryoem |
| Twitter= | |
David Taylor is a structural biologist at The University of Texas at Austin, where he is an Assistant Professor[1] and CPRIT Scholar[2][3][4] in the College of Natural Sciences.[5]
As an undergraduate at Syracuse University, he was named a Barry Goldwater Scholar[6]. His graduate work with Hongwei Wang uncovered details behind the mechanism of Dicer, an enzyme that processes RNA transcripts into mature microRNA.[7] As a Damon Runyon Cancer Research Foundation Fellow at the University of California, Berkeley, he studied how CRISPR complexes[8][9] and Cas9[10][11][12][13] function by studying their structures using cryo-EM with Jennifer Doudna and Eva Nogales.[14][15][16]
In 2016, he moved to The University of Texas at Austin to begin his faculty career.
Taylor currently studies CRISPR complexes, bacterial machines that target viral nucleic acid for destruction and are used for gene-editing applications, and methods development for cryo-electron microscopy.[17][18][19]
References[edit]
- ↑ "Molecular biology department plans to bring new microscopy technique to UT - The Daily Texan". www.dailytexanonline.com. Retrieved 2019-02-02.
- ↑ "David Taylor — Cancer Prevention and Research Institute of Texas". www.cprit.state.tx.us. Retrieved 2019-02-02.
- ↑ Lee, Steffi (2018-11-21). "Future of taxpayer-funded cancer research in the hands of Texas lawmakers". KXAN. Retrieved 2019-02-02.
- ↑ "New Faculty, New Technology to Strengthen Disease Research at UT Austin". cns.utexas.edu. Retrieved 2019-02-02.
- ↑ "Taylor, David W. (CNS Faculty Profiles)". The University of Texas at Austin.
- ↑ "SU's Taylor named 2007 Goldwater Scholar". SU News. Retrieved 2019-02-02.
- ↑ Taylor, David W.; Ma, Enbo; Shigematsu, Hideki; Cianfrocco, Michael A.; Noland, Cameron L.; Nagayama, Kuniaki; Nogales, Eva; Doudna, Jennifer A.; Wang, Hong-Wei (2013). "Substrate-specific structural rearrangements of human Dicer". Nature Structural & Molecular Biology. 20 (6): 662–670. doi:10.1038/nsmb.2564. ISSN 1545-9985. PMC 3676429. PMID 23624860.
- ↑ "Researchers report on CRISPR-cas surveillance complex that targets RNA". phys.org. Retrieved 2019-02-02.
- ↑ Du Toit, Andrea (2015-04-16). "Structural biology: Where to make the cut". Nature Reviews Microbiology. 13 (5): 251. doi:10.1038/nrmicro3483. ISSN 1740-1534.
- ↑ Pollack, Andrew (2014-03-03). "A Powerful New Way to Edit DNA". The New York Times. ISSN 0362-4331. Retrieved 2019-02-02.
- ↑ Bailey, Scott; Chen, Hongfan (2016-02-19). "Cas9, poised for DNA cleavage". Science. 351 (6275): 811–812. Bibcode:2016Sci...351..811C. doi:10.1126/science.aaf2089. ISSN 0036-8075. PMID 26912877.
- ↑ Krasteva, Petya V. (2014-03-28). "Biochemistry: CRISPR snapshots of a gene-editing tool". Nature Methods. 11 (4): 365. doi:10.1038/nmeth.2912. ISSN 1548-7105. PMID 24818224.
- ↑ "UC Berkeley Scientists Show Structure of CRISPR/Cas9 at Work". GenomeWeb. Retrieved 2019-02-02.
- ↑ Taylor, David W.; Zhu, Yifan; Staals, Raymond H. J.; Kornfeld, Jack E.; Shinkai, Akeo; van der Oost, John; Nogales, Eva; Doudna, Jennifer A. (2015-05-01). "Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning". Science. 348 (6234): 581–585. doi:10.1126/science.aaa4535. ISSN 1095-9203. PMC 4582657. PMID 25837515.
- ↑ Jiang, Fuguo; Taylor, David W.; Chen, Janice S.; Kornfeld, Jack E.; Zhou, Kaihong; Thompson, Aubri J.; Nogales, Eva; Doudna, Jennifer A. (2016-02-19). "Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage". Science. 351 (6275): 867–871. Bibcode:2016Sci...351..867J. doi:10.1126/science.aad8282. ISSN 1095-9203. PMC 5111852. PMID 26841432.
- ↑ Jinek, Martin; Jiang, Fuguo; Taylor, David W.; Sternberg, Samuel H.; Kaya, Emine; Ma, Enbo; Anders, Carolin; Hauer, Michael; Zhou, Kaihong (2014-03-14). "Structures of Cas9 endonucleases reveal RNA-mediated conformational activation". Science. 343 (6176): 1247997. doi:10.1126/science.1247997. ISSN 1095-9203. PMC 4184034. PMID 24505130.
- ↑ Gong, Shanzhong; Yu, Helen Hong; Johnson, Kenneth A.; Taylor, David W. (2018). "DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity". Cell Reports. 22 (2): 359–371. doi:10.1016/j.celrep.2017.12.041. ISSN 2211-1247. PMID 29320733.
- ↑ Verbeke, Eric J.; Mallam, Anna L.; Drew, Kevin; Marcotte, Edward M.; Taylor, David W. (2018-07-03). "Classification of Single Particles from Human Cell Extract Reveals Distinct Structures". Cell Reports. 24 (1): 259–268.e3. doi:10.1016/j.celrep.2018.06.022. ISSN 2211-1247. PMC 6109231. PMID 29972786.
- ↑ Doerr, Allison (15 September 2018). "Taking inventory with shotgun EM". Nature Methods. 15 (9): 649. doi:10.1038/s41592-018-0132-x. ISSN 1548-7105. PMID 30171238.
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