Diego Ghezzi
| Professor Diego Ghezzi | |
|---|---|
 EPFL 2021 Diego Ghezzi Portrait.jpg Diego Ghezzi in 2021 | |
| Born | 1980 (age 43–44) Desio, Italy |
| 🏳️ Citizenship | Italy |
| 💼 Occupation | |
| Known for | Neuroprosthetics |
| 🌐 Website | www.epfl.ch/labs/lne/ |
Diego Ghezzi (born 1980 in Desio, Italy) is a Italian neuroengineer specialized in neuroprosthetics. He is a professor at EPFL (École Polytechnique Fédérale de Lausanne) and the head of the Medtronic Chair in Neuroengineering (LNE) at EPFL's School of Engineering.[1][2]
Career[edit]
Ghezzi studied biomedical engineering at the Polytechnic University of Milan (Politecnico di Milano) and received his Laurea (Master's degree) in 2004. There he then pursued a PhD in bioengineering and graduated in 2007 with a thesis on "Strumenti per la stimolazione ottica di neuroni coltivati in-vitro" (Optical tools to stimulate in-vitro cultured neurons) supervised by Giancarlo Ferrigno.[3] In 2008, he joined the Department of Neuroscience and Brain Technologies at the Istituto Italiano di Tecnologia in Genova to work with Fabio Benfenati as postdoctoral researcher on sound driven and optical synaptic manipulation. He was promoted to a permanent researcher position in 2013.[4][5]
Since 2015 he has been an assistant professor of bioengineering at the EPFL Center for Neuroprosthetics and Institute of Bioengineering, and the head of the Medtronic Chair in Neuroengineering at EPFL's School of Engineering.[1][2]
Research[edit]
Ghezzi's current focus of research is aimed at the development of minimally invasive and replaceable neuroprosthetic devices to enable the restoration of vision in humans. In his transdisciplinary approach he draws on engineering,[6] material sciences,[7] neuroscience,[8][9] and ophthalmology,[10] and covers the developmental steps from basic research up to clinical applications.[11]
Among his specialisations rank device micro fabrication,[12] polymers,[13] organic semiconductors[14], optoelectronic characterization,[15] and biodegradation.[16]
He has developed of a wide-field high-resolution photovoltaic epiretinal prosthesis (POLYRETINA),[17][18] and an intraneural stimulator of the optic nerve (OpticSELINE).[19][20]
Ghezzi's research has been featured in news outlets such as Der Bund,[21] Heidi.News,[22] Le Matin,[23] Physics World,[24] Tech Explorist,[25] The Engineer,[26] The Week,[27] RTS,[28] ScienceDaily,[29] Il Messaggero,[30] the Deutsches Ärzteblatt,[31] and Der Standard.[32]
Distinctions[edit]
Ghezzi is the recipient of the 2014 Global Ophthalmology Awards Program (GOAP) awarded by Bayer HealthCare.[33]
He is an associate editor at the 10th International IEEE EMBS Conference on Neural Engineering (NER 2021), an editorial board member of the Bioengineering panel at PLOS One (since 2018),[34] an editorial board member on the Neuroscience panel at Scientific Reports (since 2018),[35] and was a member of the scientific committee of BMT2016 organized by the Swiss, Austrian and German Societies of Biomedical Engineering.[36]
He is a member of the Swiss Society for Biomedical Engineering (since 2015), The Association for Research in Vision and Ophthalmology (since 2014), the IEEE Engineering in Medicine & Biology Society (since 2014), the Institute of Electrical and Electronics Engineers (since 2014), The Physiological Society of Italy (since 2013), Italian Society for Neuroscience (since 2010), and the Society for Neuroscience (since 2007).[11]
Selected works[edit]
- Gaillet, Vivien; Cutrone, Annarita; Artoni, Fiorenzo; Vagni, Paola; Mega Pratiwi, Ariastity; Romero, Sandra Alejandra; Lipucci Di Paola, Dario; Micera, Silvestro; Ghezzi, Diego (2020). "Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve" (PDF). Nature Biomedical Engineering. 4 (2): 181–194. doi:10.1038/s41551-019-0446-8. PMID 31427779. Unknown parameter
|s2cid=ignored (help) - Ferlauto, Laura; Airaghi Leccardi, Marta Jole Ildelfonsa; Chenais, Naïg Aurelia Ludmilla; Gilliéron, Samuel Charles Antoine; Vagni, Paola; Bevilacqua, Michele; Wolfensberger, Thomas J.; Sivula, Kevin; Ghezzi, Diego (2018). "Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis". Nature Communications. 9 (1): 992. Bibcode:2018NatCo...9..992F. doi:10.1038/s41467-018-03386-7. PMC 5843635. PMID 29520006.
- Iurilli, Giuliano; Ghezzi, Diego; Olcese, Umberto; Lassi, Glenda; Nazzaro, Cristiano; Tonini, Raffaella; Tucci, Valter; Benfenati, Fabio; Medini, Paolo (2012). "Sound-Driven Synaptic Inhibition in Primary Visual Cortex". Neuron. 73 (4): 814–828. doi:10.1016/j.neuron.2011.12.026. PMC 3315003. PMID 22365553. Unknown parameter
|s2cid=ignored (help) - Ghezzi, Diego; Antognazza, Maria Rosa; Dal Maschio, Marco; Lanzarini, Erica; Benfenati, Fabio; Lanzani, Guglielmo (2011). "A hybrid bioorganic interface for neuronal photoactivation". Nature Communications. 2: 166. arXiv:1202.1189. Bibcode:2011NatCo...2..166G. doi:10.1038/ncomms1164. PMID 21266966. Unknown parameter
|s2cid=ignored (help) - Ghezzi, Diego; Antognazza, Maria Rosa; MacCarone, Rita; Bellani, Sebastiano; Lanzarini, Erica; Martino, Nicola; Mete, Maurizio; Pertile, Grazia; Bisti, Silvia; Lanzani, Guglielmo; Benfenati, Fabio (2013). "A polymer optoelectronic interface restores light sensitivity in blind rat retinas". Nature Photonics. 7 (5): 400–406. Bibcode:2013NaPho...7..400G. doi:10.1038/nphoton.2013.34. PMC 4855023. PMID 27158258.
- Maya-Vetencourt, José Fernando; Ghezzi, Diego; Antognazza, Maria Rosa; Colombo, Elisabetta; Mete, Maurizio; Feyen, Paul; Desii, Andrea; Buschiazzo, Ambra; Di Paolo, Mattia; Di Marco, Stefano; Ticconi, Flavia; Emionite, Laura; Shmal, Dmytro; Marini, Cecilia; Donelli, Ilaria; Freddi, Giuliano; MacCarone, Rita; Bisti, Silvia; Sambuceti, Gianmario; Pertile, Grazia; Lanzani, Guglielmo; Benfenati, Fabio (2017). "A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness". Nature Materials. 16 (6): 681–689. Bibcode:2017NatMa..16..681M. doi:10.1038/nmat4874. PMC 5446789. PMID 28250420.
- Contestabile, Andrea; Greco, Barbara; Ghezzi, Diego; Tucci, Valter; Benfenati, Fabio; Gasparini, Laura (2013). "Lithium rescues synaptic plasticity and memory in Down syndrome mice". Journal of Clinical Investigation. 123 (1): 348–361. doi:10.1172/JCI64650. PMC 3533293. PMID 23202733.
- Dal Maschio, Marco; Ghezzi, Diego; Bony, Guillaume; Alabastri, Alessandro; Deidda, Gabriele; Brondi, Marco; Sato, Sebastian Sulis; Zaccaria, Remo Proietti; Di Fabrizio, Enzo; Ratto, Gian Michele; Cancedda, Laura (2012). "High-performance and site-directed in utero electroporation by a triple-electrode probe". Nature Communications. 3: 960. Bibcode:2012NatCo...3..960D. doi:10.1038/ncomms1961. PMC 5972006. PMID 22805567.
References[edit]
- ↑ 1.0 1.1 "Medtronic Chair in Neuroengineering". www.epfl.ch. Retrieved 2021-02-25.
- ↑ 2.0 2.1 "16 new professors at the two Federal Institutes of Technology". www.admin.ch. Retrieved 2021-07-14.
- ↑ Ghezzi, Diego <1980-> (2007). Strumenti per la stimolazione ottica di neuroni coltivati in-vitro = Optical tools to stimulate in-vitro cultured neurons (in italiano). Search this book on
- ↑ Iurilli, Giuliano; Ghezzi, Diego; Olcese, Umberto; Lassi, Glenda; Nazzaro, Cristiano; Tonini, Raffaella; Tucci, Valter; Benfenati, Fabio; Medini, Paolo (February 2012). "Sound-Driven Synaptic Inhibition in Primary Visual Cortex". Neuron. 73 (4): 814–828. doi:10.1016/j.neuron.2011.12.026. PMC 3315003. PMID 22365553.
- ↑ Ghezzi, Diego; Antognazza, Maria Rosa; Dal Maschio, Marco; Lanzarini, Erica; Benfenati, Fabio; Lanzani, Guglielmo (September 2011). "A hybrid bioorganic interface for neuronal photoactivation". Nature Communications. 2 (1): 166. arXiv:1202.1189. Bibcode:2011NatCo...2..166G. doi:10.1038/ncomms1164. ISSN 2041-1723. PMID 21266966. Unknown parameter
|s2cid=ignored (help) - ↑ Thorn, Jacob Thomas; Migliorini, Enrico; Ghezzi, Diego (2020-11-04). "Virtual reality simulation of epiretinal stimulation highlights the relevance of the visual angle in prosthetic vision". Journal of Neural Engineering. 17 (5): 056019. Bibcode:2020JNEng..17e6019T. doi:10.1088/1741-2552/abb5bc. ISSN 1741-2552. PMID 33146146 Check
|pmid=value (help). - ↑ Borda, Eleonora; Ferlauto, Laura; Schleuniger, Jürg; Mustaccio, Alessandro; Lütolf, Fabian; Lücke, Arnold; Fricke, Sören; Marjanović, Nenad; Ghezzi, Diego (March 2020). "All‐Printed Electrocorticography Array for In Vivo Neural Recordings". Advanced Engineering Materials. 22 (3): 1901403. doi:10.1002/adem.201901403. ISSN 1438-1656.
- ↑ Chenais, Naïg Aurelia Ludmilla; Airaghi Leccardi, Marta Jole Ildelfonsa; Ghezzi, Diego (2021-02-01). "Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell". Journal of Neural Engineering. 18 (1): 016016. Bibcode:2021JNEng..18a6016C. doi:10.1088/1741-2552/abcd6f. ISSN 1741-2560. PMID 33232947 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Vagni, Paola; Perlini, Laura E.; Chenais, Naïg A. L.; Marchetti, Tommaso; Parrini, Martina; Contestabile, Andrea; Cancedda, Laura; Ghezzi, Diego (2019-09-10). "Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration". Frontiers in Neuroscience. 13: 945. doi:10.3389/fnins.2019.00945. ISSN 1662-453X. PMC 6748340 Check
|pmc=value (help). PMID 31551698. - ↑ Ghezzi, Diego (February 2020). "Translation of a photovoltaic retinal prosthesis". Nature Biomedical Engineering. 4 (2): 137–138. doi:10.1038/s41551-020-0520-2. ISSN 2157-846X. PMID 32051579 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ 11.0 11.1 "Diego Ghezzi". people.epfl.ch. Retrieved 2021-02-26.
- ↑ Maya-Vetencourt, José Fernando; Ghezzi, Diego; Antognazza, Maria Rosa; Colombo, Elisabetta; Mete, Maurizio; Feyen, Paul; Desii, Andrea; Buschiazzo, Ambra; Di Paolo, Mattia; Di Marco, Stefano; Ticconi, Flavia (June 2017). "A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness". Nature Materials. 16 (6): 681–689. Bibcode:2017NatMa..16..681M. doi:10.1038/nmat4874. ISSN 1476-1122. PMC 5446789. PMID 28250420.
- ↑ Cuttaz, Estelle; Goding, Josef; Vallejo-Giraldo, Catalina; Aregueta-Robles, Ulises; Lovell, Nigel; Ghezzi, Diego; Green, Rylie A. (2019). "Conductive elastomer composites for fully polymeric, flexible bioelectronics". Biomaterials Science. 7 (4): 1372–1385. doi:10.1039/C8BM01235K. hdl:10044/1/83768. ISSN 2047-4830. PMID 30672514.
- ↑ Airaghi Leccardi, Marta Jole Ildelfonsa; Chenais, Naïg Aurelia Ludmilla; Ferlauto, Laura; Kawecki, Maciej; Zollinger, Elodie Geneviève; Ghezzi, Diego (December 2020). "Photovoltaic organic interface for neuronal stimulation in the near-infrared". Communications Materials. 1 (1): 21. Bibcode:2020CoMat...1...21A. doi:10.1038/s43246-020-0023-4. ISSN 2662-4443. Unknown parameter
|s2cid=ignored (help) - ↑ Ghezzi, Diego; Antognazza, Maria Rosa; Maccarone, Rita; Bellani, Sebastiano; Lanzarini, Erica; Martino, Nicola; Mete, Maurizio; Pertile, Grazia; Bisti, Silvia; Lanzani, Guglielmo; Benfenati, Fabio (May 2013). "A polymer optoelectronic interface restores light sensitivity in blind rat retinas". Nature Photonics. 7 (5): 400–406. Bibcode:2013NaPho...7..400G. doi:10.1038/nphoton.2013.34. ISSN 1749-4885. PMC 4855023. PMID 27158258.
- ↑ Airaghi Leccardi, Marta J.I.; Ghezzi, Diego (June 2020). "Organic electronics for neuroprosthetics". Healthcare Technology Letters. 7 (3): 52–57. doi:10.1049/htl.2019.0108. ISSN 2053-3713.
- ↑ Ferlauto, Laura; Airaghi Leccardi, Marta Jole Ildelfonsa; Chenais, Naïg Aurelia Ludmilla; Gilliéron, Samuel Charles Antoine; Vagni, Paola; Bevilacqua, Michele; Wolfensberger, Thomas J.; Sivula, Kevin; Ghezzi, Diego (December 2018). "Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis". Nature Communications. 9 (1): 992. Bibcode:2018NatCo...9..992F. doi:10.1038/s41467-018-03386-7. ISSN 2041-1723. PMC 5843635. PMID 29520006.
- ↑ Chenais, Naïg A. L.; Airaghi Leccardi, Marta J. I.; Ghezzi, Diego (2019-06-07). "Photovoltaic stimulation efficiently evokes network-mediated activity of retinal ganglion cells". bioRxiv: 652404. doi:10.1101/652404. Unknown parameter
|s2cid=ignored (help) - ↑ Gaillet, Vivien; Cutrone, Annarita; Artoni, Fiorenzo; Vagni, Paola; Mega Pratiwi, Ariastity; Romero, Sandra Alejandra; Lipucci Di Paola, Dario; Micera, Silvestro; Ghezzi, Diego (February 2020). "Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve". Nature Biomedical Engineering. 4 (2): 181–194. doi:10.1038/s41551-019-0446-8. ISSN 2157-846X. PMID 31427779. Unknown parameter
|s2cid=ignored (help) - ↑ Gaillet, Vivien; Cutrone, Annarita; Vagni, Paola; Artoni, Fiorenzo; Pinto, Sandra Alejandra Romero; Di Paola, Dario Lipucci; Micera, Silvestro; Ghezzi, Diego (2018-05-07). "Optic nerve intraneural stimulation allows selective visual cortex activation". bioRxiv: 311035. doi:10.1101/311035. Unknown parameter
|s2cid=ignored (help) - ↑ "Durchbruch in der Augenmedizin – Wie ein Blinder wieder sehen lernt". Der Bund (in Deutsch). Retrieved 2021-07-14.
- ↑ "Un micro-robot de l'EPFL pile-poil pour explorer le cerveau". www.heidi.news (in français). Retrieved 2021-02-26.
- ↑ "L'intérieur des vaisseaux sanguins accessible grâce à un fil". Le Matin (in français). 2020-12-22. ISSN 1018-3736. Retrieved 2021-02-26.
- ↑ "Connecting the dots to artificially restore vision". Physics World. 2021-04-08. Retrieved 2021-07-14.
- ↑ "First endovascular technology to explore capillaries". Tech Explorist. 2020-12-23. Retrieved 2021-02-26.
- ↑ "Intraneural electrode stimulates light sensation for the blind". The Engineer. 2019-08-20. Retrieved 2021-02-26.
- ↑ "Blind people may 'see' with optic nerve stimulation". The Week. Retrieved 2021-02-26.
- ↑ "L'EPFL développe un implant rétinien pour lutter contre la cécité". rts.ch (in français). 2018-03-08. Retrieved 2021-02-26.
- ↑ "Lithium restores cognitive function in Down syndrome mice". ScienceDaily. Retrieved 2021-02-26.
- ↑ "Vedere senza occhi si può, stimolando il nervo ottico". www.ilmessaggero.it (in italiano). Retrieved 2021-02-26.
- ↑ Ärzteblatt, Deutscher Ärzteverlag GmbH, Redaktion Deutsches (2019-08-20). "Optische Nervenstimulation: Kaninchen nehmen Licht ohne Augen wahr". Deutsches Ärzteblatt (in Deutsch). Retrieved 2021-02-26. Unknown parameter
|url-status=ignored (help) - ↑ "Neuroprothese: Wie Blinde wieder sehen könnten - derStandard.at". DER STANDARD (in Deutsch). Retrieved 2021-02-26.
- ↑ "Article list page". GOAP. Retrieved 2021-02-26.
- ↑ "PLOS ONE: accelerating the publication of peer-reviewed science". journals.plos.org. Retrieved 2021-02-26.
- ↑ "Editors | Scientific Reports". www.nature.com. Retrieved 2021-02-26.
- ↑ "Dreiländertagung" (PDF). VDE. Unknown parameter
|url-status=ignored (help)
External links[edit]
- Diego Ghezzi publications indexed by Google Scholar
- Medtronic Chair in Neuroengineering
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