E. James Petersson
| E. James Petersson | |
|---|---|
 EJamesPeterssonHeadshot.jpg | |
| Born | January 14, 1977 |
| 🏳️ Nationality | American |
| 🎓 Alma mater | Dartmouth College (A.B.), California Institute of Technology (Ph.D.) |
| 💼 Occupation | |
E. James Petersson (born January 14, 1977) is an American chemist and professor at the University of Pennsylvania. He holds appointments in the Department of Chemistry and the Department of Biochemistry and Molecular Biophysics in the Perelman School of Medicine.[1]
Education and career
Petersson earned his A.B. in Chemistry from Dartmouth College in 1998 and his Ph.D. in Chemistry from the California Institute of Technology in 2005 under the supervision of Dennis A. Dougherty.[2] He then completed postdoctoral training with Alanna Schepartz at Yale University. Petersson joined the faculty at the University of Pennsylvania in 2008, with a secondary appointment in Biochemistry and Molecular Biophysics beginning in 2018.[3]
Research
Petersson’s research integrates organic synthesis, molecular biology, physical chemistry, and computational tools to study protein dynamics, misfolding, and communication in biological systems.[4] His laboratory develops novel chromophores and incorporates them into proteins using unnatural amino acid mutagenesis and protein ligation to visualize protein behavior in vitro and in living cells.
Applications of his research include:
- Investigating protein folding, amyloid aggregation, and misfolding in neurodegenerative diseases such as Parkinson’s and Alzheimer’s
- Designing fluorescent, genetically encoded reporters for studying protein dynamics
- Developing radiotracers to improve diagnostic imaging of Parkinson’s disease and related disorders[5]
Honors and awards
Petersson’s work has been recognized with several awards, including:[2]
- Searle Scholar
- NSF CAREER Award
- Sloan Research Fellowship
- Journal of Physical Organic Chemistry Early Excellence Award
Selected publications
- “Fluorescence spectroscopy reveals N-terminal order in fibrillar forms of α-synuclein” (2018)[1]
- “A cryptophane-based ‘turn-on’ 129Xe NMR biosensor for monitoring calmodulin” (2017)[1]
- “Multicolor protein FRET with tryptophan” (2017)[1]
- “Effect of nascent peptide steric bulk on elongation kinetics” (2017)[1]
Professional affiliations
Petersson is a member of several scientific societies, including the American Chemical Society, the Biophysical Society, the Protein Society, and the Society for Biological Engineering.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "E. James Petersson". University of Pennsylvania. Retrieved 2025-08-27.
- ↑ 2.0 2.1 2.2 "Curriculum Vitae: E. James Petersson". Retrieved 2025-08-27.
- ↑ "Meet the Authors: Jun Chenoweth and Petersson". Royal Society of Chemistry. Retrieved 2025-08-27.
- ↑ "E. James Petersson". Case Western Reserve University. Retrieved 2025-08-27.
- ↑ "Penn Medicine researchers to advance imaging of Parkinson's diseases". Penn Medicine News. Retrieved 2025-08-27.
External links
References
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