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Edgardo D. Carosella

From EverybodyWiki Bios & Wiki



Edgardo D. Carosella was born in Buenos Aires on April 9, 1951, and is a French immunologist.

Edgardo D Carosella, Member of the French Academy of sciences

École Normale Supérieure de Professeurs Mariano Acosta (Argentina, 1968). MD, Faculty of Medicine, University of El Salvador S.J. (Argentina, 1975). Research Director at the French Atomic Energy Commission and Head of the Hemato-immunology Research Department at Saint-Louis Hospital (Paris) since 1995. Founder and Vice-President of the Jean Dausset-CEPH Foundation (Centre d'Étude du Polymorphisme Humain):.[1] since 1997.

Scientific work[edit]

Carosella began his scientific career in 1972 at the Institute of Hematological Research of the National Academy of Medicine in Buenos Aires (Argentina). His research focuses on the regulation of lymphocyte function in lymphoma patients and cellular immunity in leprosy patients. It establishes for the first time a perfect correlation between T-cell activity and the different forms of leprosy (undetermined lepromatous and tuberculoid), proving its fundamental role in undifferentiated leprosy and its evolution towards the lepromatous or tuberculoid form. In addition, after inoculating armadillos with Hansen's bacillus from a patient, he described for the first time, together with a Canadian team (E. Storrs et al.), the reproduction of the leprosy in armadillos (until then this inoculation, in all animals tested, did not reproduce the disease). He was the first to study the humoral and cellular immunological system in three different species of armadillos, very primitive in the zoological scale (Chaetophractus villosus, Dasypus hybridus, Septecintus and Zaedus pichei), which allowed him to standardize and recommend the most appropriate species for obtaining leprosy in animals (Septecintus and Zaedus). Since then, this species has been used both as a reproductive model of the disease and for obtaining leprosy.

In 1974, through the immunological study of patients with Hodgkin's and non-Hodgkin lymphoma, E. D. Carosella showed in these patients the absence of a cutaneous reaction to tuberculin associated with a decrease in the number of T lymphocytes and their reactivity to the same antigen. The lowest rates corresponded to the cytological types of the most severe prognoses for Hodgkin disease. They were also correlated with the clinical status of the patients and the degree of spread of the disease.

In 1976, invited by Professor Jean Bernard, he joined Professor Jean Dausset's team at the University Institute of Hematology (IUH)[2] at Saint-Louis Hospital. It applies to the study of HLA Human Leukocyte Antigen, their role in cellular immunity and allogeneic transplantation. The objective is to highlight the genetic control of the allogeneic proliferative response, the existence of suppressor and cytotoxic lymphocytes, and the factors mediating this activity. Until then, genetic control of alloproliferation had been attributed to the HLA-A, -B, -C antigens of the HLA complex.

But the study carried out by E.D. Carosella on informative families modified this concept and demonstrated the existence of an autonomous system similar to the HLA-B series located at 1% recombination of the latter and responsible for allogeneic proliferation. This system would later be called the HLA-D region, which suggests the existence of several locus. During the allogeneic response, he also observed the production of immune memory cells capable of rapidly proliferating when re-stimulated by cells used for primary immunization, which is controlled by a new type of antigen called HLA-DR. It was also during this reaction that he saw the differentiation of a suppressive T lymphocyte population capable of inhibiting the allogeneic response. These cells were able to secrete a suppressive factor that inhibited this response in a non-specific manner. He later demonstrated that this inhibition was due to the HLA-G molecule.

It is through his work on the HLA-G molecule that E.D. Carosella makes a discovery that has totally changed the understanding of fetal-maternal tolerance. For the first time, it is possible to answer decisively the question of why a mother does not reject her semi-allogenetic fetus (since it carries paternal antigens). He made the first ex vivo demonstration of the protective role of the HLA-G molecule, present on the surface of cytotrophoblast cells, against lysis exerted by NK cells infiltrating the uterine decidual, both under semi-allogenetic (cytotrophoblast and NK cells from the same mother) and allogenic (uterine and cytotrophoblast NK cells from different mothers) conditions. The blocking of this protein by specific anti-HLA-G antibodies triggers significant cytotoxicity to these fetal cells. In this way, the fetus is protected from rejection reactions mediated by maternal T cells and NK lymphocytes. In addition, he demonstrated that the HLA-G molecule is an inhibitor of immunocompetent cells: NK, T, antigen presenting cells (APC) and Ac. He described three major clinical consequences of the expression of this protein: a) in the context of pregnancy, HLA-G is the prerequisite for embryonic implantation; b) in organ transplantation, it induces a lack of rejection; c) in the tumor context, its expression has a negative functional impact on the anti-tumor response.

Awards and prizes[edit]

  •    Honorary Professor of the Universidad del Salvador, Buenos Aires (Argentina), 1997
  •    Official host of the Autoridad Regulatoria Nuclear (Argentina), 1999
  •    Corresponding elected member of the French Academy of sciences of the Institut de France, 1999
  •    Elected member of the European Academy of Sciences[3], Brussels (Belgium), 2002
  •    International Scientist of the Year, International Biographical Centre, Cambridge (UK), 2003
  •    Doctor Honoris Causa of the University of El Salvador (Argentina), 2006
  •    Foreign elected member of the Real Academia de Medicina y Cirugia de Murcia, Instituto de España, 2014
  •    Foreign elected member of the Real Academia de Medicina y Cirugia de Sevilla, Instituto de España, 2015
  •    Foreign elected member of the Real Academia de Córdoba de Ciencas, Bellas Letras y Nobles Artes, Instituto de España, 2016.
  •    Juan M. Fernandes Prize: Exploracion de la immunidad mediada por celulas en pacientes de lepra (Federacion del patronato del enfermo de lepra de la Republica Argentina), Buenos Aires (Argentina), 1977
  •    Price of the European Group for Blood and Marrow Transplantation: In situ rt-pcr: expression of cd34 gene in individual cells, Davos (Switzerland), 1995
  •    European Prize of the Fundacion Balear Transplant: Functional role of pecam-1/cd31 molecule expressed on human blood progenitors, Balearic Islands (Spain), 1995
  •    International Society of Experimental Hematology Award: Evidence for the presence of the alternatively splicedHLA-G mRNA forms in human mononuclear cells from peripheral blood and umbilical cord blood, Düsseldorf (Germany), 1995
  •    Merit Award of 13th International Congress of Histocompatibility and Immunogenetics, Seattle Washington (United States), 2002
  •    2009 Blaise Pascal Medal in Medicine, European Academy of Sciences, The Blaise Pascal Medal for Science and Technology, Bologna (Italy), 2009.

Decorations[edit]

Bibliography[edit]

Major scientific articles[edit]

  • Carosella E.D., Dausset J., Kirszenbaum M. « HLA-G Revisited » Immunology Today 1996;17: 407-9.
  • Carosella E.D., Dausset J., Rouas-Freiss N. « Transplacental Transmission of Natural-Killer-Cell Lymphoma » The New England Journal of Medecine, 1999;25:1937
  • Carosella E.D., Rouas-Freiss N., Paul P., Dausset J., HLA-G: A Tolerance Molecule from the Major Histocompatibility Complex [archive], Immunology Today, 20: 60-62, 1999
  • Carosella E.D., Paul P., Moreau Ph., Rouas-Freiss N., HLA-G and –E: Fundamental and Physiopathological Aspects [archive], Immunology Today, 21: 532-534, 2000
  • Aractingi S., Uzan S., Dausset J., Carosella E.D., Microchimerism in Human Diseases [archive], Immunology Today, 21: 116-118, 2000
  • Carosella E.D., Moreau P., Aractingi S., Rouas-Freiss N., HLA-G: A Shield against Inflammatory Aggression [archive], Trends in Immunology, 22: 553-555, 2001
  • Carosella E.D., Pradeu T., Transplantation and Identity: a Dangerous Split? [archive] The Lancet, 368: 183-184, 2006
  • Carosella E.D., Favier B., Rouas-Freiss N., Moreau P., LeMaoult J., Beyond the Increasing Complexity of the Immunomodulatory HLA-G Molecule [archive], Blood, 111: 4862-4870, 2008
  • Carosella E.D., Moreau P., LeMaoult J., Rouas-Freiss N., HLA-G: From Biology to Clinical Benefits [archive], Trends in Immunology, 29: 125-132, 2008
  • Carosella E.D., Favier B., Rouas-Freiss N., Moreau Ph., LeMaoult J., "Beyond the Increasing Complexity of the Immunomodulatory HLA-G Molecule", Blood 2008; 111 : 4862-4870.
  • Agaugué S., Carosella E.D., "Update on HLA-G in Tumor Cell Immune Escape", Trends in Cancer Research 2008; 4: 79-92.
  • Carosella E.D., "Jean Dausset 1916-2009", Nature Immunology 2009; 10: 797.
  • Carosella E.D., Lemaoult J., "HLA-G: a Look Back, a Look Forward",[null Cell. Mol. Life Sci.] 2011 ; 68: 337-340.
  • Carosella E.D., Ploussard G., LeMaoult J., Desgrandchamps F., "A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G", European Urology, 2015; 68: 267-279.
  • Carosella E.D., Rouas-Freiss N., Tronik-Le Roux D., Moreau P., LeMaoult J., "HLA-G: an Immune Checkpoint Molecule", Advances in Immunology, 2015; 127: 33-144.

Main Books[edit]

  • Immunologia de las enfermedades infecciosas avec A.E. Bachmann et coll., Buenos Aires Arte, 1978[4]
  • Rôle de la molécule HLA-G dans la tolérance fœto-maternelle et l’implantation embryonnaire avec N. Rouas-Freiss, Masson, 2000
  • L’Identité ? Soi et non-soi, individu et personne avec T. Pradeu, B. Saint-Sernin et C. Debru, Paris, PUF, 2006[5]
  • L’identité changeante de l’individu - La constante construction du Soi avec B. Saint-Sernin, Ph. Capelle et S.E. M. Sánchez Sorondo, Paris, L’Harmattan, 2008[6]
  • L'identité, la part de l’autre - Immunologie et philosophie avec T. Pradeu, Paris, Odile Jacob, 2010[7]
  • Nature et Artifice - l’homme face à l’évolution de sa propre essence, sous la direction de Edgardo D. Carosella, Paris, Hermann, 2014[8]
  • Elogio a la diferencia y libertad del yo, Ed. Real Academia de Córdoba, 6 octobre 2016.
  • Le sens de la vie, sous la direction de Edgardo D. Carosella, Paris, Hermann, 2017[9]

Références[edit]

Among 314 articles published between 1980 and 2017 in international peer-reviewed scientific journals[10] [11]

  • Sasportes M., Wollman E., Cohen D., Carosella E., Bensussan A., Fradelizi D., Dausset J. « Suppression of the Human Allogenetic Response in vitro with Primed Lymphocytes and Suppressive Supernates » J Exp Med. 1980;152: 270s-283s. PMID 6447744 [archive]
  • Carosella E.D., Dunlap N.E., Tilden A.B., Cooper M. « Effect of IL1 and IL2 on Differentiation of Human B Lymphocytes Induced by Fc Fragment of Human IgG » FASEB 1988;2:1669 (7974)
  • Carosella E.D., Dunlap N.E., Tilden A.B. « Effect of Fc Fragment on IL1 beta and IFN gamma Production by Human Mononuclear Cells » FASEB 1989;3:500 (1592)
  • Debré M., Bonnet M.C., Fridman W.H., Carosella E., Philippe N., Reinert P., Vilmer E., Kaplan C., Teillaud J., Griscelli C. « Infusion of Fcy Fragments for Treatment of Children with Acute Immune Thrombocytopenic Purpura » Lancet 1993;342:945-9. PMID 8105212 [archive]
  • Socié G., Gluckman E., Carosella E., Brossard Y., Lafon C., Kirszenbaum M., Brison O. « Search for Maternal Cells in Human Umbilical Cord Blood by Polymerase Chain Reaction Amplification of Two Minisatellite Sequences » Blood 1994;83:340-4. PMID 8286734 [archive]
  • Kirszenbaum M., Moreau P., Gluckman E., Dausset J., Carosella E. « An Alternatively Spliced Form of HLA-G mRNA in Human Trophoblasts and Evidence for the Presence of HLA-G Transcript in Adult Lymphocytes » Proc Natl Acad Sci. USA 1994;91:4209-13. PMID 8183892 [archive]
  • Bensussan A., Gluckman E., El Marsafy S., Schiavon V., Mansur I-G., Dausset J., Boumsell L. and Carosella E. « BY55 mAb Delineates within Human Cord blood and Bone Marrow Lymphocytes Distinct Cell Subsets Mediating Cytotoxic Activity » Proc Natl Acad Sci. USA 1994;91:9136-40. PMID 8090781 [archive]
  • Griscelli-Bennaceur A., Gluckman E., Scrobohaci M.L., Jonveaux P., Vu T., Bazarbachi A., Carosella E D., Sigaux F., Socié G. « Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria: Search for a Pathogenetic Link » Blood 1995;85:1354-63. PMID 7858265 [archive]
  • Bensussan A., Mansur I.G., Mallet V., Rodriguez A.M., Girr M., Weiss E.H., Brem G., Boumsell L., Gluckman E., Dausset J., Carosella E.D., Le Bouteiller P. « Detection of Membrane-Bound HLA-G Translated Products with a Specific Monoclonal Antibody » Proc Natl Acad Sci. USA 1995;92:10292-6. PMID 7479770 [archive]
  • Rouas-Freiss N., Marchal R.E., Kirszenbaum M., Dausset J., Carosella E.D. « The alpha1 Domain of HLA-G1 and HLA-G2 Inhibits Cytotoxicity Induced by Natural Killer Cells: Is HLA-G the Public Ligand for Natural Killer Cell Inhibitory Receptors? » Proc Natl Acad Sci. USA 1997;94:5249-54. PMID 9144223 [archive]
  • Rouas-Freiss N., Gonçalves R.M., Menier C., Dausset J., Carosella E.D. « Direct Evidence to Support the Role of HLA-G in Protecting the Fetus from Maternal Uterine Natural Killer Cytolysis » Proc Natl Acad Sci. USA 1997;94:11520-5. PMID 9326642 [archive]
  • Paul P., Rouas-Freiss N., Khalil-Daher I., Moreau P., Riteau B., Le Gal F.A. Avril M.F., Dausset J., Guillet J.G., Carosella E.D., HLA-G Expression in Melanoma: a Way for Tumor Cells to Escape from Immunosurveillance [archive], Proc. Natl. Acad. Sci. USA, 95(8): 4510-4515, 1998
  • Aractingi S., Dausset J., Carosella E.D., Chimerism in Scleroderma [archive], The Lancet, 351: 1886, 1998
  • Aractingi S., Berkane N., Bertheau Ph., Le Goué C., Dausset J., Uzan S., Carosella E.D., Fetal DNA in Skin of Polymorphic Eruptions of Pregnancy [archive], The Lancet, 352: 1898-1901, 1998
  • Paul P., Cabestré F.A., Le Gal F.A., Khalil-Daher I., Le Danff C., Schmid M., Mercier S., Avril M.F., Dausset J., Guillet J.G., Carosella E.D., Heterogeneity of HLA-G Gene Transcription and Protein Expression in Malignant Melanoma Biopsies [archive], Cancer Research, 59: 1954-1960, 1999
  • Lila N., Carpentier A. , Amrein C., Khalil-Daher I., Dausset J., Carosella E.D., Implication of HLA-G Molecule in Heart-Graft Acceptance [archive], The Lancet, 355: 2138, 2000
  • Ibrahim E.C., Guerra N., Lacombe M.J., Angevin E., Chouaib S., Carosella E.D., Caignard A., Paul P., Tumor-Specific Up-Regulation of the Nonclassical Class I HLA-G Antigen Expression in Renal Carcinoma [archive], Cancer Research, 61: 6838-6845, 2001
  • Lila N., Rouas-Freiss N., Dausset J., Carpentier A., Carosella E.D., Soluble HLA-G Protein Secreted by Allo-specific CD4+ T Cells Suppresses the Allo-Proliferative Response: A CD4+ T Cell Regulatory Mechanism [archive], Proc. Natl. Acad. Sci. USA, 98: 12150-12155, 2001
  • Lila N., Amrein C., Guillemain R., Chevalier P., Latremouille C., Fabiani J.N., Dausset J., Carosella E.D., Carpentier A., Human Leukocyte Antigen-G Expression after Heart Transplantation is Associated with a Reduced Incidence of Rejection [archive], Circulation, 105: 1949-1954, 2002
  • Moreau Ph., Mouillot G., Rousseau Ph., Marcou C., Dausset J., Carosella E.D., HLA-G Gene Repression is Reversed by Demethylation [archive], Proc. Natl. Acad. Sci. USA, 100: 1191-1196, 2003
  • LeMaoult J., Krawice-Radanne I., Dausset J., Carosella E.D., HLA-G1-Expressing Antigen-Presenting Cells Induce Immunosuppressive CD4+ T Cells [archive], Proc. Natl. Acad. Sci. USA, 101: 7064-7069, 2004
  • Menier C., Rabreau M., Challier J.C., Le Discorde M., Carosella E.D., Rouas-Freiss N., Erythroblasts Secrete the Nonclassical HLA-G Molecule from Primitive to definitive Hematopoiesis [archive], Blood, 104: 3153-3160, 2004
  • LeMaoult J., Zafaranloo K., Le Danff C., Carosella E.D., HLA-G Up-Regulates ILT2, ILT3, ILT4 and KIR2DL4 in Antigen Presenting Cells, NK Cells and T Cells [archive], The FASEB, 19: 662-664, 2005
  • Aractingi S., Kanitakis J., Euvrard S., Le Danff C., Peguillet I., Khosrotehrani K., Lantz O., Carosella E.D., Skin Carcinoma Arising from Donor Cells in a Kidney Transplant Recipient [archive], Cancer Research, 65: 1755-1760, 2005
  • Nguyen S., Dhedin N., Vernant J-P., Kuents M., Al Jiakli A., Rouas Freiss N., Carosella E. D., Boudifa A., Debré P., Vieillard V., NK Cell Reconstitution after Haploidentical Hematopoietic Stem-Cell Transplantations: Immaturity of NK Cells and Inhibitory Effect of NKG2A Override GvL Effect [archive], Blood, 105: 4135-4142, 2005
  • Rouas-Freiss N., Moreau P., Ferrone S., Carosella E.D., HLA-G Proteins in Cancer: Do They Provide Tumor Cells with an Escape Mechanism? [archive] Cancer Research, 65: 10139-10144, 2005
  • Pradeu T., Carosella E.D., On the Definition of a Criterion of Immunogenicity [archive], Proc. Natl. Acad. Sci. USA, 103: 17858-17861, 2006
  • LeMaoult J., Caumartin J., Daouya M., Favier B., LeRond S., Gonzales A., Carosella E.D., Immune Regulation by Pretenders: Cell-to-Cell Transfers of HLA-G Make Effector T Cells Act as Regulatory Cells [archive], Blood, 109: 2040-2048, 2007
  • Naji A., Le Rond S., Durrbach A., Krawice-Radanne I., Creput C., Daouya M., Caumartin J., LeMaoult J., Carosella E.D., Rouas-Freiss N., CD3+CD4low and CD3+CD8low are Induced by HLA-G: Novel Human Peripheral Blood Suppressor T-cell Subsets Involved in Transplant Acceptance [archive], Blood, 110: 3936-48, 2007
  • Selmani Z., Naji A., Zidi I., Favier B., Gaiffe E., Obert L., Borg C., Saas P., Tiberghien P., Rouas-Freiss N., Carosella E.D., Deschaseaux F., Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stems Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells [archive], Stem Cells, 26: 212-222, 2008
  • Liang S., Ristich V., Arase H., Dausset J., Carosella E.D., Horuzsko A., Modulation of Dendritic Cell Differentiation by HLA-G and ILT4 Requires the IL-6--STAT3 Signaling Pathway [archive], Proc. Natl. Acad. Sci. USA, 105: 8357-8362, 2008
  • Moreau P., Flajollet S., Carosella E.D., Non-Classical Transcriptional Regulation of HLA-G: an Update [archive], J. Cell. Mol. Med., 13: 2973-2989, 2009
  • Favier B., LeMaoult J., Lesport E., Carosella E.D., ILT2/HLA-G Interaction Impairs NK-Cell Functions through the Inhibition of the Late but not the Early Events of the NK-Cell Activating Synapse [archive], The FASEB, 24:689-699, 2010
  • HoWangYin K.Y., Alegre E., Daouya M., Favier B., Carosella E.D., LeMaoult J., Different Functional Outcomes of Intercellular Membrane Transfers to Monocytes and T Cells [archive], Cell. Mol. Life Sci., 67: 1133-1145, 2010
  • Alegre E., HoWangYin K-Y, Favier B., Baudhuin J., Lesport E., Daouya M., González Á., Carosella E.D., LeMaoult J., Membrane Redistributions through Multi-Intercellular Exchanges and Serial Trogocytosis [archive], Cell Res., 20: 1239-1251, 2010
  • Carosella E.D., Gregori S., Rouas-Freiss N., LeMaoult J., Menier C., Favier B., The Role of HLA-G in Immunity and Hematopoiesis [archive], Cell. Mol. Life Sci., 68: 353-368, 2011
  • HoWangYin K-Y, Caumartin J., Favier B., Daouya M., Yaghi L., Carosella E.D., LeMaoult J., Proper Regrafting of Ig-Like Transcript 2 after Trogocytosis Allows a Functional Cell-Cell Transfer of Sensitivity [archive], J. Immunol., 186: 2210-2218, 2011
  • Verloes A., Van de Velde H., LeMaoult J., Mateizel I., Cauffman G., Horn P.A., Carosella E.D., Devroey P., De Waele M., Rebmann V., Vercammen M., HLA-G Expression in Human Embryonic Stem Cells and Preimplantation Embryos [archive], J. Immunol., 186: 2663-2671, 2011
  • Agaugué S., Carosella E.D., Rouas-Freiss N., Role of HLA-G in Tumor Escape through Expansion of Myeloid-Derived Suppressor Cells and Cytokinic Balance in favor of Th2 vs Th1/Th17 [archive], Blood, 117: 7021-7031, 2011
  • Carosella E.D., Gregori S., LeMaoult J., The Tolerogenic Interplay(s) Among HLA-G, Myeloid APCs, and Regulatory Cells [archive], Blood 2011; 118: 6499-6505
  • Naji A., Menier C., Maki G., Carosella E.D., Rouas-Freiss N., Neoplastic B-Cell Growth is Impaired by HLA-G/ILT2 Interaction, Leukemia 2012;26:1889-92.
  • LeMaoult J., Daouya M., Wu J., Loustau M., Horuzsko A., Carosella E.D., Synthetic HLA-G Proteins for Therapeutic Use in Transplantation., FASEB, 2013; 27: 3643-3651.
  • Naji A., Rouas-Freiss N., Durrbach A., Carosella E.D., Sensébé L., Deschaseaux F., Concise Review: Combining Human Leukocyte Antigen G and Mesenchymal Stem Cells for Immunosuppressant Biotherapy, Stem Cells, 2013; 31: 2296-2303.
  • Naji A., Menier C., Morandi F., Agaugué S., Maki G., Ferretti E., Bruel S., Pistoia V., Carosella E.D., Rouas-Freiss N., Binding of HLA-G to ITIM-Bearing Ig-like Transcript 2 Receptor Suppresses B Cell Responses, Journal of Immunology, 2014; 192:1536-1546.
  • Leibler C., Matignon M., Pilon C., Montespan F., Bigot J., Lang P., Carosella E.D., Cohen J., Rouas-Freiss N., Grimbert P. and Menier C., Kidney Transplant Recipients Treated with Belatacept Exhibit Increased Naïve and Transitional B Cells, American Journal of Transplantation, 2014; 14: 1173-1182.
  • Brugière O., Thabut G., Krawice-Radanne I, Rizzo R., Dauriat G., Danel C., Suberbielle C., Mal H., Stern M., Schilte C., Pretolani M., Carosella E. D. and Rouas-Freiss N., Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study, American Journal of Transplantation, 2015; 15:461-471.
  • Wu D., Kuiaste I., Moreau P., Carosella ED., Yotnda P, Rescuing Lymphocytes from HLA-G Immunosuppressive Effects mediated by the Tumor Microenvironment, Oncotarget, 2015; 6: 37385-37397.
  • Yaghi L.; Poras I.; Simoes R.T.; Donadi E.A; Tost J.; Daunay A.; Sgorla B.; Carosella E.D.; Moreau P., Hypoxia inducible Factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through Hypoxia response element located in exon 2., Oncotarget, 2016, doi: 10.18632/oncotarget.11628.



This article "Edgardo D. Carosella" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Edgardo D. Carosella. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.

  1. ↑ Fondation Jean Dausset-CEPH (Centre d’Étude du Polymorphisme Humain)
  2. ↑ Site internet de l'Institut universitaire d’hématologie (IUH).
  3. ↑ European Academy of Sciences
  4. ↑ "Inmunologia de Las Enfermedades Infecciosas". Unknown parameter |url-status= ignored (help)
  5. ↑ "Soi et non-soi individu et personne". Unknown parameter |url-status= ignored (help)
  6. ↑ "L'identité changeant de l'individu". Unknown parameter |url-status= ignored (help)
  7. ↑ "L'identité, la part de l'autre". Unknown parameter |url-status= ignored (help)
  8. ↑ "Nature et artifice". Unknown parameter |url-status= ignored (help)
  9. ↑ "Le sens de la vie". Unknown parameter |url-status= ignored (help)
  10. ↑ https://www.ncbi.nlm.nih.gov/pubmed?term=Carosella%20ED[Author]&cauthor=true&cauthor_uid=21482709
  11. ↑ Bibliographie indexée par Google Scholar

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