Evan Z. Macosko
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Evan Z. Macosko is a neuroscientist and psychiatrist whose group develops and applies single-cell and spatial genomics methods to study the brain. He is a core institute member and the Edward Scolnick Professor at the Broad Institute of MIT and Harvard, and an associate professor in the Departments of Psychiatry and Neurobiology at Harvard Medical School (HMS).[1] Macosko co-developed Drop-Seq for high-throughput single-cell RNA sequencing[2] and later co-developed Slide-seq, a spatial transcriptomics method published in Science in 2019.[3] His work has been profiled by independent outlets including Nature and MIT Technology Review.[4][5]
Early life and education
Macosko earned an A.B. in chemistry from Harvard College, an M.D. from Weill Cornell Medical College, and a Ph.D. from The Rockefeller University, where he worked with Cori Bargmann.[1][6] He completed psychiatry residency training at McLean Hospital and Massachusetts General Hospital (MGH).[1]
Career
As a postdoctoral researcher in Steve McCarroll's laboratory at HMS, Macosko co-developed Drop-seq, a droplet-based method that enabled low-cost profiling of thousands of single cells in parallel.[2][7] He later established his own laboratory at the Broad Institute and HMS, where his group co-developed Slide-seq for spatially resolved transcriptomics at near-cellular resolution.[3] The Slide-seq work and subsequent advances have been discussed in independent coverage of the spatial transcriptomics field.[4]
Macosko is a core institute member at the Broad Institute and co-director of the Center for Human Brain Cell Variation. He holds the Edward Scolnick Professorship at the Broad and is an associate professor at HMS.[1] He also practices as an attending psychiatrist at MGH.[8]
Research
Macosko's research focuses on inventing and applying genomics technologies to map cell types and states in the nervous system and to study the mechanisms of neuropsychiatric and neurodegenerative disease.[1] He has co-authored reviews on spatial transcriptomics that synthesize developments across capture-based and imaging-based approaches.[9]
Awards and honors
- Innovators Under 35 (Global), MIT Technology Review (2016).[5]
- Pew Scholar in the Biomedical Sciences (2020).[10]
- Pershing Square MIND Prize (2023 cohort).[11]
Selected publications
- Macosko, Evan Z.; Basu, Anindita; Satija, Rahul; Nemesh, James; Shekhar, Karthik; Goldman, Melissa; Tirosh, Itay; Bakkour, Sabrina; Katz, Yosef; et al. (21 May 2015). "Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets". Cell. 161 (5): 1202–1214. doi:10.1016/j.cell.2015.05.002. PMID 26000488.
- Rodriques, Samuel G.; Stickels, Robert R.; Goeva, Aleksandrina; Martin, Carly A.; Murray, Evan; Vanderburg, Charles R.; Welch, Joshua; Chen, Linlin M.; Chen, Fei; Macosko, Evan Z. (29 March 2019). "Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution". Science. 363 (6434): 1463–1467. Bibcode:2019Sci...363.1463R. doi:10.1126/science.aaw1219. PMC 6927209 Check
|pmc=value (help). PMID 30923225. - Tian, Luyi; Chen, Fei; Macosko, Evan Z. (June 2023). "The expanding vistas of spatial transcriptomics". Nature Biotechnology. 41 (6): 773–782. doi:10.1038/s41587-022-01448-2. PMID 36192637 Check
|pmid=value (help).
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "Evan Macosko, M.D., Ph.D." Broad Institute. February 2025. Retrieved 18 October 2025.
- ↑ 2.0 2.1 "Beyond average". Harvard Medical School News. 21 May 2015. Retrieved 18 October 2025.
- ↑ 3.0 3.1 Rodriques, Samuel G.; Stickels, Robert R.; Goeva, Aleksandrina; Martin, Carly A.; Murray, Evan; Vanderburg, Charles R.; Welch, Joshua; Chen, Linlin M.; Chen, Fei; Macosko, Evan Z. (29 March 2019). "Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution". Science. 363 (6434): 1463–1467. Bibcode:2019Sci...363.1463R. doi:10.1126/science.aaw1219. PMC 6927209 Check
|pmc=value (help). PMID 30923225. - ↑ 4.0 4.1 Bishop, Donna (20 March 2019). "Companies seek slice of spatial imaging market". Nature. Retrieved 18 October 2025.
- ↑ 5.0 5.1 "Evan Macosko — Innovators Under 35 (2016)". MIT Technology Review. 2016. Retrieved 18 October 2025.
- ↑ "About Us — Macosko Lab". Macosko Lab. Retrieved 18 October 2025.
- ↑ Macosko, Evan Z.; Basu, Anindita; Satija, Rahul; Nemesh, James; Shekhar, Karthik; Goldman, Melissa; Tirosh, Itay; Bakkour, Sabrina; Katz, Yosef; et al. (21 May 2015). "Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets". Cell. 161 (5): 1202–1214. doi:10.1016/j.cell.2015.05.002. PMID 26000488.
- ↑ "Evan Macosko, M.D., Ph.D." Mass General Research Institute. Retrieved 18 October 2025.
- ↑ Tian, Luyi; Chen, Fei; Macosko, Evan Z. (June 2023). "The expanding vistas of spatial transcriptomics". Nature Biotechnology. 41 (6): 773–782. doi:10.1038/s41587-022-01448-2. PMID 36192637 Check
|pmid=value (help). - ↑ "Evan Macosko, M.D., Ph.D. — Pew Biomedical Scholars". The Pew Charitable Trusts. 2020. Retrieved 18 October 2025.
- ↑ "Evan Macosko, M.D., Ph.D. — MIND Prize Winner (2023)". Pershing Square Philanthropies. 2025. Retrieved 18 October 2025.
External links
- Official website
- "Evan Macosko — Broad Institute profile". Broad Institute. 14 September 2020.
- "Evan Macosko — Mass General profile". Mass General Research Institute.
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