Jan Liphardt
| Jan Liphardt | |
|---|---|
| File:Jan liphardt.jpgJan_liphardt.jpg | |
| Born | 1972 (age 53–54) |
| 🏳️ Citizenship | Germany |
| 💼 Occupation | |
| 🏅 Awards | |
| 🌐 Website | https://liphardtlab.stanford.edu |
Jan Liphardt (born 1972 in Germany) is a German biophysicist. His research primarily focuses on single molecule biophysics. As a postdoctoral fellow in the labs of Carlos Bustamante and Ignacio Tinoco Jr. in the physics department at University of California, Berkeley, he developed technologies that allowed single RNA molecules to grabbed and mechanically unfolded.[1] Subsequent work includes the development of "Plasmon Rulers"[2] (with Paul Alivisatos), the use of super-resolution imaging to understand the organization of microbial biofilms[3] (with Steven Chu), and the use of photo activation localization microscopy to characterize the organization of single transmembrane proteins[4] (with Eric Betzig). He is an associate professor of bioengineering at Stanford University. His research has been cited more than 15,000 times.[5]
Mechanical Manipulation of Single Nucleic Acids
In the original work performed in 2001,[1] single RNA hairpins were attached to long RNA/DNA 'handles' which were chemically coupled to beads held by optical tweezers. The RNA/DNA handles allow nanometer scale movements (and piconewton range forces) to be applied and measured. This basic tool geometry has been cited by more than 1100 papers covering RNA structure/function (reviewed in[6][7][8]), studies of thermodynamics of small perturbed systems (reviewed in[9][10]), and studies of molecular machines that act on RNA, such as RNA helicases[11] (reviewed in[12]). The original work (and followup studies) are used in life sciences and nanotechnology textbooks to illustrate the energetics and kinetics of nucleic acid folding.[13][14][15]
NCI PS-OC Program
In 2009, Liphardt became the principal investigator of one of 12 national physical science oncology centers,[16][17] which were intended to bring physical scientists to cancer research.[18][19]
Biden Cancer Moonshot
In 2016, as part of the Beau Biden Cancer Moonshot, he led a team of scientists and volunteers from a Bay Area social network[20] to build a system for cancer patients to share their healthcare data with teachers, researchers, and journalists.[21]
References
- ↑ 1.0 1.1 Liphardt J, Onoa B, Smith SB, Tinoco I, Bustamante C (2001). "Reversible unfolding of single RNA molecules by mechanical force". Science. 292 (5517): 733–7. Bibcode:2001Sci...292..733L. doi:10.1126/science.1058498. PMID 11326101. Unknown parameter
|s2cid=ignored (help)CS1 maint: Multiple names: authors list (link) - ↑ Sönnichsen C, Reinhard BM, Liphardt J, Alivisatos AP (2005). "A molecular ruler based on plasmon coupling of single gold and silver nanoparticles". Nat Biotechnol. 23 (6): 741–5. doi:10.1038/nbt1100. PMID 15908940. Unknown parameter
|s2cid=ignored (help)CS1 maint: Multiple names: authors list (link) - ↑ Berk V, Fong JC, Dempsey GT, Develioglu ON, Zhuang X, Liphardt J; et al. (2012). "Molecular architecture and assembly principles of Vibrio cholerae biofilms". Science. 337 (6091): 236–9. Bibcode:2012Sci...337..236B. doi:10.1126/science.1222981. PMC 3513368. PMID 22798614.CS1 maint: Multiple names: authors list (link)
- ↑ Greenfield D, McEvoy AL, Shroff H, Crooks GE, Wingreen NS, Betzig E; et al. (2009). "Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy". PLOS Biol. 7 (6): e1000137. doi:10.1371/journal.pbio.1000137. PMC 2691949. PMID 19547746.CS1 maint: Multiple names: authors list (link)
- ↑ "Liphardt Citations". Google Scholar. Retrieved 2023-12-27.
- ↑ Bustamante CJ, Chemla YR, Liu S, Wang MD (2021). "Optical tweezers in single-molecule biophysics". Nat Rev Methods Primers. 1. doi:10.1038/s43586-021-00021-6. PMC 8629167 Check
|pmc=value (help). PMID 34849486 Check|pmid=value (help). - ↑ Tinoco I, Chen G, Qu X (November 2010). "RNA reactions one molecule at a time". Cold Spring Harb Perspect Biol. 2 (11): a003624. doi:10.1101/cshperspect.a003624. PMC 2964187. PMID 20739416.
- ↑ Li PT, Vieregg J, Tinoco I (2008). "How RNA unfolds and refolds". Annu Rev Biochem. 77: 77–100. doi:10.1146/annurev.biochem.77.061206.174353. PMID 18518818.
- ↑ Rissone P, Ritort F (July 2022). "Nucleic Acid Thermodynamics Derived from Mechanical Unzipping Experiments". Life (Basel). 12 (7): 1089. Bibcode:2022Life...12.1089R. doi:10.3390/life12071089. PMC 9320087 Check
|pmc=value (help). PMID 35888177 Check|pmid=value (help). - ↑ Ritort F (August 2006). "Single-molecule experiments in biological physics: methods and applications". J Phys Condens Matter. 18 (32): R531–83. arXiv:cond-mat/0609378. doi:10.1088/0953-8984/18/32/R01. PMID 21690856.
- ↑ Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C (January 2006). "RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP". Nature. 439 (7072): 105–8. Bibcode:2006Natur.439..105D. doi:10.1038/nature04331. PMC 1560093. PMID 16397502.
- ↑ Ritchie DB, Woodside MT (October 2015). "Probing the structural dynamics of proteins and nucleic acids with optical tweezers". Curr Opin Struct Biol. 34: 43–51. doi:10.1016/j.sbi.2015.06.006. PMC 7126019 Check
|pmc=value (help). PMID 26189090. - ↑ Nelson, Philip; Goodsell, David S. (2014). Biological physics: energy, information, life; with new art by David Goodsell. New York, NY: Freeman. ISBN 978-0-7167-9897-2. Search this book on
- ↑ Walter, Nils; Woodson, Sarah A.; Batey, Robert T. (2008-11-18). Non-Protein Coding RNAs. Berlin: Springer Science & Business Media. ISBN 978-3-540-70840-7. Search this book on
- ↑ Bai, Y.L.; Zheng, Q.S.; Wei, Y.G. (2007-04-05). IUTAM Symposium on Mechanical Behavior and Micro-Mechanics of Nanostructured Materials. Dordrecht London: Springer Science & Business Media. ISBN 978-1-4020-5624-6. Search this book on
- ↑ "UCSF Scientists Help Guide Cancer Research to a Melding of Physics & Biology". UCSF. November 4, 2009. Retrieved December 28, 2023.
- ↑ "Cal, UCSF scientists form cancer research unit". SFGATE. October 27, 2009. Retrieved December 28, 2023.
- ↑ Yarris, Lynn (March 11, 2009). "Berkeley Scientists Find New Way to Get Physical in the Fight Against Cancer". Lawrence Berkeley National Lab. Retrieved December 28, 2023.
- ↑ Barker, Anna (March 23, 2010). "National Cancer Institute Research: Today's Progress; Tomorrow's Challenges" (PDF). NCI. Retrieved December 28, 2023.
- ↑ "FACT SHEET: At Cancer Moonshot Summit, Vice President Biden Announces New Actions to Accelerate Progress Toward Ending Cancer As We Know It". The White House, Office of the Press Secretary. June 28, 2016. Retrieved December 28, 2023.
- ↑ Suarez, Ray (January 12, 2017). "The 'Cancer Moonshot,' One Year After Takeoff". KQED/NPR. Retrieved December 28, 2023.
External links
- Website of the Liphardt Lab
- Jan Liphardt publications indexed by Google Scholar
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