Joseph Borg (scientist)
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Joseph Borg is an associate professor of Molecular Genetics and Experimental Haematology, at University of Malta. He has led Malta's first ever space bioscience mission to the International Space Station entitled Project Maleth studying human skin microbiomes obtained from Type 2 Diabetes Mellitus foot ulcers. The mission formed part of the SpaceX CRS23 that departed on the 29th of August 2021 from Cape Canaveral and returned to Earth on the 1st of October 2021 .[1]
Education[edit]
Borg completed his first undergraduate BSc (Hons) degree in Applied Biomedical Science from the University of Malta in 2004.[2] He did his PhD in Molecular Genetics and Haematology also from University of Malta in 2010.[2] His PhD on haemoglobin genes was supervised by Alex E. Felice. His thesis was entitled A Novel Mutation in the Human erythroid transcription factor KLF1 as a cause of hereditary persistence of foetal haemoglobin.[3]
Research and career[edit]
His work is focused on the understanding of the transcriptional regulation and control of erythropoiesis, with emphasis on the globin gene switch mechanism. He is known for his research in linking DNA variations in the human KLF1 gene and hereditary persistence of foetal haemoglobin.[4][5] Subsequent work unveiled the molecular genetics of the HPFH KLF1-related condition (613566)[6] and established KLF1 as a novel quantitative trait locus for HbF (HBFQTL6).[7] His research group is currently working in understanding the molecular mechanisms and gene control of developmental γ to β globin gene switching that occur during the shift of erythropoiesis from human foetal liver and spleen to the adult bone marrow.[8][9][10][11][12]
Awards and honours[edit]
Borg was awarded a Malta Government Scholarship, and later awarded both a short- and long- term EMBO fellowship to work at Erasmus MC, Rotterdam, on experimental haematology and control of erythropoiesis.[13] He later worked in the accession of Malta as a member state into the European Molecular Biology Conference,[14] and European Molecular Biology Laboratory.[15] and currently serves as the Maltese scientific delegate on both EMBC and EMBL councils.
References[edit]
- ↑ "Malta to send scientific experiment to the International Space Station". MFEA. 2021-05-15. Retrieved 2021-09-21.
- ↑ 2.0 2.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedvivo - ↑ "A Novel Mutation in the Human erythroid transcription factor KLF1 as a cause of hereditary persistence of foetal haemoglobin". online library thesis. University of Malta. Retrieved 21 November 2021.
- ↑ Borg, Joseph; et al. (August 2010). "Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin". Nature Genetics. 42 (9): 801–5. doi:10.1038/ng.630. PMC 2930131. PMID 20676099.
- ↑ Giardine, and Borg; et al. (March 2011). "Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach". Nature Genetics. 43 (4): 295–301. doi:10.1038/ng.785. PMC 3878152. PMID 21423179.
- ↑ 613566: omin.org
- ↑ HBFQTL6 (613566): omin.org
- ↑ "The KLF1 Gene - A Maltese Discovery". researchtrustmalta.eu. Retrieved 21 October 2018.
- ↑ Wilcockson, Scott. "Blood, Genes, and You". www.um.edu.mt. Think Magazine. Retrieved 23 October 2018.
- ↑ Grech, Godfrey; Grossman, Iris (2015). Preventive and Predictive Genetics: Towards Personalised Medicine. Springer. ISBN 9783319153445. Search this book on
- ↑ From Lab to Life: Thalassemia - The Hereditary Anaemia of the Mediterranean (Television). Malta: TVM. 1 May 2016.
- ↑ Jien min Jien? Il-Ġenetika (video) (Documentary). Science in the City Malta. 10 October 2014. Event occurs at 12. Retrieved 23 October 2018.
- ↑ "Defect in Maltese family sheds new light on anemia". Erasmus MC. 4 August 2010. Retrieved 21 October 2018.
- ↑ "The EMBO community welcomes Malta". EMBO. 21 March 2016. Retrieved 21 October 2018.
- ↑ "member states - General information". EMBL. Retrieved 21 November 2021.
External links[edit]
- Joseph Borg publications indexed by Google Scholar
- Publications by Joseph Borg, at ResearchGate
- Government of Malta
- Esplora
- Tesmanian Blog
- Times of Malta
- Times of Malta
- Times of Malta
- Times of Malta
- Toppinup
- TVM
- TVM
- NASA
- ONE TV
- ONE TV
- ONE TV
- University of Malta
- University of Malta
- University of Malta
- Space Applications Services
- ESA
- NASA
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