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MILabs B.V.

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MILabs B.V.
Private
ISIN🆔
IndustryBiotechnology
Founded 📆2006 (2006) in Utrecht, the Netherlands
Founder 👔Prof. Frederik Beekman
Headquarters 🏙️, ,
The Netherlands
Area served 🗺️
Key people
Prof. Frederik Beekman, CEO
Products 📟 preclinical imaging systems
Members
Number of employees
🌐 Websitewww.milabs.com
📇 Address
📞 telephone

History[edit]

MILabs.[1], short for Molecular Imaging Labs, is a Dutch company headquartered in Houten, the Netherlands. MILabs was founded in 2006 by Prof. Freek Beekman[2] as a spin-off from the University Medical Centre Utrecht[3]. Their 2007 micro-SPECT scanner substantially increased both the imaging and timing resolution of mouse scans, drastically reducing the number of laboratory animals needed to answer specific research questions[4]. Today, MILabs is a global leader in preclinical molecular imaging with the development of high-performance micro-PET, micro-SPECT, micro-CT, and Optical Tomography systems, and hybrids thereof, as well as ultra-high resolution human SPECT. These imaging systems support the research of hundreds of universities and pharmaceutical companies, ranging from unraveling the origins of Parkinson's disease[4][5][6] and lung damage due to COVID-19[5][7] to the targeted treatment of cancer[5][8], to the imaging of ancient art objects[9].

In 2013, MILabs ranked 13th in the MKB Innovation Top-100[10].

In both 2015 and 2018, MILabs received the Innovation of the Year Award of the World Molecular Imaging Society (WMIS)[11][12].

Products[edit]

MILabs first products were U-SPECT and U-SPECT/CT systems[13][14][15][16], which today deliver sub-quarter-mm resolution in-vivo images of radiolabeled tracers.

In 2013, MILabs introduced their Versatile Emission Computed Tomography (VECTor[17]), an integrated multimodal SPECT, PET, and CT imaging technology that enables simultaneously sub-mm resolution PET and SPECT imaging. In addition, a prototype of a clinical ultra-high-resolution SPECT scanner (G-SPECT) was developed.

In 2015 MILabs launched the U-CT preclinical in-vivo micro-CT scanner, which can be integrated into existing multimodal platforms such as the MILabs SPECT/CT, PET/CT, Optical/CT and PET/SPECT/CT systems.

In 2016 MILabs launched a SPECT-based 3D autoradiography module and optical imaging modules. It enables single-run performance of SPECT, PET, bioluminescense & fluorescense tomography and micro-CT.

The latest MILabs PET technology offers positron range-free PET, also enabling simultaneous dual-isotope PET[18]

References[edit]

  1. "MILabs B.V." Retrieved 27 May 2020.
  2. "Prof. dr. Freek J. Beekman". Retrieved 27 May 2020.
  3. "Universitair Medisch Centrum". Retrieved 2 June 2020.
  4. 4.0 4.1 Korteweg, Niki (30 January 2007). "U-SPECT ziet het muizenmolecuul". NRC. Retrieved 31 March 2021. Unknown parameter |url-status= ignored (help)
  5. 5.0 5.1 5.2 "Biomedische 'Hubble-telescoop' kreeg boost door Innovatiekrediet | RVO.nl | Rijksdienst". www.rvo.nl (in Nederlands). Retrieved 2021-03-31.
  6. Kim, Sangjune; Kwon, Seung-Hwan; Kam, Tae-In; Panicker, Nikhil; Karuppagounder, Senthilkumar S.; Lee, Saebom; Lee, Jun Hee; Kim, Wonjoong Richard; Kook, Minjee; Foss, Catherine A.; Shen, Chentian (2019-08-21). "Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease". Neuron. 103 (4): 627–641.e7. doi:10.1016/j.neuron.2019.05.035. ISSN 0896-6273. PMC 6706297 Check |pmc= value (help). PMID 31255487.
  7. Molotkov, Andrei; Bhatt, Nikunj; Doubrovin, Mikhail; Castrillon, John; Massa, Christopher; Gerber, Adam; D’Armiento, Jeanine; Goldklang, Monica; Mintz, Akiva (2020-12-20). "Multimodality molecular imaging of the alveolar-capillary barrier in lung disease using albumin based optical and PET tracers". Molecular Biomedicine. 1 (1): 17. doi:10.1186/s43556-020-00020-1. ISSN 2662-8651. PMC 7749789 Check |pmc= value (help).
  8. Abou, Diane S.; Rittenbach, Andrew; Tomlinson, Ryan E.; Finley, Paige A.; Tsui, Benjamin; Simons, Brian W.; Ulmert, David; Riddle, Ryan C.; Thorek, Daniel LJ (2018-09-26). "First Whole-Body Three-Dimensional Tomographic Imaging of Alpha Particle Emitting Radium-223". bioRxiv: 414649. doi:10.1101/414649. Unknown parameter |s2cid= ignored (help)
  9. Balen, Erna van (2020-02-17). "Nederlanders kraken per ongeluk geheimen Chinese puzzelballen". de Volkskrant (in Nederlands). Retrieved 2021-03-31.
  10. "NRC Handelsblad van woensdag 12 juni 2013". NRC (in Nederlands). Retrieved 2021-03-31.
  11. "WMIS Introduces New Award at WMIC 2015, Commercial Innovation of the Year Award, Presented to MILabs for Work in SPECT Imaging". Retrieved 27 May 2020.
  12. "WMIS Presents 2018 Commercial Innovation of the Year Award to MILabs for VECTor-6 Broadband Photon Tomography". World Molecular Imaging Society. 2018-10-15. Retrieved 2021-03-31.
  13. Ivashchenko, O.; Van Der Have, F.; Villena, J. L.; Groen, H. C.; Ramakers, R. M.; Weinans, H. H.; Beekman, F. J. (2014). "Quarter-millimeter-resolution Molecular Mouse Imaging With U-SPECT⁺". Molecular Imaging. PubMed®. 13: 7290.2014.00053. doi:10.2310/7290.2014.00053. PMID 25429783. Retrieved 27 May 2020. Unknown parameter |s2cid= ignored (help)
  14. Ivashchenko, O.; Van Der Have, F.; Goorden, M. C.; Ramakers, R. M.; Beekman, F. J. (2015). "Ultra-high-sensitivity Submillimeter Mouse SPECT". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PubMed®. 56 (3): 470–5. doi:10.2967/jnumed.114.147140. PMID 25678487. Retrieved 27 May 2020. Unknown parameter |s2cid= ignored (help)
  15. Van Der Have, F.; Ivashchenko, O.; Goorden, M. C.; Ramakers, R. M.; Beekman, F. J. (2016). "High-resolution Clustered Pinhole (131)Iodine SPECT Imaging in Mice". Nuclear Medicine and Biology. PubMed®. 43 (8): 506–11. doi:10.1016/j.nucmedbio.2016.05.015. PMID 27289328. Retrieved 27 May 2020.
  16. De Swart, J.; Chan, H. S.; Goorden, M. C.; Morgenstern, A.; Bruchertseifer, F.; Beekman, F. J.; De Jong, M.; Konijnenberg, M. W. (2016). "Utilizing High-Energy γ-Photons for High-Resolution 213Bi SPECT in Mice". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PubMed®. 57 (3): 486–92. doi:10.2967/jnumed.115.157685. PMID 26635343. Retrieved 27 May 2020. Unknown parameter |s2cid= ignored (help)
  17. Goorden, M. C.; Van Der Have, F.; Kreuger, R.; Ramakers, R. M.; Vastenhouw, B.; Burbach, J. P.; Booij, J.; Molthoff, C. F.; Beekman, F. J. (17 Oct 2012). "VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PubMed®. 54 (2): 306–12. doi:10.2967/jnumed.112.109538. PMID 23077113. Retrieved 27 May 2020. Unknown parameter |s2cid= ignored (help)
  18. "Prompt gammas enable sub-millimetre-resolution, multi-isotope PET". Physics World. 2021-03-05. Retrieved 2021-03-31.

External links[edit]


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