Malcolm Rowland
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Malcolm Rowland FBPhS[1] (born August 5, 1939, London) is Emeritus Professor of Pharmacy, University of Manchester[2], and Adjunct Professor, University of California San Francisco. His research in pharmacology, particularly engaging in pioneering activities in physiologically based pharmacokinetics (that deals with the movement in time of drugs and their metabolites within the body) has helped revolutionise the approach to the selection, development and use of drugs[3]. He has written several textbooks on the subject with an emphasis on concepts and clinical applications.
He studied Pharmacy at Chelsea College (now Kings College), an internal college of the University of London, gaining a B.Pharm (1961) and subsequently a Ph.D (1965).
Academic career[edit]
Following his Ph.D. degree research into the pharmacokinetics of amphetamines[4], Malcolm took up a postdoctoral research appointment in the laboratory of Professor Sidney Riegelman, School of Pharmacy, University of California, San Francisco (1965-1967), studying the pharmacokinetics of aspirin, before taking up a faculty position at that institution (1967-75). During his time at UCSF[5] . Malcolm became a member of the joint Pharmacy-Medicine NIGMS funded program in Clinical Pharmacology, co-directed by Kenneth Melmon and Sidney Riegelman, and moved his research from a prevailing descriptive approach to a more mechanistic, physiologically-based one[6], including the clearance concept[7],[8] , that helped lay the foundations of modern pharmacokinetics. Together with Sidney Riegelman and Leslie Benet he founded the Journal of Pharmacokinetics and Biopharmaceutics (1973)[9] (renamed Journal of Pharmacokinetics and Pharmacodynamics, 2001), and was a senior editor of it until 2007.
In 1975 Malcolm returned to the United Kingdom to take up a position of Professor of Pharmacy, University of Manchester where he extended his research on physiologically based pharmacokinetics[10],[11], including development of an in silico method for predicting tissue distribution of drugs based on tissue composition and physicochemical properties[12]. In 1983 he founded Medeval[13], undertaking early stage clinical evaluation of new medicines under development. Together with Brian Houston and Leon Aarons he established the Centre for Applied Pharmacokinetic Research (1996)[14]. He has promoted the application of microdosing in clinical drug development.[15],[16]
He headed the School of Pharmacy at Manchester on two occasions, 1988-1991 and 1998-2001, the first spearheading the move to clinical pharmacy and the latter moving Pharmacy from the Faculty of Science and Engineering to the Faculty of Medicine, in recognition of the changing professional role of pharmacists from fabricator to health care advisor on medicines. Malcolm has trained 90 Ph.D. students and scientists from a variety of disciplines. He also established ongoing annual postgraduate workshops in basic pharmacokinetics with Tomas Tozer (1977), and in advanced methods in pharmacokinetics and pharmacodynamics with Lewis Sheiner (1981).[17]
Malcolm was president of EUFEPS (European Federation for Pharmaceutical Sciences, 1996-1999)[18], and a Vice-President of FIP (International Pharmaceutical Federation,2001-2009).[19]
Published works[edit]
Rowland has published over 270 research articles in international peer-reviewed journals, and over 60 book chapters and conference reports. He co-authored with Thomas Tozer two standard textbooks: Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, now in its 5th edition, and Essentials of Pharmacokinetics and Pharmacodynamics.[20]
Honours and Awards[edit]
He received honorary degrees from University of Poitiers, France (D.Sc.1981), Uppsala University , Sweden (FarmDhc, 1989)[21], and Athens University, Greece ( D.Sc., 2011)[22]. He was made Fellow, Academy of Medical Sciences (2001), Fellow, British Pharmacological Society (2012), and Honorary Fellow, American College of Clinical Pharmacology (2003)[23]. He received the Scheele Award (Swedish Academy of Pharmaceutical Sciences, 1984)[24], the Distinguished Investigator Award (American College of Clinical Pharmacology, 2007), the New Safe Medicines Faster Award (EUFEPS, 2009), Research Achievement Award in Pharmacokinetics (American Association of Pharmaceutical Scientists, 1994)[25], the Sheiner-Beal Award in Pharmacometrics (American Society of Clinical Pharmacology and Therapeutics, 2012)[26] and the Ariens Award (Dutch Pharmacological Society, 2020)[27]., as well as the Harrison Memorial Medal (Royal Pharmaceutical Society of Great Britain, 1992)[28] and Host Madsen Medal (International Pharmaceutical Federation, 2011)[29]
Personal life[edit]
Malcolm married Dawn Shane, in 1965. They have two daughters, Lisa Claire and Michelle Zena, and 5 grandchildren.
References[edit]
- ↑ https://www.bps.ac.uk/about/who-we-are/fellows-directory/professor-malcolm-rowland/f9fc56b2-d7f6-e311-88a7-001dd8b721a7
- ↑ "Search for people | the University of Manchester".
- ↑ "Distinguished Pharmaceutical Scientist: Malcolm Rowland (2006)". YouTube.
- ↑ https://catalogue.libraries.london.ac.uk/search~S16?/aRowland%2C+M./arowland+m/-3%2C-1%2C0%2CB/frameset&FF=arowland+m&1%2C1%2C
- ↑ "1967–1978: The Riegelman Chairship · History of the Department of Bioengineering and Therapeutic Sciences".
- ↑ N Benowitz, F P Forsyth, K L Melmon, M Rowland (1974). Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model. Clin Pharmacol Ther. Jul;16(1):87-98. https://doi.org/10.1002/cpt1974161part187
- ↑ Malcolm Rowland, Leslie Z. Benet & Garry G. Graham (1973). Clearance concepts in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics. Apr;1(2):123-36. https://link.springer.com/article/10.1007/BF01059626
- ↑ K Sandy Pang, Malcolm Rowland (1977). Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. Journal of Pharmacokinetics Biopharmaceutics. Dec;5(6):625-53. https://link.springer.com/article/10.1007/BF01059688
- ↑ Bonate, Peter L. (2020). "On the shoulders of giants…". Journal of Pharmacokinetics and Pharmacodynamics. 47 (1): 1. doi:10.1007/s10928-020-09674-4. PMID 31960232. Unknown parameter
|s2cid=ignored (help) - ↑ Michael S. Roberts & Malcolm Rowland (1986). A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations. Journal of Pharmacokinetics and Biopharmaceutics 14, 227–260. https://link.springer.com/article/10.1007%2FBF01106706
- ↑ Cheung, S.Y.A., Rodgers, T., Aarons, L., Gueorguieva, I, Dickenson, G.L., Murby, S, Brown, C., Collins, B., Rowland, M (2018). Whole body physiologically based modelling of beta-blockers in the rat: Events in tissues and plasma following an intravenous bolus dose. Brit. J. Pharmacol. 175 67-83. PMID: 29053169, DOI: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14071
- ↑ Rodgers, T. and Rowland, M (2006). Physiologically-Based Pharmacokinetic Modeling 2: Predicting the Tissue Distribution of Acids, Very Weak Bases, Neutrals and Zwitterions. J. Pharm. Sci. 95 1238-57. PMID: 16639716 DOI: https://jpharmsci.org/article/S0022-3549(16)32034-2/fulltext
- ↑ "Drug development | the University of Manchester".
- ↑ https://www.capkr.manchester.ac.uk
- ↑ Graham Lappin, Yoko Shishikura, Roeline Jochemsen, Richard John Weaver, Charlotte Gesson, Brian Houston, Berend Oosterhuisd, Ole J. Bjerrum, Grzegorz Grynkiewiczf, Jane Alder, Malcolm Rowland, Colin Garner (2011). Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers. Eur. J. Pharm. Sci 2011, 43 141–150; PMID: 21540108, DOI: https://www.sciencedirect.com/science/article/abs/pii/S0928098711001047?via%3Dihub
- ↑ Tal Burt, Graeme Young, Wooin Lee, Hiroyuki Kusuhara, Oliver Langer, Malcolm Rowland, Yuichi Sugiyama (2020). Phase-0 including microdosing approaches: Time for mainstream application in drug development? Nature Reviews Drug Discovery Development. 19: 801-818. PMID: 32901140, DOI: https://www.nature.com/articles/s41573-020-0080-x
- ↑ https://www.pkworkshops.com
- ↑ https://https://www.eufeps.org/History.html
- ↑ "Structure and statutes".
- ↑ https://pharmacy.lwwhealthlibrary.com/book.aspx?bookid=2695
- ↑ https://www.uu.se/en/about-uu/traditions/prizes/honorary-doctorates/pharmacy/
- ↑ http://old.pharm.uoa.gr/an8ropino-dynamiko/epitimoi-didaktores.html
- ↑ https://accp1.org/members/ACCP1/6Members/Past_Award_Winners.aspx
- ↑ https://www.apotekarsocieteten.se/en/scholarships-and-prizes/scheele-award/former-laurates/
- ↑ https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/Awards_page/historical_awards.pdf
- ↑ https://www.ascpt.org/Portals/28/docs/Awards/Criteria%20and%20Past%20Recipients/2021%20Awards/Award%20Criteria%20and%20Past%20Recipients%202021%20Sheiner-Beal.pdf?ver=2021-05-03-114840-033
- ↑ https://nvfarmacologie.nl/awards/ariens-award/
- ↑ https://www.rpharms.com/about-us/news/details/Hanbury-and-Harrison-Medal-winners
- ↑ https://www.fip.org/awards#Host-Madsen-Medal
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