Narcolepsy Introduction Information
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Article Draft: Narcolepsy[edit]
Treatment[edit]
People with narcolepsy can be substantially helped, but not cured. However, the technology exists in early form such as experiments in using the prepro-orexin transgene via gene editing restored normal function in mice models by making other neurons produce orexin after the original set have been destroyed or replacing the missing orexinergic neurons with hypocretin stem cell transplantation are both steps in that direction for fixing the biology effectively permanently once applied in humans. Additionally effective ideal non-gene editing and chemical-drug methods involve hypocretin treatments methods such as future drugs like hypocretin agonists (such as TAK-994) which the enterprise targets it to be available by 2024 or hypocretin replacement, in the form of hypocretin 1 given intravenous (injected into the veins), intracisternal (direct injection into the brain), and intranasal (sprayed through the nose), the latter being low in efficacy, at the low amount used in current experiments but may be effective at very high doses in the future.
General strategies like people and family education, sleep hygiene and medication compliance, and discussion of safety issues for example driving license can be useful. Potential side effects of medication can also be addressed. Regular follow-up is useful to be able to monitor the response to treatment, to assess the presence of other sleep disorders like obstructive sleep apnea, and to discuss psychosocial issues.
Sleep Hygiene[edit]
Individuals with Narcolepsy (type 1 &2) tend have poor and unrefreshing nighttime sleep. Consistent daily habits can help to improve sleep hygiene and improve the quality of nighttime sleep. Some practical tips for how to improve sleep hygiene are below [1]
Keep a consistent wake time and bedtime. Maintaining a regular sleep schedule can help an individual's body adjust to a schedule that works best for them.
Avoid caffeine late in the day. Caffeine consumption later in the day, such as after lunch, may impact one's ability to fall asleep at a regularly desired time.
Limit electronic use. Electronic devices can put off what is called a "blue light." This blue light can be simulating to the brain.[1]
References[edit]
- ↑ 1.0 1.1 Mansukhani, Meghna P.; Kolla, Bhanu Prakash; Ramar, Kannan (March 2014). "International Classification of Sleep Disorders 2 and American Academy of Sleep Medicine Practice Parameters for Central Sleep Apnea". Sleep Medicine Clinics. 9 (1): 1–11. doi:10.1016/j.jsmc.2013.10.006. ISSN 1556-407X.
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These are very nice proposed additions! I might make one suggestion, reading this section I wonder if reorganization/restructuring of the existing article might be beneficial? For instance two paragraphs being nearly the same way "Another...". It feels redundant to me. Do you think subheaders for each treatment described might be helpful? Or some other form of organization that doesn't leave it to the reader to scan through paragraphs to find the drug names? (LIZ)
[1] American Academy of Sleep Medicine. (2014). International Classification of Sleep Disorders. (Third Edition). American Academy of Sleep Medicine. https://aasm.org/
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