Vitamin A5
Vitamin A5 is a group of compounds, including 9-cis-13,14-dihydroretinol as vitamin A5 alcohol [1] [2] and 9-cis-13,14-dihydroretinoic acid [3] as the active derivative and the endogenous relevant activator of the retinoid-X receptors (RXRs) [3] as confirmed in various review articles [4] [5] [6].
Vitamin A5 has thereby putative actions similar to those of vitamin A [1] serving as a precursor of ligands of nuclear hormone receptors, comparable to retinol / vitamin A1 functioning as a nutritional precursor for all-trans-retinoic acid, the endogenous ligand for the retinoic acid receptors (RARs) [7].
As of 2021, this model system was under laboratory research.[2][8]
References[edit]
- ↑ 1.0 1.1 Rühl R, Krężel W, de Lera AR (2018). "9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of the retinoid X receptor and the active ligand of a potential new vitamin category: vitamin A5". Nutrition Review. 76 (12): 929–941. doi:10.1093/nutrit/nuy057. PMID 30358857.
- ↑ 2.0 2.1 Krężel W, Rivas A, Szklenar M, Ciancia M, Alvarez R, de Lera AR, Rühl R (2021). "Vitamin A5/X, a new food to lipid hormone concept for a nutritional ligand to control RXR-mediated signaling". Nutrients. 13 (3): 925. doi:10.3390/nu13030925. PMC 7999121 Check
|pmc=value (help). PMID 33809241 Check|pmid=value (help). - ↑ 3.0 3.1 Rühl R, Krzyżosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, Wietrzych-Schindler M, Álvarez S, Szklenar M, Nagy L, de Lera AR, Krężel W (2015). "9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice". PLOS Genetics. 11 (6): e1005213. doi:10.1371/journal.pgen.1005213. PMC 4451509. PMID 26030625.
- ↑ de Lera AR, Krężel W, Rühl R (2016). "An endogenous mammalian retinoid X receptor ligand, at last!". ChemMedChem. 11 (10): 1027–1037. doi:10.1002/cmdc.201600105. PMID 27151148.
- ↑ Krężel W, Rühl R, de Lera AR (2019). "Alternative retinoid X receptor (RXR) ligands". Mol Cell Endocrinol. Jul1 (491): 110436. doi:10.1016/j.mce.2019.04.016. PMID 31026478.
- ↑ Bohn T, Bonet ML, Borel P, Keijer J, Landrier JF, Milisav I, Ribot J, Riso P, Winklhofer-Roob B, Sharoni Y, Corte-Real J, van Helden Y, Loizzo MR, Poljsak B, Porrini M, Roob J, Trebse P, Tundis R, Wawrzyniak A, Rühl R, Dulińska-Litewka J (2021). "Mechanistic aspects of carotenoid health benefits - where are we now?". Nutr Res Rev. 31 (5): 1–27. doi:10.1017/S0954422421000147. PMID 34057057 Check
|pmid=value (help). - ↑ Petkovich M, Brand NJ, Krust A, Chambon P (1987). "A human retinoic acid receptor which belongs to the family of nuclear receptors". Nature. 330 (6147): 444–50. doi:10.1038/330444a0. PMID 2825025.
- ↑ Krzyżosiak A, Podleśny-Drabiniok A, Vaz B, Alvarez R, Rühl R, de Lera AR, Krężel W (2021). "Vitamin A5/X controls stress-adaptation and prevents depressive-like behaviors in a mouse model of chronic stress". Neurobiol Stress. 3 (15): 100375. doi:10.1016/j.ynstr.2021.100375. PMC 8355947 Check
|pmc=value (help). PMID 34401411 Check|pmid=value (help).
This article "Vitamin A5" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Vitamin A5. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
