Alev Erisir
Alev Erisir (born March 15, 1961) is a Turkish-born neuroscientist studying synapse development and sensory circuit structures. Her primary research areas include neuronal connectivity in the visual and taste systems, synaptic proteins, and ultrastructural neuroanatomy. Furthermore, Erisir has conducted studies on the plasticity of neurons in sensory systems and the fine structure of synaptic circuitry in developing and aging brains. Her lab analyzes Alzheimer's mouse models, examining the association between ultrastructural molecular changes and mild cognitive deficits in the mice. For her research, Erisir utilizes serial electron microscopy, tract-tracing, immunolabeling, and 3D reconstruction methods on animal models including the rat and treeshrew.[1]
Erisir served as the Chair of the Psychology Department (2016-2021) and is a professor of neuroscience at the University of Virginia in Charlottesville, Virginia.[1]
Early Life and Education[edit]
Erisir was born in Kastamonu, Turkey. Her father was stationed in Kastamonu as a malaria eradication doctor. As an infant, Erisir moved with her family to Canakkale, Turkey, where she grew up until the age of 11. The family then moved to Istanbul, Turkey, where Erisir completed her secondary education. In 1986, following high school graduation, Erisir attended Istanbul University School of Medicine and received her MD. She attributed her decision to attend medical school partially to the influence of her father’s career as well as to increasing women’s rights, which included “seeing more women taking professional roles in society.”[1] After graduating Istanbul University, Erisir worked in an emergency room for about a year, an experience that helped her realize her preference for work in research and prompted her interest in graduate programs.[1] In 1996, Erisir graduated from the State University of New York at Stony Brook with a PhD in Behavioral Neuroscience[2].
Research and Career[edit]
Erisir completed Postdoctoral training at New York University (NYU) Center for Neural Science. She completed her training under the guidance of Chiye Aoki. In Aoki’s laboratory, Professor Erisir trained specifically in Electron Microscopy. After completing her training at NYU, Erisir completed a one-year postdoctoral appointment at New York Medical College (NYMC) in the department of Physiology. Following her time at NYMC, Erisir returned to NYU this time as a Research Assistant Professor.[1]
In 2000, Erisir started working at University of Virginia (UVA) as an assistant professor. In 2013 she was granted professor status at UVA. During her time at UVA Erisir has served in several administrative roles including co-director of the neuroscience graduate program, director of the cognitive science program, and director of the neuroscience undergraduate program. In 2016 she was appointed to be the chair of the Psychology department at UVA.[1]
As a professor of neuroscience Erisir has taught several courses at both the graduate and undergraduate level, these courses include: Neural mechanisms of Behavior, Psychobiology laboratory, Psychopharmacology, Neuroplasticity, and Functional Neuroanatomy.[1]
At UVA, Erisir’s research has consisted of investigating ocular dominance column plasticity using several different techniques, brain stem gustatory circuitry, the aging brain and its pathology, and three-dimensional connectomics.[1]
Dr. Erisir conducts studies on cellular mechanisms within the aging brain and neurodegenerative diseases such as Alzheimer’s disease[3]. Her work examines the relationship between hyperactive oligodendrocytes and cognitive impairments in Alzheimer’s mouse models[3]. Additionally, Dr. Erisir’s research examines proteins such as beta-amyloid and tau that result in the loss of synaptic plasticity[4]. Her studies contribute to ongoing efforts to identify potential new drug targets for Alzheimer's therapy[4].
Erisir has also served as a mentor for several undergraduate and graduate students. She cited this as one of her favorite aspects of her job. In 2008, Erisir received a University of Virginia Mead Grant, which funded an opportunity for Erisir to take undergraduates to the annual Society of Neuroscience conference.[5] In 2010 she mentored a research project that investigated rodent neural circuitry between the brainstem and the oral cavity. This project was selected by the University of Virginia to receive the "Double Hoo" Grant.[6] Script error: No such module "AfC submission catcheck".
Selected Publications[edit]
- Campbell C, Lindhartsen S, Knyaz A, Erisir A, Nahmani M. Cortical Presynaptic Boutons Progressively Engulf Spinules As They Mature. eNeuro. 2020 Sep 18:ENEURO.0426-19.2020. doi: 10.1523/ENEURO.0426-19.2020. Epub ahead of print. PMID: 32958478.
- Sanchez V, Bakhti-Suroosh A, Chen A, Brunzell DH, Erisir A, Lynch WJ. 2019. Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine-seeking following extended access self-administration. Eur J Neurosci. 2019 Aug;50(4):2707-2721. doi: 10.1111/ejn.14408. Epub 2019 Apr 9.
- Wang L, Kloc M, Maher E, Erisir A, Maffei A. 2019 Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1. Cereb Cortex. 2019 Mar 1;29(3):921-936. doi: 10.1093/cercor/bhx364.
- Schecter RW, Maher EE, Welsh CA, Stevens B, Erisir A, Bear MF, 2017 Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1. J Neurosci. 2017 Nov 1;37(44):10541-10553.
- Irwin JA, Erisir A, Kwon I. Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model. Curr Alzheimer Res. 2016;13(6):663-77.
- Holtz SL, Fu A, Loflin W, Corson JA, Erisir A. Morphology and connectivity of parabrachial and cortical inputs to gustatory thalamus in rats. J Comp Neurol. 2015 Jan 1;523(1):139-61.
- Corson JA, Erisir A. Monosynaptic convergence of chorda tympani and glossopharyngeal afferents onto ascending relay neurons in the nucleus of the solitary tract: a high-resolution confocal and correlative electron microscopy approach. J Comp Neurol. 2013 Sep 1;521(13):2907-26.
- Owe SG, Erisir A, Heggelund P. Terminals of the major thalamic input to visual cortex are devoid of synapsin proteins. Neuroscience. 2013 Jul 23;243:115-25.
- Wang S, Corson J, Hill D, Erisir A. 2012. Postnatal development of chorda tympani axons in the rat nucleus of the solitary tract. J Comp Neurol. 2012 Mar 20.
- Corson J, Aldridge A, Wilmoth K, Erisir A. 2012. A survey of oral cavity afferents to the rat nucleus tractus solitarii. 2012. J Comp Neurol. 2012 Feb 15;520(3):495-527.
- Corson J, Nahmani M, Lubarsky K, Badr N, Wright C, Erisir A. Sensory activity differentially modulates N-methyl-D-aspartate receptor subunits 2A and 2B in cortical layers. Neuroscience. 2009 Oct 20;163(3):920-32.
- Kielland A, Erisir A, Walaas SI, Heggelund P. 2006. Synapsin utilization differs among functional classes of synapses on thalamocortical cells. Journal of Neuroscience. May 24;26(21):5786-93.
- Angeline S. Lillard, Alev Erisir. Old dogs learning new tricks: Neuroplasticity beyond the juvenile period, Developmental Review, Volume 31, Issue 4, December 2011, Pages 207-239.
- Coleman JE, Nahmani M, Gavornik JP, Haslinger R, Heynen AJ, Erisir A, Bear MF. Rapid structural remodeling of thalamocortical synapses parallels experience-dependent functional plasticity in mouse primary visual cortex. J Neurosci. 2010 Jul 21;30(29):9670-82.
- May OL, Erisir A, Hill DL. Ultrastructure of primary afferent terminals and synapses in the rat nucleus of the solitary tract: comparison among the greater superficial petrosal, chorda tympani, and glossopharyngeal nerves. J Comp Neurol. 2007 Jun 20;502(6):1066-78.
References[edit]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "Episode 01: Alev Erisir, MD PhD". Conjugate: Illustration and Science Blog. Retrieved 2021-04-27.
- ↑ Albright, Thomas; Squire, Larry, eds. (1998). "S. Murray Sherman". The History of Neuroscience in Autobiography. 10. Search this book on
- ↑ 3.0 3.1 "Episode 01: Alev Erisir, MD PhD". Conjugate: Illustration and Science Blog. Retrieved 2021-04-27.
- ↑ 4.0 4.1 "U.Va. Scientists Identify 'Missing Link' in Process Leading to Alzheimer's Disease". UVA Today. 2007-02-06. Retrieved 2021-04-28.
- ↑ Ford, Jane (October 14, 2008). "TEN PROFESSORS WIN MEAD GRANTS TO FOSTER FACULTY-STUDENT INTERACTION" (PDF). UVA Today. Retrieved April 28, 2021.
- ↑ "U.Va. Awards Eight Double-'Hoo Research Grants". UVA Today. 2010-04-05. Retrieved 2021-04-28.
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