Christoph Merten
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| Professor Christoph Merten | |
|---|---|
 Christoph_Merten_in_2021.jpg Christoph Merten in 2021 | |
| Born | July 31, 1976 Bielefeld, Germany |
| 🏳️ Nationality | German |
| 💼 Occupation | Professor and entrepreneur |
| Known for | Development of droplet-based microfluidic technologies for biomedical applications |
| 🌐 Website | https://www.epfl.ch/labs/lbmm/ |
Christoph Merten (born July 31, 1976) is a German bio-engineer and entrepreneur; currently Associate Professor at EPFL (École Polytechnique Fédérale de Lausanne).[1] He is an adjunct scientist at the Ludwig Institute for Cancer Research in Lausanne.[2][3][4] His research focuses on developing biomedical microfluidics technologies for drug discovery, diagnostics, and personalized therapy in cancer research[5]
Career[edit]
Merten was born in Bielefeld and graduated in 1999 with a diploma in biochemistry from the Goethe University in Frankfurt, where he also studied organic chemistry until his intermediate degree (Vordiplom). He then pursued a Ph.D. at the Paul Ehrlich Institute, where he worked on the directed evolution of retroviral vectors, graduating in 2004. He then moved to the University of Cambridge, where he worked as a postdoctoral researcher at the Medical Research CouncilLaboratory for Molecular Biology, focusing on high-throughput screening using emulsion technologies..[6] In 2005, he started a second postdoctoral appointment at the Institut de science et d'ingénierie supramoléculaires (ISIS) in Strasbourg, France.[7] He focused on droplet-based microfluidics for cellular assays and started his research group in 2007. From 2010 to 2019, he served as a group leader at the European Molecular Biology Laboratory in Heidelberg, where he established high-throughput droplet-based microfluidic screening platforms.[8] In 2019, he was named associate professor of bioengineering at EPFL[9][10] and currently leads the laboratory for biomedical microfluidics (LBMM) within the School of Engineering.[11] He also holds an adjunct scientist position at the Ludwig Institute for Cancer Research's Lausanne branch.[12]
Research[edit]
During his Ph.D. in the laboratory of Christian Buchholz at the Paul Ehrlich Institute, Merten's research focused on developing gene therapy vectors using directed evolution.[13][14][15] As a postdoctoral researcher, he developed novel droplet-based technologies, notably allowing higher throughput and minimal sample volumes in biological screening assays.[16]
His laboratory currently uses droplet-based approaches to address questions related to personalized medicine, biological screening assays, and genomics. In the context of cancer therapy, this work has allowed cost-efficient screening of numerous drug combinations on tumor samples issued from patient biopsies, enabling rapid determination of personalized treatment regimens for cancer patients.[17][18]
His research yielded technologies improving the discovery of therapeutic antibodies.[19][20]
Entrepreneurship[edit]
In 2017, Merten co-founded Velabs Therapeutics, a biotechnology startup aiming to develop droplet microfluidics technologies to screen therapeutic antibodies.[21] In 2019, the company announced that it had successfully closed a financing round worth €3 million.[22]
Merten is also a co-founder of TheraMe!, a consortium that aims to develop technologies allowing personalized cancer therapies.[23]
Selected publications[edit]
- Clausell-Tormos, Jenifer; Lieber, Diana; Baret, Jean-Christophe; El-Harrak, Abdeslam; Miller, Oliver J.; Frenz, Lucas; Blouwolff, Joshua; Humphry, Katherine J.; Köster, Sarah; Duan, Honey; Holtze, Christian; Weitz, David A.; Griffiths, Andrew D.; Merten, Christoph A. (2008). "Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms". Chemistry & Biology. 15 (5): 427–437. doi:10.1016/j.chembiol.2008.04.004. PMID 18482695.
- Debs, B. E.; Utharala, R.; Balyasnikova, I. V.; Griffiths, A. D.; Merten, C. A. (2012). "Functional single-cell hybridoma screening using droplet-based microfluidics". Proceedings of the National Academy of Sciences. 109 (29): 11570–11575. Bibcode:2012PNAS..10911570D. doi:10.1073/pnas.1204514109. PMC 3406880. PMID 22753519.
- Chaipan, Chawaree; Pryszlak, Anna; Dean, Hansi; Poignard, Pascal; Benes, Vladimir; Griffiths, Andrew D.; Merten, Christoph A. (2017). "Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles". Cell Chemical Biology. 24 (6): 751–757.e3. doi:10.1016/j.chembiol.2017.05.009. PMID 28552581.
- Shembekar, Nachiket; Hu, Hongxing; Eustace, David; Merten, Christoph A. (2018). "Single-Cell Droplet Microfluidic Screening for Antibodies Specifically Binding to Target Cells". Cell Reports. 22 (8): 2206–2215. doi:10.1016/j.celrep.2018.01.071. PMC 5842027. PMID 29466744.
- Eduati, Federica; Utharala, Ramesh; Madhavan, Dharanija; Neumann, Ulf Peter; Longerich, Thomas; Cramer, Thorsten; Saez-Rodriguez, Julio; Merten, Christoph A. (2018). "A microfluidics platform for combinatorial drug screening on cancer biopsies". Nature Communications. 9 (1): 2434. Bibcode:2018NatCo...9.2434E. doi:10.1038/s41467-018-04919-w. PMC 6015045. PMID 29934552.
References[edit]
- ↑ "25 new professors appointed at the two Federal Institutes of Technology – ETH Board". Retrieved 2022-07-13.
- ↑ "Christoph Merten". people.epfl.ch. Retrieved 2021-02-24.
- ↑ ORCID. "Merten CA (0000-0001-8790-4659)". orcid.org. Retrieved 2021-02-24.
- ↑ "Biomedical microfluidics". www.unil.ch. Retrieved 2021-02-25.
- ↑ "LBMM". www.epfl.ch. Retrieved 2021-02-24.
- ↑ Biology, ©2022 MRC Laboratory of Molecular; Avenue, Francis Crick; Campus, Cambridge Biomedical; CB2 0QH, Cambridge; Uk. 01223 267000. "LMB Alumni List". MRC Laboratory of Molecular Biology. Retrieved 2022-03-08.
- ↑ Köster, Sarah; Angilè, Francesco E.; Duan, Honey; Agresti, Jeremy J.; Wintner, Anton; Schmitz, Christian; Rowat, Amy C.; Merten, Christoph A.; Pisignano, Dario; Griffiths, Andrew D.; Weitz, David A. (2008). "Drop-based microfluidic devices for encapsulation of single cells". Lab on a Chip. 8 (7): 1110. doi:10.1039/b802941e. ISSN 1473-0197.
- ↑ Shembekar, Nachiket; Chaipan, Chawaree; Utharala, Ramesh; Merten, Christoph A. (2016). "Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics". Lab on a Chip. 16 (8): 1314–1331. doi:10.1039/C6LC00249H. ISSN 1473-0197.
- ↑ Engineering, School of (2019-09-26). "Nominations of Professors at the School of Engineering".
- ↑ "25 new professors appointed at the two Federal Institutes of Technology | ETH-Board". www.ethrat.ch. Retrieved 2021-02-24.
- ↑ "LBMM". www.epfl.ch. Retrieved 2021-02-24.
- ↑ "Ludwig Cancer Research". Retrieved 2022-03-08.
- ↑ Merten, Christoph A.; Stitz, Jörn; Braun, Gundula; Medvedovska, Julia; Cichutek, Klaus; Buchholz, Christian J. (2006-03-01). "Fusoselect: cell–cell fusion activity engineered by directed evolution of a retroviral glycoprotein". Nucleic Acids Research. 34 (5): e41. doi:10.1093/nar/gkl053. ISSN 0305-1048. PMC 1408311. PMID 16540592.
- ↑ Merten, Christoph A.; Stitz, Jörn; Braun, Gundula; Poeschla, Eric M.; Cichutek, Klaus; Buchholz, Christian J. (2005-01-15). "Directed Evolution of Retrovirus Envelope Protein Cytoplasmic Tails Guided by Functional Incorporation into Lentivirus Particles". Journal of Virology. 79 (2): 834–840. doi:10.1128/JVI.79.2.834-840.2005. ISSN 0022-538X. PMC 538528. PMID 15613311.
- ↑ Merten, Christoph A.; Engelstaedter, Martin; Buchholz, Christian J.; Cichutek, Klaus (2003-01-05). "Displaying Epidermal Growth Factor on Spleen Necrosis Virus-Derived Targeting Vectors". Virology. 305 (1): 106–114. doi:10.1006/viro.2002.1778. ISSN 0042-6822. PMID 12504545.
- ↑ Clausell-Tormos, Jenifer; Lieber, Diana; Baret, Jean-Christophe; El-Harrak, Abdeslam; Miller, Oliver J.; Frenz, Lucas; Blouwolff, Joshua; Humphry, Katherine J.; Köster, Sarah; Duan, Honey; Holtze, Christian; Weitz, David A.; Griffiths, Andrew D.; Merten, Christoph A. (2008-05-19). "Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms". Chemistry & Biology. 15 (5): 427–437. doi:10.1016/j.chembiol.2008.04.004. ISSN 1074-5521. PMID 18482695.
- ↑ Eduati, Federica; Utharala, Ramesh; Madhavan, Dharanija; Neumann, Ulf Peter; Longerich, Thomas; Cramer, Thorsten; Saez-Rodriguez, Julio; Merten, Christoph A. (2018-06-22). "A microfluidics platform for combinatorial drug screening on cancer biopsies". Nature Communications. 9 (1): 2434. Bibcode:2018NatCo...9.2434E. doi:10.1038/s41467-018-04919-w. ISSN 2041-1723. PMC 6015045. PMID 29934552.
- ↑ "Miniature testing of drug pairs on tumor biopsies". ScienceDaily. Retrieved 2021-02-24.
- ↑ Shembekar, Nachiket; Hu, Hongxing; Eustace, David; Merten, Christoph A. (2018-02-20). "Single-Cell Droplet Microfluidic Screening for Antibodies Specifically Binding to Target Cells". Cell Reports. 22 (8): 2206–2215. doi:10.1016/j.celrep.2018.01.071. ISSN 2211-1247. PMC 5842027. PMID 29466744.
- ↑ Debs, Bachir El; Utharala, Ramesh; Balyasnikova, Irina V.; Griffiths, Andrew D.; Merten, Christoph A. (2012-07-17). "Functional single-cell hybridoma screening using droplet-based microfluidics". Proceedings of the National Academy of Sciences. 109 (29): 11570–11575. Bibcode:2012PNAS..10911570D. doi:10.1073/pnas.1204514109. ISSN 0027-8424. PMC 3406880. PMID 22753519.
- ↑ "About Velabs – Velabs". Retrieved 2021-02-24.
- ↑ "Velabs Therapeutics Announces €3 Million Series B Financing to Advance its Functional Antibody Screening Programme". www.b3cnewswire.com. Retrieved 2021-02-24.
- ↑ "Microfluidic platform for the best possible cancer therapy". www.gesundheitsindustrie-bw.de. Retrieved 2021-02-24.
External links[edit]
- Christoph Merten publications indexed by Google Scholar
- Website of EPFL's Laboratory of Biomedical Microfluidics
Category:1976 births
Category:Living people
Category:École Polytechnique Fédérale de Lausanne faculty
Category:German scientists
Category:Engineers
Category:Bioengineers
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