FAM231B
Lua error in Module:Infobox_gene at line 43: attempt to index field 'wikibase' (a nil value). FAM231B, or family with sequence similarity 231B, is a protein found in humans and is encoded by FAM231B gene.[1] Orthologs of FAM231B are only found back to primates.[2]
Gene[edit]
FAM231B is found on human Chromosome 1 on locus 1p36.13 running in the positive direction, surrounded by RNU1-6P upstream and transfer RNA-Gly 4-1 downstream.[3][4] There are no aliases of FAM231B.[5] Its mRNA sequence is 1312 base pairs long, with the coding sequence in region 343 through 852, and there is only one exon.[6]
Protein[edit]
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The protein is 169 amino acids long.[7] The molecular weight of the unprocessed protein is 18.2 kDa and the processed protein is 18.3 kDa.[8] The isoelectric point of the protein is 7.76 and a mixed charged cluster was found from amino acid 66 to 125.[9] Other features of the protein include a positive charge run and a negative charge run, both spanning 4 amino acids.[10]
The predicted secondary structure of the protein consists of many coils, 3 β-sheets and 5 α-helixes.[11] Potential post-translational modifications of the protein include myristoylation and sumoylation.[12][13] The mature protein is predicted to be transported to the nucleus.[14]
Expression in Tissues[edit]
FAM231B is highly regulated in brain tissue and the spinal cord.[15] From GeoProfiles, other tissues where expression is regulated are visceral fat, adipose, thyroid, breast, coronary artery, pancreas, colon, vaginal epithelium, smooth muscle, and fallopian tube epithelium.[16]
Regulation of Expression[edit]
FAM231B contains a Kozak consensus sequence surrounding the start codon nucleotides. The primary promoter region for the human FAM231B gene is 1443 base pairs long.[17]
Predicted regulation in the secondary structure are two stem loops in the 5' UTR and two more in the 3' UTR.[18]
Function[edit]
The function of the protein is not yet well understood in the scientific community. The protein contains domain of unknown function (DUF) 4741, which is part of the FAM231 family.[19]
Homology & Evolution[edit]
There are three human paralogs: FAM231A, FAM231C, and FAM231D and a comparison of the protein percent identity and similarity are found in the table below. There are three strict orthologs of FAM231B: in humans, the Pan troglodytes (Common chimpanzee), and the Papio anubis (Olive baboon). No other orthologs are found beyond primates.[20]
The evolutionary rate of FAM231B was compared to Fibrinogen and Cytochrome C. FAM231B is predicted to have evolved faster than both of the proteins compared.
Table of FAM231B Paralogs[edit]
| Protein name | Accession number | Sequence length | Percent identity | Percent similarity |
|---|---|---|---|---|
| FAM231B | NP_001297084.1 | 169 | - | - |
| FAM231A | NP_001269250.1 | 169 | 87.6 | 89.9 |
| FAM231C | NP_001297067.1 | 169 | 87.6 | 89.9 |
| FAM231D | NP_001335076.1 | 169 | 84.6 | 89.3 |
Table of FAM231B Orthologs[edit]
| Scientific name | Common name | Accession number | Sequence length | Percent identity | Percent similarity |
|---|---|---|---|---|---|
| Homo sapiens | Human | NP_001297084.1 | 169 | - | - |
| Pan troglodytes | Common chimpanzee | XP_009438255.2 | 169 | 97.0 | 97.6 |
| Papio anubis | Olive baboon | XP_009178303.1 | 214 | 84.6 | 89.9 |
References[edit]
- ↑ "protein FAM231B [Homo sapiens]". National Center for Biotechnology Information, U.S. National Library of Medicine. September 13, 2016.
- ↑ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2017-05-06.
- ↑ "Homo sapiens family with sequence similarity 231 member B (FAM231B), mRNA". National Center for Biotechnology Information, U.S. National Library of Medicine. September 13, 2016.
- ↑ "GeneLoc Integrated Map for Chromosome 1: Search Results". genecards.weizmann.ac.il. Retrieved 2017-04-29.
- ↑ "FAM231B Gene (Protein Coding)". GeneCards. February 25, 2017.
- ↑ "Homo sapiens family with sequence similarity 231 member B (FAM231B), mRNA". NCBI. September 13, 2016.
- ↑ "protein FAM231B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-06.
- ↑ Database, GeneCards Human Gene. "FAM231B Gene - GeneCards | F231B Protein | F231B Antibody". www.genecards.org. Retrieved 2017-05-06.
- ↑ Workbench, NCSA Biology. "SDSC Biology Workbench". workbench.sdsc.edu. Retrieved 2017-05-06.
- ↑ "FAM231B protein analysis with SAPS". SDSC Biology Workbench. April 13, 2017.
- ↑ Workbench, NCSA Biology. "SDSC Biology Workbench". workbench.sdsc.edu. Retrieved 2017-04-29.
- ↑ "PSORT II Prediction". psort.hgc.jp. Retrieved 2017-05-07.
- ↑ "ExPASy: SIB Bioinformatics Resource Portal - Home". www.expasy.org. Retrieved 2017-05-07.
- ↑ "PSORT II Prediction". psort.hgc.jp. Retrieved 2017-05-07.
- ↑ github.com/gxa/atlas/graphs/contributors, EMBL-EBI Expression Atlas development team. "Expression summary for FAM231B - homo sapiens < Expression Atlas < EMBL-EBI". www.ebi.ac.uk. Retrieved 2017-04-29.
- ↑ "FAM231B - GEO Profiles - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-04-29.
- ↑ "Genomatix - NGS Data Analysis & Personalized Medicine". Genomatix ElDorado. April 1, 2017.
- ↑ "The mfold Web Server". The RNA Institute, College of Arts and Sciences, State University of New York at Albany. April 1, 2017.
- ↑ "protein FAM231B [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-04-29.
- ↑ "BLAST: Basic Local Alignment Search Tool". National Center for Biotechnology Information, U.S. National Library of Medicine. March 6, 2017.
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