Ghost Red Blood Cell
A Ghost red blood cell is a type of blood cell formed by removal of the nucleus from eosinophilic epithelial cells while retaining the cytoplasm and a cell membrane.
There is a certain type of white blood cell called the eosinophil. And when the eosinophilic epithelial cells (type of cell that lines surfaces of the body) no longer have a nucleus and instead have cytoplasm and a cell membrane, it is known as a Ghost Cell.[1] Red blood cells lose their hemoglobin as they swell and dilute urine to the point where the cell membrane ruptures, leaving only the membrane and free hemoglobin. "Ghost" cells are those with empty membranes.[2] The cause of Ghost Cells is coagulative necrosis, which is an "accidental cell death typically caused by ischemia or infarction".[3][1]
Erythrocytes
Red blood cells, also known as erythrocytes, bind oxygen and distribute it throughout the body. This also occurs in large quantities, and the biocompatibility of ghost red blood cells is strong; they can circulate in the bloodstream for three months.[1]
Erythrocytes are shaped like a biconcave disc and turn into spheres in hypo-osmotic solutions and biconcave discs in iso-osmotic solutions.[4]
Found In
- Craniopharyngioma (Rathke pouch)
- Odontoma
- Ameloblastic fibroma
- Calcifying odontogenic cyst (Gorlin cyst)
- Pilomatricoma[5]
References
- ↑ 1.0 1.1 1.2 "Ghost Red Blood Cells - A Natural Drug Delivery System". Biomol GmbH - Life Science Shop. Retrieved 2022-04-20.
- ↑ "Ghost Cells - LabCE.com, Laboratory Continuing Education". www.labce.com. Retrieved 2022-04-20.
- ↑ "Coagulative necrosis", Wikipedia, 2021-06-16, retrieved 2022-04-20
- ↑ Hoffman JF (December 2016). "Biconcave shape of human red-blood-cell ghosts relies on density differences between the rim and dimple of the ghost's plasma membrane". Proceedings of the National Academy of Sciences of the United States of America. 113 (51): 14847–14851. doi:10.1073/pnas.1615452113. PMC 5187704. PMID 27930321.
- ↑ "Ghost cell", Wikipedia, 2021-02-28, retrieved 2022-04-20
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