Grant Goodwin
Grant Goodwin is the name of a Scotsman who died at the age of 30 in December 2008 from vCJD.[1] Professor Peter Rudge identified him as the first person in the world with heterozygous Methionine-Valine gene at amino acid 129 (aka "the prion gene") to die of the disease. Every other person who died from vCJD has had a homozygous Methionine-Methionine form of prion gene.[2] Of the overall Caucasian population, about 40% have two methionine-containing alleles, 10% have two valine-containing alleles, and the other 50% are heterozygous at this position.[3][4]
Symptoms[edit]
The personality of Goodwin "changed and he became depressed".[2] He exhibited "reclusive behaviour and jealousy towards his girlfriend."[5] In 2008, his parents took him home to Scotland from the Channel Islands, where he had been working as an engineer, when he complained of "pain in his legs and head". His father Tommy remarked that[1][2]
| “ | within three months, Grant couldn’t walk or talk...he became someone else. He was seeing things, he was paranoid; it was absolutely unbelievable what that illness actually does to people. | ” |
References[edit]
- ↑ 1.0 1.1 "CJD killed our son, now he's not even a statistic". DC Thomson Co Ltd. The Sunday Post. 22 September 2013.
- ↑ 2.0 2.1 2.2 "'My son caught human form of mad cow disease from his baby food'". The Scotsman. 18 December 2009.
- ↑ Saba, R; Booth, SA (2013). "The genetics of susceptibility to variant Creutzfeldt–Jakob disease". Public Health Genomics. 16 (1–2): 17–24. doi:10.1159/000345203. PMID 23548713.
- ↑ Sikorska, B; Liberski, PP (2012). Human prion diseases: from Kuru to variant Creutzfeldt–Jakob disease. Sub-cellular Biochemistry. Subcellular Biochemistry. 65. pp. 457–96. doi:10.1007/978-94-007-5416-4_17. ISBN 978-94-007-5415-7. PMID 23225013. Search this book on
- ↑ "Have you got the 'mad cow' gene? Why the disease could be about to strike again". Telegraph Media Group Limited. Telegraph of London. 11 July 2019.
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