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Hans-Günther Schmalz

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Hans-Günther Schmalz (born June 30, 1957) is a German chemist and Professor of Organic Chemistry at University of Cologne.


Schmalz studied chemistry at the Johann Wolfgang Goethe University in Frankfurt, completing his Diploma in 1983. In 1985, he finished his PhD, under the supervision of Gerhard Quinkert at the same university. After his postdoctoral fellowship at Princeton University, in New Jersey, USA, in the laboratory of Martin F. Semmelhack, he completed his habilitation between the years 1988 and 1993 as a Junior Research Group Leader at the Goethe-University in Frankfurt. In 1994, he was awarded a position as C3-Professor of Chemistry at the Technical University of Berlin, where he stayed until 1999. Since 1999, Schmalz has been a Professor of Organic Chemistry at University of Cologne.[1]

Research and Academic career[edit]

Schmalz' research is focused on stereoselective synthesis of natural products.[2] and their bioactive analogues, enantioselective transition metal catalysis and design of ligands[3], enzyme-triggered CO-releasing molecules[4] as well as inhibitors of protein-protein interactions[5]

Between 2008 and 2011, he was Dean of Faculty of Mathematics and Natural Sciences and between 2013 and 2017, he was Director of the Department of Chemistry at University of Cologne.


  • 1986–1989: Liebig Postdoctoral Fellowship (Chemical Industry Fund)
  • 1998: Champion of Teaching, TU-Berlin
  • 2006 and 2016: Albertus-Magnus Teaching Award, University of Cologne

Books (selection)[edit]

  • Schmalz, Hans-Günther (Hrsg.): Organic Synthesis Highlights IV, Wiley-VCH, Weinheim 2000, ISBN 3-527-29916-5 Search this book on Amazon.com Logo.png.
  • Schmalz, Hans-Günther; Wirth, Thomas (Hrsg.): Organic Synthesis Highlights V, Wiley-VCH, Weinheim 2003, ISBN 3-527-30611-0 Search this book on Amazon.com Logo.png.



  1. "Hans-Günther Schmalz". European Journal of Organic Chemistry. 2018 (4): 424–424. 2018-01-31. doi:10.1002/ejoc.201800009. ISSN 1099-0690.
  2. Termath, Andreas Ole; Velder, Janna; Stemmler, René T.; Netscher, Thomas; Bonrath, Werner; Schmalz, Hans-Günther (2014-06-01). "Total Synthesis of (2RS)-α-Tocopherol through Ni-Catalyzed 1,4-Addition to a Chromenone Intermediate". European Journal of Organic Chemistry. 2014 (16): 3337–3340. doi:10.1002/ejoc.201402240. ISSN 1099-0690.
  3. Robert, Tobias; Velder, Janna; Schmalz, Hans-Günther (2008-09-22). "Enantioselective Cu-Catalyzed 1,4-Addition of Grignard Reagents to Cyclohexenone Using Taddol-Derived Phosphine-Phosphite Ligands and 2-Methyl-THF as a Solvent". Angewandte Chemie. 120 (40): 7832–7835. doi:10.1002/ange.200803247. ISSN 1521-3757.
  4. Romanski, Steffen; Kraus, Birgit; Schatzschneider, Ulrich; Neudörfl, Jörg-Martin; Amslinger, Sabine; Schmalz, Hans-Günther (2011-03-01). "Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)". Angewandte Chemie International Edition. 50 (10): 2392–2396. doi:10.1002/anie.201006598. ISSN 1521-3773.
  5. Zaminer, Jan; Brockmann, Christoph; Huy, Peter; Opitz, Robert; Reuter, Cédric; Beyermann, Michael; Freund, Christian; Müller, Matthias; Oschkinat, Hartmut (2010-09-17). "Addressing Protein-Protein Interactions with Small Molecules: A Pro-Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD-Binding Ligands". Angewandte Chemie International Edition. 49 (39): 7111–7115. doi:10.1002/anie.201001739. ISSN 1521-3773.


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