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John P Neoptolemos

From EverybodyWiki Bios & Wiki







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John P Neoptolemos
Born (1951-06-30) 30 June 1951 (age 73)
Pano Zodeia, Cyprus
🏳️ Citizenship England
🏫 EducationChurchill College, Cambridge, University of London, UCSD, University of Paris, University of Ulm
💼 Occupation
Known forEuropean Study Group for Pancreatic Cancer Research (ESPAC)
John P. Neoptolemos 2021

John P. Neoptolemos (born June 30, 1951) is a British surgeon and professor. He is a pancreas research specialist..[1][2][3] with over 75,000 scientific citations (h-index=127, in January 2022[4]), who has given numerous lectures at national and international scientific meetings. The specific areas of research of John Neoptolemos are therapies for pancreatic cancer[5][6][7], pre-symptomatic diagnosis, prognostic and biological predictors of treatment response to pancreatic cancer, clinical trials of pancreatic cancer[8][9][10], and acute, chronic, as well as hereditary pancreatitis. Neoptolemos was a British Department of Health Platinum Award holder from 2004[11], made a Fellow of the British Academy of Medical Sciences from 2007, a National Institute for Health Research (NIHR) Senior Fellow from 2011, and he was elected a Member of the Academia Europaea in 2019[12]. He is married to Linda Joan Blaylock, a mathematics teacher from Newcastle upon Tyne.

Early life and education[edit]

John Neoptolemos was born in Pano Zodhia, Cyprus, moved to London in 1955, and attended Stamford Hill Primary School and then Owen’s Grammar School for Boys, at the Angel, Islington in North London. He was an undergraduate at the University of Cambridge (Churchill College) where he studied (1970-1973) for a double degree in Natural Sciences and Philosophy at Cambridge. He undertook his clinical undergraduate training at Guy's Hospital, London (1973-1976). Following he completed his academic and clinical training in Leicester[13][14] under the tutelage of Professor Sir Peter Bell, being awarded a Doctorate in Medicine in 1986 for his thesis "Effect of surgery on monocyte function in patients with colorectal cancer"[15]. In 1981 Neoptolemos became a Fellow of the Royal College of Surgeons of England. In 1985 he spent a year in San Diego, California at UCSD with Professor Alan Hofmann. In San Diego he worked for Babs Moossa, an international hepato-pancreatobiliary surgeon. He later wrote Babs Moossa’s obituary for the Royal College of Surgeons.[16] His clinical education was completed following further surgical training with Professor Henri Bismuth in Paris and Professor Hans Beger in Ulm. There he met Markus Büchler, together setting up the European Study for Pancreas Cancer Research (ESPAC)[17] a few years later.

Career[edit]

University of Birmingham 1987 - 1996[edit]

In 1987 Neoptolemos was appointed Senior Lecturer in Surgery at the University of Birmingham, where he refined his clinical and research interests towards pancreatitis and pancreatic cancer. Initially he was at Dudley Road Hospital, later moving to the Queen Elizabeth Hospital. In 1990 he became a Reader and then in 1994 Professor of Surgery at the University of Birmingham.

University of Liverpool 1996 - 2017[edit]

In 1996 Neoptolemos was chosen as Chair of Surgery of Liverpool University and Head of Department of Surgery[18][19] to focus on pancreas disease research together with Professor Ole Petersen for the University[20][21], and to develop the surgical services of the Royal Liverpool University Hospital[22].

John Neoptolemos became the director of the newly established Liverpool Clinical Trial Unit (LCTU)[23] from 1996 and the chairman of the Pancreas Tumour Multi-Disciplinary Team at the Royal Liverpool University Hospital from 2001[24]. Neoptolemos and Petersen established the National Institutes of Health Research (NIHR) Pancreas Biomedical Research Unit from 2007, renewed again in 2012[22]. Neoptolemos was appointed head of the new Division of Surgery and Oncology, School of Clinical Sciences from 2004 until 2010. In 2005 he became head of the new School of Cancer Studies[25] comprising the three Divisions of Surgery, Oncology/ Hematology, and Pathology within the faculty of medicine. He developed the Cancer Strategy for the University of Liverpool, which was formally endorsed by University Council in 2005. The Strategy achieved to establish a Cancer Research UK (CRUK) Centre in Liverpool in 2008, to move the Clatterbridge Cancer Centre onto the Royal Liverpool University Hospital Site (opened in 2020), and so it created a modern comprehensive cancer centre[26] From 2007 he became the director of the Cancer Research UK Liverpool Cancer Trials Unit[27]. Neoptolemos was co-director of the CRUK and NIHR Liverpool Experimental Cancer Centre from 2007 until 2012 and from then the director of the LCTU GCP Labs as well as the director the CRUK from 2011 until 2013[28]. He was chairman of the Governance Board of the CRUK from 2009 until 2010. In 2012 the LCTU was successful in being awarded the North West Surgical Trials Centre awarded by the Royal College of Surgeons of England and Cancer Research UK. The Cancer Research UK Liverpool Centre received the Freedom of the City of Liverpool[29][30] on the 8th of February 2012. In 2014 the LCTU Cancer Research UK Liverpool Cancer Trials Unit received accreditation as National Cancer Research Institute (NCRI) Cancer Trials Unit[23]. The associated Pancreas Unit became the Health Services Journal National Award Winner in 2013[31]. Neoptolemos was appointed the Owen and Ellen Evans Chair of Cancer Studies from 2006 to 2010. He was a member of the University of Liverpool Trials Collaborative and the University of Liverpool Clinical Trials Oversight Committee from 2011 and a member of the Liverpool Health Partners Joint Research Office Oversight Committee also from 2011.

National and international scientific role[edit]

Neoptolemos has been the Clinical Lead for the development of the UK Clinical Guidelines for Pancreatic Cancer of the National Institute for Clinical Excellence (NICE). He was the Clinical Chair for the NICE Guidelines on Pancreatic Cancer (2015-2017)[32]. John Neoptolemos has been Secretary and President of the European Pancreas Club (EPC)[33], as well as President of the Pancreatic Society of Great Britain and Ireland[34] and the International Association of Pancreatology[35] (IAP)[36]. As IAP President he developed the first IAP Guidelines in 2003 – on acute pancreatitis[37]. More recently he has been involved in development series of the joint international consensus guidelines for chronic pancreatitis in collaboration with the IAP, the American Pancreatic Association (APA), the Japan Pancreas Society (JPS)[38], and the EPC[39][40][41][42][43][44][45][46]. Neoptolemos received international recognition including the Hirschberg Award for Pancreatic Cancer of the APA (2005); the Life Time Achievement Award of the EPC[47] (2013); the Ruth Brufsky Award for Pancreas Cancer Research[48] (2017); and the Henry Lynch Award for Inherited Pancreas Diseases[49] (2018).

Scientific merits[edit]

In 1989 Neoptolemos was the founder of the European Study for Pancreas Cancer Research (ESPAC)[50][51] that has led the way for internationally collaborative pancreas cancer trials[17][52][53][54][55]. In 1997 he established the European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC)[56][57], a resource and focus for the study of genetic pancreas diseases. In 2005 he co-founded the International Study Group for Pancreas Surgery (ISGPS) with Professors Claudio Bassi (Verona), Christos Dervenis (Athens) and Markus Büchler (Ulm)[58] He undertook the first trial comparing a surgery with an endoscopic interventional technique – this was for the treatment of bile duct stones.[59]. He was also the first to establish that early intervention (endoscopic sphincterotomy) could improve the outcome of severe acute pancreatitis[60]. In a key clinical study, he showed that trypsinogen activation was a very early event in human acute pancreatitis and that measurement of the levels of the trypsinogen activation peptide could predict the clinical outcome[61]. Most notably, the ESPAC-1 trial was the first definitive trial to establish the benefit of adjuvant treatment in pancreatic cancer favoring chemotherapy[52] rather than chemoradiotherapy[62][63][17]

Awards and honors (selection)[edit]

Books (selection)[edit]

  1. Neoptolemos JP (Ed). Cancer of the Pancreas.Clinical Gastroenterology, London, Baillière Tindall, Vol 4, No 4 1990, (pp 215)[1]
  2. Lemoine N, Cooke T, Neoptolemos JP (Eds). Cancer: A Molecular Approach. Oxford, Blackwell Scientific, 1993 (pp 383)[64]
  3. Neoptolemos JP, Lemoine N (Eds). Pancreatic Cancer: Molecular & Clinical Advances. Oxford, Blackwell Scientific 1996 (pp 346)[2]
  4. Beger HG, Warshaw A, Carr-Locke DL, Russell RCG, Buchler M, Neoptolemos JP, Saar M. (Eds). The Pancreas (Two Volumes). Boston, Blackwell Scientific 1998 (pp 1644)[65]
  5. Neoptolemos JP (Ed.). Acute Pancreatitis. Clinical Gastroenterology, London, Bailière Tindall 1999; Vol. 13, No. 2 (pp 152)[66]
  6. Gress TM, Neoptolemos JP, Lemoine NR, Real FX (Eds). Exocrine pancreas cancer. The European Pancreatic Cancer-Research Cooperative (PC-RC). Felsenstein CCCP, Hannover. 2005 (pp 531)[67]
  7. Neoptolemos JP and Bhutani MS. Fast Facts. Pancreas and Biliary Tree. Health Press Abingdon. 2006 (pp127)[68]
  8. Neoptolemos JP and Ghaneh P (Eds). Cancer of the Pancreas. Best Practice & Research in Clinical Gastroenterology. London, Baillière Tindall, 2006
  9. Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition. Blackwell Publishing, Massachusetts, USA, 2008 (pp 1006)[69]
  10. Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds). Pancreatic Cancer. Springer, New York, 2010. Two Volumes (pp1335)[70]
  11. HG Beger HG, Nakao A, Neoptolemos JP, Peng SY, Sarr MG (Eds). Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management.Wiley Blackwell Publishers. 2018 (pp 436)[71]
  12. Beger HG, Warshaw A, Hruban R, Büchler M, Lerch M, Neoptolemos JP, Tooru Shimosegawa, Whitcomb D. (Eds). The Pancreas, Third Edition. Blackwell Publishing, Massachusetts, USA, 2018 (pp 1173)[72]
  13. Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds). Pancreatic Cancer. Springer, New York. Second Edition. 2018. Three Volumes (pp 1642)[73][3].
  14. Beger HG, Warshaw A, Hruban R, Büchler M, Lerch M, Neoptolemos JP, Tooru Shimosegawa, Whitcomb D. (Eds). The Pancreas, Third Edition. The Pancreas: An Integrated Textbook of Basic Science. Chinese Edition. John Wiley & Sons Limited Chichester, West Sussex, United Kingdom. PO19 8SQ. ISBN 978-1-119-18839-1. 2019[72]

Sorted References (selection)[edit]

See PubMed for complete list of scientific articles.[74]

Early Interventional Randomized Clinical Trials and Acute Pancreatitis[edit]

  1. Neoptolemos JP, Carr-Locke DL, Fossard DP. Results of a prospective randomised study of pre-operative endoscopic sphincterotomy versus surgery alone for common bile duct stones. British Medical Journal 1987; 294:470-474[75]
  2. Neoptolemos JP, Carr-Locke DL, London NJM, Bailey I, James D, Fossard DP. Results of a prospective randomized trial of ERCP and endoscopic sphincterotomy in acute gallstone pancreatitis. Lancet 1988; ii: 979-983[76]
  3. Raraty M, Ward J, Sutton R, Neoptolemos JP, Petersen O. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences USA 2000; 97: 13126-13131[77]
  4. Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MGT, Slavin J, Beger H-G, Hiettaranta AJ, Puolakkainen PA. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet 2000; 355: 1955-1960[78]
  5. Pfützer RH, Barmada MM, Brunskil APJ, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb DC. SPINK1/PSTI Polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 2000; 119: 615-623[79]
  6. Gomatos IP, Halloran CM, Ghaneh P, Raraty MG, Polydoros F, Evans JC, Smart HL, Yagati-Satchidanand R, Garry JM, Whelan PA, Hughes FE, Sutton R, Neoptolemos JP. Outcomes From Minimal Access Retroperitoneal and Open Pancreatic Necrosectomy in 394 Patients With Necrotizing Pancreatitis. Ann Surg. 2016 May;263(5):992-1001[80]

EUROPAC[edit]

  1. Threadgold J, Greenhalf W, Ellis I, Howes N, Lerch MM, Jansen J, Charnley R, Laugier R, Frulloni L, Attila GO, Delhaye M, Ihse I, Schaffalitzky de Muchadell OB, Andrén-Sandberg Å, Imrie CW, Martinek J, Gress TM, Mountford R, Whitcomb D, Neoptolemos JP. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. Gut 2002; 50: 675-681[81]
  2. Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP; European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC). Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clinical Gastroenterology and Hepatology 2004; 2(3):252–261[82]
  3. McFaul CD, Greenhalf W, Earl J, Howes N, Neoptolemos JP for the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC), Kress R, Sina-Frey M, Rieder H, Hahn SA, Bartsch DK, for the German national Case Collection for Familial Pancreatic Cancer (FaPaCa). Anticipation in familial pancreatic cancer. Gut 2006; 55:252-258[83]
  4. Grocock CJ, Rebours V, Delhaye M, Andren-Sandberg A, Weiss FU, Mountford R, Harcus M, Niemczyck E, Vitone L, Dodd S, Joergensen MT, Ammann RW, Schaffalitzky de Muckadell O, Butler JV, Burgess P, Kerr B, Charnley R, Sutton R, Raraty M, Deviere J, Whitcomb D, Neoptolemos J, Levy P, Lerch MM, Greenhalf W. The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families. Gut 2010; 59: 357-63[84]

ESPAC Trials[edit]

  1. Neoptolemos JP, Dunn JA, Moffitt DD, Almond J, Link K, Beger H, Bassi C, Falconi M, Pederzoli P, Dervenis C, Fernandez-Cruz, Lacaine F, Pap A, Spooner D, Kerr DJ, Friess H and Büchler M, for the members of the European Study Group for Pancreatic Cancer (ESPAC). ESPAC-1: A European, Randomized Controlled Study of Adjuvant Chemoradiation and Chemotherapy in Resectable Pancreatic Cancer. Lancet 2001; 358: 1576-85[85]
  2. Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, Beger H, Fernandez-Cruz L, Dervenis C, Lacaine F, Falconi M, Pederzoli P, Pap A, Spooner D, Kerr DJ, Büchler MW for the members of the European Study Group for Pancreatic Cancer (ESPAC). A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. New England Journal of Medicine 2004; 350(12):1200-1210.
  3. Carter R, Stocken DD, Ghaneh P, Bramhall SR, Olah A, Kelemen D, Bassi C, Friess H, Dervenis C, Spry N, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer (ESPAC). Longitudinal quality of life data can provide insights on the impact of adjuvant treatment for pancreatic cancer-Subset analysis of the ESPAC-1 data. Int J Cancer. 2009 Jun 15;124(12):2960-5[86]
  4. Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, Padbury R, Moore MJ, Gallinger S, Mariette C, Wente MN, Izbicki JR, Friess H, Lerch MM, Dervenis C, Oláh A, Butturini G, Doi R, Lind PA, Smith D, Valle JW, Palmer DH, Buckels JA, Thompson J, McKay CJ, Rawcliffe CL, Büchler MW; European Study Group for Pancreatic Cancer. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010; 304(10): 1073-81[87]
  5. Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer.Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma. The ESPAC-3 Periampullary Cancer Randomized Trial. JAMA. 2012;308(2):147-56.[88]
  6. Greenhalf W, Ghaneh P, Neoptolemos JP, Palmer DH, Cox TF, Lamb RF, Garner E, Campbell F, Mackey JR, Costello E, Moore MJ, Valle JW, McDonald AC, Carter R, Tebbutt NC, Goldstein D, Shannon J, Dervenis C, Glimelius B, Deakin M, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Halloran CM, Mayerle J, Oláh A, Jackson R, Rawcliffe CL, Scarpa A, Bassi C, Büchler MW; European Study Group for Pancreatic Cancer. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. J Natl Cancer Inst. 2014 Jan;106(1):djt347[89]
  7. Valle JW, Palmer D, Jackson R, Cox T, Neoptolemos JP, Ghaneh P, Rawcliffe CL, Bassi C, Stocken DD, Cunningham D, O'Reilly D, Goldstein D, Robinson BA, Karapetis C, Scarfe A, Lacaine F, Sand J, Izbicki JR, Mayerle J, Dervenis C, Oláh A, Butturini G, Lind PA, Middleton MR, Anthoney A, Sumpter K, Carter R, Büchler MW. Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study. Journal of Clinical Oncology. 2014; 32:504-512[90]
  8. Kleeff J, Costello E, Jackson R, Halloran C, Greenhalf W, Ghaneh P, Lamb RF, Lerch MM, Mayerle J, Palmer D, Cox T, Rawcliffe CL, Strobel O, Büchler MW, Neoptolemos JP. The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer. Br J Cancer. 2016 Sep 27;115(7):887-94[91]
  9. Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, Darby S, Meyer T, Gillmore R, Anthoney A, Lind P, Glimelius B, Falk S, Izbicki JR, Middleton GW, Cummins S, Ross PJ, Wasan H, McDonald A, Crosby T, Ma YT, Patel K, Sherriff D, Soomal R, Borg D, Sothi S, Hammel P, Hackert T, Jackson R, Büchler MW; European Study Group for Pancreatic Cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017 Mar 11;389(10073):1011-1024[92]
  10. Ghaneh P, Kleeff J, Halloran CM, Raraty M, Jackson R, Melling J, Jones O, Palmer DH, Cox TF, Smith CJ, O'Reilly DA, Izbicki JR, Scarfe AG, Valle JW, McDonald AC, Carter R, Tebbutt NC, Goldstein D, Padbury R, Shannon J, Dervenis C, Glimelius B, Deakin M, Anthoney A, Lerch MM, Mayerle J, Oláh A, Rawcliffe CL, Campbell F, Strobel O, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer. The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma. Ann Surg. 2019 Mar;269(3):520-529[93]
  11. Jones RP, Psarelli EE, Jackson R, Ghaneh P, Halloran CM, Palmer DH, Campbell F, Valle JW, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, Darby S, Meyer T, Gillmore R, Anthoney A, Lind P, Glimelius B, Falk S, Izbicki JR, Middleton GW, Cummins S, Ross PJ, Wasan H, McDonald A, Crosby T, Ting Y, Patel K, Sherriff D, Soomal R, Borg D, Sothi S, Hammel P, Lerch MM, Mayerle J, Tjaden C, Strobel O, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer. Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial. JAMA Surg. 2019 Nov 1;154(11):1038-1048[94]

ISGPS[edit]

  1. Bassi C, Butturini G, Fingerhut A, Yeo C, Izibicki J, Neoptolemos JP, Sarr M, Traverso W, Buchler M, Dervenis C for the International Study Group on Pancreatic Fistula Definition. Post-operative pancreatic fistula: an International Study Group (ISGPF) definition. Surgery 2005;138(1): 8-13[95]
  2. Wente MN, Claudio Bassi, Christos Dervenis, Fingerhut A, Gouma DJ, Izbicki JR, Neoptolemos JP, Padbury RT, Sarr MG, Traverso LW, Yeo, CJ, Büchler MW.Delayed gastric emptying after pancreatic surgery – A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 2007;142(5):761-8[96]
  3. Wente MN, Veit JA,Claudio Bassi, Christos Dervenis, Fingerhut A, Gouma DJ, Izbicki JR, Neoptolemos JP, Padbury RT, Sarr MG, Traverso LW, Yeo, CJ, Büchler MW. Postpancreatectomy hemorrhage (PPH) – An International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 2007;142(1):20-5[97]
  4. Shukla PJ, Barreto SG, Fingerhut A, Bassi C, Büchler MW, Dervenis C, Gouma D, Izbicki JR, Neoptolemos J, Padbury R, Sarr MG, Traverso W, Yeo CJ, Wente MN. Toward improving uniformity and standardization in the reporting of pancreatic anastomoses: a new classification system by the International Study Group of Pancreatic Surgery (ISGPS).Surgery. 2010;147(1):144-53[98]
  5. Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, Andrén-Sandberg A, Asbun HJ, Bassi C, Bockhorn M, Charnley R, Conlon KC, Dervenis C, Fernandez-Cruz L, Friess H, Gouma DJ, Imrie CW, Lillemoe KD, Milićević MN, Montorsi M, Shrikhande SV, Vashist YK, Izbicki JR, Büchler MW; International Study Group on Pancreatic Surgery. Extended pancreatectomy in pancreatic ductal adenocarcinoma: Definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery. 2014; 156(1):1-14[99]
  6. Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR; International Study Group of Pancreatic Surgery. Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2014;155(6):977-88[100]
  7. Tol JA, Gouma DJ, Bassi C, Dervenis C, Montorsi M, Adham M, Andrén-Sandberg A, Asbun HJ, Bockhorn M, Büchler MW, Conlon KC, Fernández-Cruz L, Fingerhut A, Friess H, Hartwig W, Izbicki JR, Lillemoe KD, Milicevic MN, Neoptolemos JP, Shrikhande SV, Vollmer CM, Yeo CJ, Charnley RM; International Study Group on Pancreatic Surgery. Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery. 2014; 156(3):591-600[101]
  8. Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adam M, Allen P, Andersson R, Asbun HJ, Besselink MG, Conlon K, Del Chiaro M, Falconi M, Fernandez-Cruz L, Fernandez-Del Castillo C, Fingerhut A, Friess H, Gouma DJ, Hackert T, Izbicki J, Lillemoe KD, Neoptolemos JP, Olah A, Schulick R, Shrikhande SV, Takada T, Takaori K, Traverso W, Vollmer CR, Wolfgang CL, Yeo CJ, Salvia R, Buchler M; International Study Group on Pancreatic Surgery (ISGPS). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery. 2017 Mar;161(3):584-591[102]
  9. Shrikhande SV, Sivasanker M, Vollmer CM, Friess H, Besselink MG, Fingerhut A, Yeo CJ, Fernandez-delCastillo C, Dervenis C, Halloran C, Gouma DJ, Radenkovic D, Asbun HJ, Neoptolemos JP, Izbicki JR, Lillemoe KD, Conlon KC, Fernandez-Cruz L, Montorsi M, Bockhorn M, Adham M, Charnley R, Carter R, Hackert T, Hartwig W, Miao Y, Sarr M, Bassi C, Büchler MW; International Study Group of Pancreatic Surgery (ISGPS). Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2017 May; 161(5):1221-1234[103]
  10. Siriwardena AK, Windsor J, Zyromski N, Marchegiani G, Radenkovic D, Morgan C, Passas I, Olah A, Conlon KC, Smith M, Busch O, Baltatzis M, Besselink MG, Vollmer C, Castillo CF, Friess H, Garcea G, Burmeister S, Hackert T, Lillemoe KD, Schulick R, Shrikhande SV, Smith A, Gianotti L, Falconi M, Adams D, Adham M, Andersson R, Del Chiaro M, Devar J, Jegatheeswaran S, van Santvoort H, Khatkov I, Izbicki J, Büchler M, Neoptolemos JP, Bassi C, Dervenis C. Standards for reporting on surgery for chronic pancreatitis: a report from the International Study Group for Pancreatic Surgery (ISGPS). Surgery. 2020; 168: 101-105[104]
  11. Miao Y, Lu Z, Yeo CJ, Vollmer CM Jr, Fernandez-Del Castillo C, Ghaneh P, Halloran CM, Kleeff J, de Rooij T, Werner J, Falconi M, Friess H, Zeh HJ, Izbicki JR, He J, Laukkarinen J, Dejong CH, Lillemoe KD, Conlon K, Takaori K, Gianotti L, Besselink MG, Del Chiaro M, Montorsi M, Tanaka M, Bockhorn M, Adham M, Oláh A, Salvia R, Shrikhande SV, Hackert T, Shimosegawa T, Zureikat AH, Ceyhan GO, Peng Y, Wang G, Huang X, Dervenis C, Bassi C, Neoptolemos JP, Büchler MW; International Study Group of Pancreatic Surgery (ISGPS). Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS). Surgery[105]

References[edit]

  1. ↑ "Patrick Swayze: "miracle dude"". The Sydney Morning Herald. 2008-07-23. Retrieved 2022-03-11.
  2. ↑ "Apple's Steve Jobs to take medical leave". the Guardian. 2011-01-17. Retrieved 2022-03-11.
  3. ↑ "Manchester University deaths 'not linked to radiation'". BBC News. 2013-01-10. Retrieved 2022-03-11.
  4. ↑ "John Neoptolemos". scholar.google.com. Retrieved 2022-01-27.
  5. ↑ "New pancreatic cancer hope". 2001-11-10. Retrieved 2022-03-11.
  6. ↑ "'Major win' in pancreatic cancer fight". BBC News. 2016-06-03. Retrieved 2022-03-11.
  7. ↑ "Fight against pancreatic cancer takes 'monumental leap forward'". The Independent. 2017-01-25. Retrieved 2022-03-11.
  8. ↑ "Drug combination may extend pancreas cancer survival, trial finds". the Guardian. 2016-06-03. Retrieved 2022-03-11.
  9. ↑ "Study establishes new standard of care for pancreatic cancer patients". Cancer Research UK - Cancer News. 2017-01-25. Retrieved 2022-03-01.
  10. ↑ "Trial finds combination of pancreatic cancer drugs extends survival". the Guardian. 2017-01-25. Retrieved 2022-03-11.
  11. ↑ "Nominal roll of consultant awards in England and Wales: 2017". GOV.UK. Retrieved 2022-03-11.
  12. ↑ 12.0 12.1 "Academia Europea Members".
  13. ↑ Neoptolemos, John P.; Heagerty, A. M.; Nicholson, M.; James, R. F. L.; Clayton, H.; Bell, P. R. F. (1987). "Inadequacy Of Oleic Acid In Erythrocytes As A Marker Of Malignancies". British Medical Journal (Clinical Research Edition). 294 (6580): 1157–1158. ISSN 0267-0623. JSTOR 29526898.
  14. ↑ Neoptolemos, John P.; Lloyd, David M.; Carr-Locke, David L. (1984). "Diagnosing Gall Bladder Disease". British Medical Journal (Clinical Research Edition). 289 (6437): 108. ISSN 0267-0623. JSTOR 29515843.
  15. ↑ Neoptolemos, JP; Wood, P; Everson, NW; Bell, PR (September 1986). "The effect of surgical procedures on monocyte function in patients with carcinoma of the colon and rectum". Surgery, Gynecology & Obstetrics. 163 (3): 235–42. PMID 3750179.
  16. ↑ "Moossa, Abdool Rahim Orbituary". RCS.
  17. ↑ 17.0 17.1 17.2 Neoptolemos, J. P.; Dunn, J. A.; Stocken, D. D.; Almond, J.; Link, K.; Beger, H.; Bassi, C.; Falconi, M.; Pederzoli, P.; Dervenis, C.; Fernandez-Cruz, L.; Lacaine, F.; Pap, A.; Spooner, D.; Kerr, D. J.; Friess, H.; Büchler, M. W. (10 November 2001). "Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial". The Lancet. 358 (9293): 1576–1585. doi:10.1016/S0140-6736(01)06651-X. PMID 11716884. Unknown parameter |s2cid= ignored (help)
  18. ↑ West, P. A.; Parsons, Keith; Evans, Susan; Laurence, Mike; McKenzie, Kwame; Jakeman, Nicola; Gregson, P. N.; Stewart, Andy; Seddon, David; Smith, Simon; Hart, Julian Tudor (2001). "Why Are Doctors So Unhappy?". BMJ: British Medical Journal. 322 (7298): 1361–1365. doi:10.1136/bmj.322.7298.1361. ISSN 0959-8138. JSTOR 25467075. PMC 1120436. PMID 11407364.
  19. ↑ O'Connor, Anahad (2002-07-29). "Bertram D. Cohn, 76, Surgeon Who Created Embolism Filter". The New York Times. ISSN 0362-4331. Retrieved 2022-03-11.
  20. ↑ Raraty, Michael; Ward, Jeremy; Erdemli, Gul; Vaillant, Camille; Neoptolemos, John P.; Sutton, Robert; Petersen, Ole H. (2000). "Calcium-Dependent Enzyme Activation and Vacuole Formation in the Apical Granular Region of Pancreatic Acinar Cells". Proceedings of the National Academy of Sciences of the United States of America. 97 (24): 13126–13131. Bibcode:2000PNAS...9713126R. doi:10.1073/pnas.97.24.13126. ISSN 0027-8424. JSTOR 123666. PMC 27189. PMID 11087863.
  21. ↑ Criddle, David N.; Raraty, Michael G. T.; Neoptolemos, John P.; Tepikin, Alexei V.; Petersen, Ole H.; Sutton, Robert; Burgen, Arnold S. (2004). "Ethanol Toxicity in Pancreatic Acinar Cells: Mediation by Nonoxidative Fatty Acid Metabolites". Proceedings of the National Academy of Sciences of the United States of America. 101 (29): 10738–10743. Bibcode:2004PNAS..10110738C. doi:10.1073/pnas.0403431101. ISSN 0027-8424. JSTOR 3372729. PMC 490004. PMID 15247419.
  22. ↑ 22.0 22.1 McIntyre-Brown, Arabella (2001). Liverpool : the first 1,000 years. Guy Woodland. Liverpool, England: Garlic Press. ISBN 1-904099-00-9. OCLC 318282497. Search this book on
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  24. ↑ "Professor John Neoptolemos". Cancer Research UK. 2017-03-09. Retrieved 2022-03-01.
  25. ↑ "Pancreatic cancer vaccine on trial". BBC News. Retrieved 2022-03-11.
  26. ↑ "Cancer Research UK Centre opens in Liverpool - University of Liverpool News". News. 2009-02-25. Retrieved 2022-01-27.
  27. ↑ "New approach could improve survival time for pancreatic cancer patients - University of Liverpool News". News. 2017-01-25. Retrieved 2022-03-01.
  28. ↑ "KEY CANCER VACCINE TRIAL BEGINS IN CITY. - Free Online Library". www.thefreelibrary.com. Retrieved 2022-03-11.
  29. ↑ "Cancer centre given Freedom of the City of Liverpool". BBC. 8 February 2012.
  30. ↑ 30.0 30.1 "Cancer Research UK Centre receives Freedom of the City". University of Liverpool News. 13 February 2012. Retrieved 13 December 2021.
  31. ↑ 2013-11-19T23:00:00+00:00. "HSJ Awards 2013 winners announced". Health Service Journal. Retrieved 2022-01-27.
  32. ↑ "Professor appointed national Clinical Chair for Pancreatic Cancer - University of Liverpool News". News. 2015-12-02. Retrieved 2022-01-27.
  33. ↑ "Professor elected President of the European Pancreatic Club". University of Liverpool. 17 June 2016. Retrieved 13 December 2021.
  34. ↑ "PSGBI Committee". Pancreatic Society of Great Britain and Ireland. Retrieved 13 December 2021.
  35. ↑ "IAP Presidents". International Association of Pancreatology. Retrieved 13 December 2021.
  36. ↑ Goebell, Harald; Ammann, Rudolf; Creutzfeldt, Werner (May 2005). "History of the European Pancreatic Club: The First 40 Years 1965-2005". Pancreatology. 5 (1): 1–15. doi:10.1159/000086210. PMID 15942268. Unknown parameter |s2cid= ignored (help)
  37. ↑ Uhl, Waldemar; Warshaw, Andrew; Imrie, Clement; Bassi, Claudio; McKay, Colin J.; Lankisch, Paul G.; Carter, Ross; Magno, Eugene Di; Banks, Peter A.; Whitcomb, David C.; Dervenis, Christos (January 2002). "IAP Guidelines for the surgical management of acute pancreatitis". Pancreatology. 2 (6): 565–573. doi:10.1159/000067684. PMID 12435871.
  38. ↑ Whitcomb, David C.; Shimosegawa, Tooru; Chari, Suresh T.; Forsmark, Christopher E.; Frulloni, Luca; Garg, Pramod; Hegyi, Peter; Hirooka, Yoshiki; Irisawa, Atsushi; Ishikawa, Takuya; Isaji, Shuiji (July 2018). "International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club". Pancreatology. 18 (5): 516–527. doi:10.1016/j.pan.2018.05.008. PMC 6748871 Check |pmc= value (help). PMID 29793839.
  39. ↑ Frøkjær, Jens Brøndum; Akisik, Fatih; Farooq, Ammad; Akpinar, Burcu; Dasyam, Anil; Drewes, Asbjørn Mohr; Haldorsen, Ingfrid S.; Morana, Giovanni; Neoptolemos, John P.; Olesen, Søren Schou; Petrone, Maria Chiara (October 2018). "Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis". Pancreatology. 18 (7): 764–773. doi:10.1016/j.pan.2018.08.012. PMID 30177434. Unknown parameter |s2cid= ignored (help)
  40. ↑ Kempeneers, M.A.; Issa, Y.; Ali, U. Ahmed; Baron, R.D.; Besselink, M.G.; Büchler, M.; Erkan, M.; Fernandez-Del Castillo, C.; Isaji, S.; Izbicki, J.; Kleeff, J. (March 2020). "International consensus guidelines for surgery and the timing of intervention in chronic pancreatitis". Pancreatology. 20 (2): 149–157. doi:10.1016/j.pan.2019.12.005. PMID 31870802. Unknown parameter |s2cid= ignored (help)
  41. ↑ Abu-El-Haija, Maisam; Anazawa, Takayuki; Beilman, Gregory J.; Besselink, Marc G.; Del Chiaro, Marco; Demir, Ihsan Ekin; Dennison, Ashley R.; Dudeja, Vikas; Freeman, Martin L.; Friess, Helmut; Hackert, Thilo (June 2020). "The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis". Pancreatology. 20 (4): 762–771. doi:10.1016/j.pan.2020.04.005. PMID 32327370 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  42. ↑ Hegyi, Péter; Párniczky, Andrea; Lerch, Markus M.; Sheel, Andrea R.G.; Rebours, Vinciane; Forsmark, Chris E.; Del Chiaro, Marco; Rosendahl, Jonas; de-Madaria, Enrique; Szücs, Ákos; Takaori, Kyoichi (June 2020). "International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club". Pancreatology. 20 (4): 579–585. doi:10.1016/j.pan.2020.03.014. PMID 32376198 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  43. ↑ Esposito, Irene; Hruban, Ralph H.; Verbeke, Caroline; Terris, Benoit; Zamboni, Giuseppe; Scarpa, Aldo; Morohoshi, Toshio; Suda, Koichi; Luchini, Claudio; Klimstra, David S.; Adsay, Volkan (June 2020). "Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club". Pancreatology. 20 (4): 586–593. doi:10.1016/j.pan.2020.04.009. PMID 32414657 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  44. ↑ Mel Wilcox, C.; Gress, Thomas; Boermeester, Marja; Masamune, Atsushi; Lévy, Philippe; Itoi, Takao; Varadarajulu, Shyam; Irisawa, Atsushi; Levy, Michael; Kitano, Masayuki; Garg, Pramod (July 2020). "International consensus guidelines on the role of diagnostic endoscopic ultrasound in the management of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club". Pancreatology. 20 (5): 822–827. doi:10.1016/j.pan.2020.05.025. PMID 32631791 Check |pmid= value (help).
  45. ↑ Kitano, Masayuki; Gress, Thomas M.; Garg, Pramod K.; Itoi, Takao; Irisawa, Atsushi; Isayama, Hiroyuki; Kanno, Atsushi; Takase, Kei; Levy, Michael; Yasuda, Ichiro; Lévy, Phillipe (September 2020). "International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club". Pancreatology. 20 (6): 1045–1055. doi:10.1016/j.pan.2020.05.022. PMID 32792253 Check |pmid= value (help).
  46. ↑ Drewes, Asbjørn M.; Campbell, Claudia M.; Ceyhan, Güralp O.; Delhaye, Myriam; Garg, Pramod K.; van Goor, Harry; Laquente, Berta; Morlion, Bart; Olesen, Søren S.; Singh, Vikesh K.; Sjøgren, Per (June 2018). "Pain in pancreatic ductal adenocarcinoma: A multidisciplinary, International guideline for optimized management". Pancreatology. 18 (4): 446–457. doi:10.1016/j.pan.2018.04.008. PMID 29706482. Unknown parameter |s2cid= ignored (help)
  47. ↑ 47.0 47.1 "Professor John Neoptolemos receives lifetime achievement award". University of Liverpool School of Life Sciences. 16 July 2013. Retrieved 13 December 2021.
  48. ↑ 48.0 48.1 "PancreasFest 2017" (PDF). Division of Gastroenterology, Hepatology and Nutrition University of Pittsburgh. Retrieved 13 December 2021.
  49. ↑ 49.0 49.1 "European Pancreas Club Jubilee Meeting 2018" (PDF). Retrieved 13 December 2021.
  50. ↑ "Mix of pancreatic cancer drugs extends survival, study shows". The Irish Times. Retrieved 2022-03-11.
  51. ↑ Ärzteblatt, Deutscher Ärzteverlag GmbH, Redaktion Deutsches (2017-01-26). "Pankreaskarzinom: Capecitabin plus Gemcitabin verlängern Überleben". Deutsches Aerzteblatt (in Deutsch). Retrieved 2022-03-01.
  52. ↑ 52.0 52.1 Neoptolemos, John P.; Stocken, Deborah D.; Friess, Helmut; Bassi, Claudio; Dunn, Janet A.; Hickey, Helen; Beger, Hans; Fernandez-Cruz, Laureano; Dervenis, Christos; Lacaine, François; Falconi, Massimo; Pederzoli, Paolo; Pap, Akos; Spooner, David; Kerr, David J.; Büchler, Markus W. (18 March 2004). "A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer". New England Journal of Medicine. 350 (12): 1200–1210. doi:10.1056/NEJMoa032295. PMID 15028824.
  53. ↑ Neoptolemos, John P.; Stocken, Deborah D.; Bassi, Claudio; Ghaneh, Paula; Cunningham, David; Goldstein, David; Padbury, Robert; Moore, Malcolm J.; Gallinger, Steven; Mariette, Christophe; Wente, Moritz N.; Izbicki, Jakob R.; Friess, Helmut; Lerch, Markus M.; Dervenis, Christos; Oláh, Attila; Butturini, Giovanni; Doi, Ryuichiro; Lind, Pehr A.; Smith, David; Valle, Juan W.; Palmer, Daniel H.; Buckels, John A.; Thompson, Joyce; McKay, Colin J.; Rawcliffe, Charlotte L.; Büchler, Markus W.; European Study Group for Pancreatic Cancer, for the (8 September 2010). "Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection: A Randomized Controlled Trial". JAMA. 304 (10): 1073–1081. doi:10.1001/jama.2010.1275. PMID 20823433.
  54. ↑ Neoptolemos, John P.; Moore, Malcolm J.; Cox, Trevor F.; Valle, Juan W.; Palmer, Daniel H.; McDonald, Alexander C.; Carter, Ross; Tebbutt, Niall C.; Dervenis, Christos; Smith, David; Glimelius, Bengt; Charnley, Richard M.; Lacaine, François; Scarfe, Andrew G.; Middleton, Mark R.; Anthoney, Alan; Ghaneh, Paula; Halloran, Christopher M.; Lerch, Markus M.; Oláh, Attila; Rawcliffe, Charlotte L.; Verbeke, Caroline S.; Campbell, Fiona; Büchler, Markus W.; European Study Group for Pancreatic Cancer, for the (11 July 2012). "Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma: The ESPAC-3 Periampullary Cancer Randomized Trial". JAMA. 308 (2): 147–156. doi:10.1001/jama.2012.7352. PMID 22782416.
  55. ↑ Neoptolemos, John P; Palmer, Daniel H; Ghaneh, Paula; Psarelli, Eftychia E; Valle, Juan W; Halloran, Christopher M; Faluyi, Olusola; O'Reilly, Derek A; Cunningham, David; Wadsley, Jonathan; Darby, Suzanne; Meyer, Tim; Gillmore, Roopinder; Anthoney, Alan; Lind, Pehr; Glimelius, Bengt; Falk, Stephen; Izbicki, Jakob R; Middleton, Gary William; Cummins, Sebastian; Ross, Paul J; Wasan, Harpreet; McDonald, Alec; Crosby, Tom; Ma, Yuk Ting; Patel, Kinnari; Sherriff, David; Soomal, Rubin; Borg, David; Sothi, Sharmila; Hammel, Pascal; Hackert, Thilo; Jackson, Richard; Büchler, Markus W (March 2017). "Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial". The Lancet. 389 (10073): 1011–1024. doi:10.1016/S0140-6736(16)32409-6. PMID 28129987. Unknown parameter |s2cid= ignored (help)
  56. ↑ Finch, Margaret D.; Howes, Nathan; Ellis, Ian; Mountford, Roger; Sutton, Robert; Raraty, Michael; Neoptolemos, John P. (1997). "Hereditary Pancreatitis and Familial Pancreatic Cancer". Digestion. 58 (6): 564–569. doi:10.1159/000201502. PMID 9438603.
  57. ↑ Gong, Yuanfeng; Zhou, Quanbo; Zhou, Yu; Lin, Qing; Zeng, Bing; Chen, Rufu; Li, Zhihua (2012). "Gastrectomy and risk of pancreatic cancer: systematic review and meta-analysis of observational studies". Cancer Causes & Control. 23 (8): 1279–1288. doi:10.1007/s10552-012-0005-z. ISSN 0957-5243. JSTOR 23255042. PMID 22674223. Unknown parameter |s2cid= ignored (help)
  58. ↑ Bassi, Claudio; Dervenis, Christos; Butturini, Giovanni; Fingerhut, Abe; Yeo, Charles; Izbicki, Jakob; Neoptolemos, John; Sarr, Michael; Traverso, William; Buchler, Marcus (July 2005). "Postoperative pancreatic fistula: An international study group (ISGPF) definition". Surgery. 138 (1): 8–13. doi:10.1016/j.surg.2005.05.001. PMID 16003309.
  59. ↑ Neoptolemos, J P; Carr-Locke, D L; Fossard, D P (21 February 1987). "Prospective randomised study of preoperative endoscopic sphincterotomy versus surgery alone for common bile duct stones". BMJ. 294 (6570): 470–474. doi:10.1136/bmj.294.6570.470. PMC 1245519. PMID 3103731.
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  61. ↑ Neoptolemos, J. P.; Kemppainen, E. A.; Mayer, J. M.; Fitzpatrick, J. M.; Raraty, M. G. T.; Slavin, J.; Beger, H.-G.; Hietaranta, A. J.; Puolakkainen, P. A. (3 June 2000). "Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study". The Lancet. 355 (9219): 1955–1960. doi:10.1016/S0140-6736(00)02327-8. PMID 10859041. Unknown parameter |s2cid= ignored (help)
  62. ↑ Gottlieb, Scott (2004). "Resectable pancreatic cancer needs surgery, then chemotherapy". BMJ: British Medical Journal. 328 (7441): 661. doi:10.1136/bmj.328.7441.661-a. ISSN 0959-8138. JSTOR 41707160. PMC 381249.
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  65. ↑ The pancreas. H. G. Beger. Oxford: Blackwell Science. 1998. ISBN 0-86542-420-9. OCLC 36352744. Search this book on
  66. ↑ Neoptolemos, John P (1999). Acute Pancreatitis, Bailliere's best practice & research. Clinical gastroenterology. London: Bailliere Tindall. p. 152. Search this book on
  67. ↑ Exocrine pancreas cancer the European Pancreatic Cancer-Research Cooperative (EPC-RC). Thomas Mathias Gress. Hannover. 2005. ISBN 978-3-00-016372-2. OCLC 181519963. Search this book on
  68. ↑ Neoptolemos, John P. (2006). Diseases of the pancreas and biliary tract. Manoop S. Bhutani. Abingdon: Health Press. ISBN 978-1-905832-22-4. OCLC 746746637. Search this book on
  69. ↑ The pancreas : an integrated textbook of basic science, medicine, and surgery. H. G. Beger (2 ed.). Malden, Mass.: Blackwell Pub. 2008. ISBN 978-1-4443-0012-3. OCLC 352835994. Search this book on
  70. ↑ Pancreatic cancer. John Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus Büchler (1 ed.). New York, NY. 2018. ISBN 978-1-4939-7193-0. OCLC 1031374838. Search this book on
  71. ↑ Pancreatic cancer, cystic neoplasms and endocrine tumors : diagnosis and management. H. G. Beger, Akimasa Nakao, John Neoptolemos, Shu You Peng, Michael G. Sarr. Chichester, West Sussex. 2016. ISBN 978-1-118-30783-0. OCLC 898433581. Search this book on
  72. ↑ 72.0 72.1 The pancreas : an integrated textbook of basic science, medicine, and surgery. H. G. Beger (3 ed.). Hoboken, NJ. 2018. ISBN 978-1-119-18841-4. OCLC 1065547789. Search this book on
  73. ↑ Pancreatic cancer. John Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus Büchler (2 ed.). New York, NY. 2018. ISBN 978-1-4939-7193-0. OCLC 1031374838. Search this book on
  74. ↑ Search Results for author Neoptolemos J on PubMed.
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  76. ↑ Neoptolemos, J.P.; London, N.J.; James, D.; Carr-Locke, D.L.; Bailey, I.A.; Fossard, D.P. (October 1988). "Controlled Trial of Urgent Endoscopic Retrograde Cholangiopancreatography and Endoscopic Sphincterotomy Versus Conservative Treatment for Acute Pancreatitis Due to Gallstones". The Lancet. 332 (8618): 979–983. doi:10.1016/S0140-6736(88)90740-4. PMID 2902491. Unknown parameter |s2cid= ignored (help)
  77. ↑ Raraty, Michael; Ward, Jeremy; Erdemli, Gul; Vaillant, Camille; Neoptolemos, John P.; Sutton, Robert; Petersen, Ole H. (2000-11-21). "Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells". Proceedings of the National Academy of Sciences. 97 (24): 13126–13131. Bibcode:2000PNAS...9713126R. doi:10.1073/pnas.97.24.13126. ISSN 0027-8424. PMC 27189. PMID 11087863.
  78. ↑ Neoptolemos, JP; Kemppainen, EA; Mayer, JM; Fitzpatrick, JM; Raraty, MGT; Slavin, J; Beger, H-G; Hietaranta, AJ; Puolakkainen, PA (June 2000). "Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study". The Lancet. 355 (9219): 1955–1960. doi:10.1016/s0140-6736(00)02327-8. ISSN 0140-6736. PMID 10859041. Unknown parameter |s2cid= ignored (help)
  79. ↑ Pfützer, Roland H.; Barmada, M.Michael; Brunskill, Andrew P.J.; Finch, Robert; Hart, P.Suzanne; Neoptolemos, John; Furey, William F.; Whitcomb, David C. (September 2000). "SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis". Gastroenterology. 119 (3): 615–623. doi:10.1053/gast.2000.18017. ISSN 0016-5085. PMID 10982753.
  80. ↑ Gomatos, Ilias P.; Halloran, Christopher M.; Ghaneh, Paula; Raraty, Michael G.T.; Polydoros, Fotis; Evans, Jonathan C.; Smart, Howard L.; Yagati-Satchidanand, R.; Garry, Jo M.; Whelan, Philip A.; Hughes, Faye E. (May 2016). "Outcomes From Minimal Access Retroperitoneal and Open Pancreatic Necrosectomy in 394 Patients With Necrotizing Pancreatitis". Annals of Surgery. 263 (5): 992–1001. doi:10.1097/sla.0000000000001407. ISSN 0003-4932. PMID 26501713. Unknown parameter |s2cid= ignored (help)
  81. ↑ Threadgold, J (2002-05-01). "The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease". Gut. 50 (5): 675–681. doi:10.1136/gut.50.5.675. ISSN 0017-5749. PMC 1773194. PMID 11950815.
  82. ↑ Howes, Nathan; Lerch, Markus M.; Greenhalf, William; Stocken, Deborah D.; Ellis, Ian; Simon, Peter; Truninger, Kaspar; Ammann, Rudi; Cavallini, Giorgio; Charnley, Richard M.; Uomo, Generoso (March 2004). "Clinical and genetic characteristics of hereditary pancreatitis in Europe". Clinical Gastroenterology and Hepatology. 2 (3): 252–261. doi:10.1016/s1542-3565(04)00013-8. ISSN 1542-3565. PMID 15017610.
  83. ↑ McFaul, C D (2006-02-01). "Anticipation in familial pancreatic cancer". Gut. 55 (2): 252–258. doi:10.1136/gut.2005.065045. ISSN 0017-5749. PMC 1856528. PMID 15972300.
  84. ↑ Grocock, C. J.; Rebours, V.; Delhaye, M. N.; Andren-Sandberg, A.; Weiss, F. U.; Mountford, R.; Harcus, M. J.; Niemczyck, E.; Vitone, L. J.; Dodd, S.; Jorgensen, M. T. (2009-12-01). "The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families". Gut. 59 (3): 357–363. doi:10.1136/gut.2009.186817. ISSN 0017-5749. PMID 19951905. Unknown parameter |s2cid= ignored (help)
  85. ↑ Neoptolemos, JP; Dunn, JA; Stocken, DD; Almond, J; Link, K; Beger, H; Bassi, C; Falconi, M; Pederzoli, P; Dervenis, C; Fernandez-Cruz, L (November 2001). "Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial". The Lancet. 358 (9293): 1576–1585. doi:10.1016/s0140-6736(01)06651-x. ISSN 0140-6736. PMID 11716884. Unknown parameter |s2cid= ignored (help)
  86. ↑ Carter, Ross; Stocken, Deborah D.; Ghaneh, Payla; Bramhall, Simon R.; Olah, Attila; Kelemen, Deszo; Bassi, Claudio; Friess, Helmut; Dervenis, Christo; Spry, Nigel; Büchler, Markus W. (2009-06-15). "Longitudinal quality of life data can provide insights on the impact of adjuvant treatment for pancreatic cancer-Subset analysis of the ESPAC-1 data". International Journal of Cancer. 124 (12): 2960–2965. doi:10.1002/ijc.24270. ISSN 0020-7136. PMID 19330830. Unknown parameter |s2cid= ignored (help)
  87. ↑ Neoptolemos, John P.; Stocken, Deborah D.; Bassi, Claudio; Ghaneh, Paula; Cunningham, David; Goldstein, David; Padbury, Robert; Moore, Malcolm J.; Gallinger, Steven; Mariette, Christophe; Wente, Moritz N. (2010-09-08). "Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection". JAMA. 304 (10): 1073–1081. doi:10.1001/jama.2010.1275. ISSN 0098-7484. PMID 20823433.
  88. ↑ Neoptolemos, John P.; Moore, Malcolm J.; Cox, Trevor F.; Valle, Juan W.; Palmer, Daniel H.; McDonald, Alexander C.; Carter, Ross; Tebbutt, Niall C.; Dervenis, Christos; Smith, David; Glimelius, Bengt (2012-07-11). "Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma". JAMA. 308 (2): 147–156. doi:10.1001/jama.2012.7352. ISSN 0098-7484. PMID 22782416.
  89. ↑ Greenhalf, William; Ghaneh, Paula; Neoptolemos, John P.; Palmer, Daniel H.; Cox, Trevor F.; Lamb, Richard F.; Garner, Elizabeth; Campbell, Fiona; Mackey, John R.; Costello, Eithne; Moore, Malcolm J. (2013-12-03). "Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial". JNCI: Journal of the National Cancer Institute. 106 (1): djt347. doi:10.1093/jnci/djt347. ISSN 1460-2105. PMID 24301456.
  90. ↑ Valle, Juan W.; Palmer, Daniel; Jackson, Richard; Cox, Trevor; Neoptolemos, John P.; Ghaneh, Paula; Rawcliffe, Charlotte L.; Bassi, Claudio; Stocken, Deborah D.; Cunningham, David; O'Reilly, Derek (2014-02-20). "Optimal Duration and Timing of Adjuvant Chemotherapy After Definitive Surgery for Ductal Adenocarcinoma of the Pancreas: Ongoing Lessons From the ESPAC-3 Study". Journal of Clinical Oncology. 32 (6): 504–512. doi:10.1200/jco.2013.50.7657. ISSN 0732-183X. PMID 24419109.
  91. ↑ Kleeff, Jörg; Costello, Eithne; Jackson, Richard; Halloran, Chris; Greenhalf, William; Ghaneh, Paula; Lamb, Richard F; Lerch, Markus M; Mayerle, Julia; Palmer, Daniel; Cox, Trevor (September 2016). "The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer". British Journal of Cancer. 115 (7): 887–894. doi:10.1038/bjc.2016.277. ISSN 0007-0920. PMC 5046218. PMID 27584663.
  92. ↑ Neoptolemos, John P; Palmer, Daniel H; Ghaneh, Paula; Psarelli, Eftychia E; Valle, Juan W; Halloran, Christopher M; Faluyi, Olusola; O'Reilly, Derek A; Cunningham, David; Wadsley, Jonathan; Darby, Suzanne (March 2017). "Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial". The Lancet. 389 (10073): 1011–1024. doi:10.1016/s0140-6736(16)32409-6. ISSN 0140-6736. PMID 28129987. Unknown parameter |s2cid= ignored (help)
  93. ↑ Ghaneh, Paula; Kleeff, Jorg; Halloran, Christopher M.; Raraty, Michael; Jackson, Richard; Melling, James; Jones, Owain; Palmer, Daniel H.; Cox, Trevor F.; Smith, Chloe J.; O’Reilly, Derek A. (March 2019). "The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma". Annals of Surgery. 269 (3): 520–529. doi:10.1097/sla.0000000000002557. ISSN 0003-4932. PMID 29068800. Unknown parameter |s2cid= ignored (help)
  94. ↑ Jones, Robert P.; Psarelli, Eftychia-Eirini; Jackson, Richard; Ghaneh, Paula; Halloran, Christopher M.; Palmer, Daniel H.; Campbell, Fiona; Valle, Juan W.; Faluyi, Olusola; O’Reilly, Derek A.; Cunningham, David (2019-11-01). "Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma". JAMA Surgery. 154 (11): 1038–1048. doi:10.1001/jamasurg.2019.3337. ISSN 2168-6254. PMC 6727687 Check |pmc= value (help). PMID 31483448.
  95. ↑ Bassi, Claudio; Dervenis, Christos; Butturini, Giovanni; Fingerhut, Abe; Yeo, Charles; Izbicki, Jakob; Neoptolemos, John; Sarr, Michael; Traverso, William; Buchler, Marcus (July 2007). "Postoperative pancreatic fistula: An international study group (ISGPF) definition". Surgery. 138 (1): 8–13. doi:10.1016/j.surg.2005.05.001. ISSN 0039-6060. PMID 16003309.
  96. ↑ Wente, Moritz N.; Bassi, Claudio; Dervenis, Christos; Fingerhut, Abe; Gouma, Dirk J.; Izbicki, Jakob R.; Neoptolemos, John P.; Padbury, Robert T.; Sarr, Michael G.; Traverso, L. William; Yeo, Charles J. (November 2007). "Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)". Surgery. 142 (5): 761–768. doi:10.1016/j.surg.2007.05.005. ISSN 0039-6060. PMID 17981197.
  97. ↑ Wente, Moritz N.; Veit, Johannes A.; Bassi, Claudio; Dervenis, Christos; Fingerhut, Abe; Gouma, Dirk J.; Izbicki, Jakob R.; Neoptolemos, John P.; Padbury, Robert T.; Sarr, Michael G.; Yeo, Charles J. (July 2007). "Postpancreatectomy hemorrhage (PPH)–An International Study Group of Pancreatic Surgery (ISGPS) definition". Surgery. 142 (1): 20–25. doi:10.1016/j.surg.2007.02.001. ISSN 0039-6060. PMID 17629996.
  98. ↑ Shukla, Parul J.; Barreto, Savio G.; Fingerhut, Abe; Bassi, Claudio; Büchler, Markus W.; Dervenis, Christos; Gouma, Dirk; Izbicki, Jakob R.; Neoptolemos, John; Padbury, Robert; Sarr, Michael G. (January 2001). "Toward improving uniformity and standardization in the reporting of pancreatic anastomoses: A new classification system by the International Study Group of Pancreatic Surgery (ISGPS)". Surgery. 147 (1): 144–153. doi:10.1016/j.surg.2009.09.003. ISSN 0039-6060. PMID 19879614.
  99. ↑ Hartwig, Werner; Vollmer, Charles M.; Fingerhut, Abe; Yeo, Charles J.; Neoptolemos, John P.; Adham, Mustapha; Andrén-Sandberg, Åke; Asbun, Horacio J.; Bassi, Claudio; Bockhorn, Max; Charnley, Richard (July 2014). "Extended pancreatectomy in pancreatic ductal adenocarcinoma: Definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS)". Surgery. 156 (1): 1–14. doi:10.1016/j.surg.2014.02.009. ISSN 0039-6060. PMID 24856668.
  100. ↑ Bockhorn, Maximilian; Uzunoglu, Faik G.; Adham, Mustapha; Imrie, Clem; Milicevic, Miroslav; Sandberg, Aken A.; Asbun, Horacio J.; Bassi, Claudio; Büchler, Markus; Charnley, Richard M.; Conlon, Kevin (June 2014). "Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS)". Surgery. 155 (6): 977–988. doi:10.1016/j.surg.2014.02.001. ISSN 0039-6060. PMID 24856119.
  101. ↑ Tol, Johanna A.M.G.; Gouma, Dirk J.; Bassi, Claudio; Dervenis, Christos; Montorsi, Marco; Adham, Mustapha; Andrén-Sandberg, Ake; Asbun, Horacio J.; Bockhorn, Maximilian; Büchler, Markus W.; Conlon, Kevin C. (Semptember 2014). "Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS)". Surgery. 156 (3): 591–600. doi:10.1016/j.surg.2014.06.016. ISSN 0039-6060. PMC 7120678 Check |pmc= value (help). PMID 25061003. Check date values in: |date= (help)
  102. ↑ Bassi, Claudio; Marchegiani, Giovanni; Dervenis, Christos; Sarr, Micheal; Abu Hilal, Mohammad; Adham, Mustapha; Allen, Peter; Andersson, Roland; Asbun, Horacio J.; Besselink, Marc G.; Conlon, Kevin (March 2017). "The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After". Surgery. 161 (3): 584–591. doi:10.1016/j.surg.2016.11.014. ISSN 0039-6060. PMID 28040257. Unknown parameter |s2cid= ignored (help)
  103. ↑ Shrikhande, Shailesh V.; Sivasanker, Masillamany; Vollmer, Charles M.; Friess, Helmut; Besselink, Marc G.; Fingerhut, Abe; Yeo, Charles J.; Fernandez-delCastillo, Carlos; Dervenis, Christos; Halloran, Christoper; Gouma, Dirk J. (May 2017). "Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS)". Surgery. 161 (5): 1221–1234. doi:10.1016/j.surg.2016.11.021. hdl:2262/79590. ISSN 0039-6060. PMID 28027816. Unknown parameter |s2cid= ignored (help)
  104. ↑ Siriwardena, Ajith K.; Windsor, John; Zyromski, Nicholas; Marchegiani, Giovanni; Radenkovic, Dejan; Morgan, Catherine; Passas, Ioannis; Olah, Attila; Conlon, Kevin C.; Smith, Martin; Busch, Olivier (July 2020). "Standards for reporting on surgery for chronic pancreatitis: a report from the International Study Group for Pancreatic Surgery (ISGPS)". Surgery. 168 (1): 101–105. doi:10.1016/j.surg.2020.02.007. ISSN 0039-6060. PMID 32183994 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  105. ↑ Miao, Yi; Lu, Zipeng; Yeo, Charles J.; Vollmer, Charles M.; Fernandez-del Castillo, Carlos; Ghaneh, Paula; Halloran, Christopher M.; Kleeff, Jörg; de Rooij, Thijs; Werner, Jens; Falconi, Massimo (July 2020). "Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS)". Surgery. 168 (1): 72–84. doi:10.1016/j.surg.2020.02.018. ISSN 0039-6060. PMID 32249092 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)

External links[edit]

Category:1951 births Category:Living people Category:British surgeons Category:Alumni of the University of Cambridge Category:Alumni of the University of London Category:Academics of the University of Liverpool Category:Heidelberg University faculty



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