Paul Sandford McGlothin
Paul Sandford McGlothin (born 1948 in Tennessee, currently in New York City) is most well-known as an author and consultant on calorie restriction (CR) and CR research.
Musical work[edit]
Paul McGlothin performed the clarinet with scholarships to Interlochen Arts Academy* and Oberlin Conservatory of Music as well as fellowships at the Tanglewood Music Center[1] and the National Orchestral Association* – followed by principal clarinet positions in symphony orchestras at Carnegie Hall and Lincoln Center for the Performing Arts. He organized events to honor the traditional music and dance of ethnicities in the United States and Puerto Rico – most notable being the Latin Dance Spectacular, the National Gospel Choir Competition, and the New York Hispanic Heritage Month Celebration.
Publications in Calorie Restriction[edit]
Paul McGlothin has attempted to bridge the gap between calorie restriction research and calorie restriction tools available to non-experts.[citation needed] He has attempted to integrate calorie restriction research with calorie restriction application in the following ways: a) The CR Way,[2] co-authored with his wife, Meredith Averill, and launched on Barbara Walters’ longevity special, "Living to 150: Can You Do It?" It presents an approach to CR that recognizes the special challenges and opportunities that human beings experience in applying CR, as compared to the lab animals that thrive on it; b) The CR Way to Happy Dieting,[3] an online resource that takes advantage of research in neurochemistry to support healthful weight-loss efforts by starting people on a diet that first deals biochemically with their food-related emotions; and c) the Web site, LivingTheCRWay.com, maintained to provide new research results as they develop and are evaluated. The CR Way "diet" is based on decades of research.[4]
Work in Longevity Research[edit]
Before the UCSF project, McGlothin and Averill helped assemble the CR cohort for human studies by Drs. Luigi Fontana and John Holloszy and their colleagues at the Washington University School of Medicine[5] This work has grown into the first longitudinal study of the effects of human calorie restriction with a focus on optimal nutrition[6][7][8][9][10]
In the late 1990s and early 2000s McGlothin collaborated with a variety of labs on several projects, including testing the beneficial effects of maintaining low circulating blood glucose, studying the effect on the lipid profile, produced by various dietary fats, and creating a pilot study on resveratrol that was reported at the 2004 CR Society Intl. Conference[11] in Charleston. McGlothin’s work in testing and reporting CR results and helping create calorie restriction research projects led to his being named Research VP* of the CR Society, where he works with scientists to plan studies. He also serves on the Society’s Board of Directors.*
In 2009, A. Janet Tomiyama, Ph.D., representing the laboratories of Elizabeth Blackburn (Biophysics and Biochemistry, UCSF) and Elissa Epel (Psychiatry, UCSF), invited McGlothin and Averill to collaborate in developing a human CR research project: Calorie Restriction with Optimal Nutrition and Aging (CRONA), including researchers in several related fields: Anne Brunet (Genetics, Stanford), Pankaj Kapahi (Buck Institute for Age Research), Cynthia Kenyon, (Biophysics and Biochemistry, UCSF), Jue Lin (Biochemistry & Biophysics, UCSF). Eric Verdin (Gladstone Institute of Virology and Immunology* and UCSF). By early 2011 much of the data gathering had been accomplished.
Notes and references[edit]
- ↑ See especially the Students and Faculty section in Tanglewood Music Center
- ↑ The CR Way, by Paul McGlothin and Meredith Averill. (2008) New York: HarperCollins.
- ↑ The CR Way to Happy Dieting, by Paul McGlothin and Meredith Averill. (2010) LivingTheCRWay.com *
- ↑ Fontana, L; Partridge, L; Longo, VD (2010). "Extending Healthy Life Span — From Yeast to Humans". Science. 328 (5976): 321–326. doi:10.1126/science.1172539. PMC 3607354. PMID 20395504.
- ↑ Fontana, L; Meyer, TE; Klein, S; Holloszy, JO (2004). "Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans". Proc Natl Acad Sci USA. 101 (17): 6659–63. doi:10.1073/pnas.0308291101. PMC 404101. PMID 15096581.
- ↑ Meyer, TE; Kovacs, SJ; Ehsani, AA; Klein, S; Holloszy, JO; Fontana, L (2006). "Long-term caloric restriction ameliorates the decline in diastolic function in humans". J Am Coll Cardiol. 47 (2): 398–402. doi:10.1016/j.jacc.2005.08.069. PMID 16412867.
- ↑ Fontana, L; Klein, S; Holloszy, JO; Premachandra, BN (2006). "Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones". J Clin Endocrinol Metab. 91 (8): 3232–5. doi:10.1210/jc.2006-0328. PMID 16720655.
- ↑ Fontana, L; Weiss, EP; Villareal, DT; Klein, S; Holloszy, JO (2008). "Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans". Aging Cell. 7 (5): 681–7. doi:10.1111/j.1474-9726.2008.00417.x. PMC 2673798. PMID 18843793.
- ↑ Fontana, L; Klein, S; Holloszy, JO (2010). "Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production". Age. 32 (1): 97–108. doi:10.1007/s11357-009-9118-z. PMC 2829643. PMID 19904628.
- ↑ Cangemi, R; Friedmann, AJ; Holloszy, JO; Fontana, L (2010). "Long-term effects of calorie restriction on serum sex-hormone concentrations in men". Aging Cell. 9 (2): 236–42. doi:10.1111/j.1474-9726.2010.00553.x. PMC 3569090. PMID 20096034.
- ↑ McGlothin P (2004). "Resveratrol - CR Mimetic?" CR Society Intl. Conference DVD: CRIII
External links[edit]
- Interlochen Arts Academy, Photos from 1960s Alums — Young Paul McGlothin in Performance
- National Orchestral Association Web site
- UCSF Collaboration The CR Way to Happy Dieting presentation by McGlothin at UCSF
- Research VP and Director of the CR Society Intl.
- Gladstone Institute of Virology and Immunology Web page
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