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Pravat Kumar Mandal

From EverybodyWiki Bios & Wiki





Pravat Kumar Mandal
BornWest Bengal, India
🏳️ NationalityIndian
💼 Occupation
Known forNeuroscience research

Pravat Kumar Mandal is an Indian neuroscientist. Presently, he is the Professor, Scientist, and Director-in-Charge of National Brain Research Centre and Honorary Professor at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. His major area of research involves studying neuropsychiatric and neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, using multimodal brain imaging techniques.[1][2]

Academic Profile

In 1995, Mandal received his Ph.D. from IIT Madras in “Exchange interactions in some bimetallic systems: experimental and theoretical approach.” From March 2004 to Jun 2008, he worked as an assistant professor in Psychiatry in The University of Pittsburgh Medical school, and from Feb 2011 to May 2016, as an Associate Prof. (Adj) (Radiology) at Johns Hopkins School of Medicine, Maryland, USA. He is currently an Honorary professor at the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.[3][4]

Mandal joined NBRC in 2008 as a scientist and faculty member. Today, he serves as scientist VII and the Director-in-Charge of the institute. He has established an independent lab at NBRC called the NeuroImaging and NeuroSpectroscopy (NINS) laboratory wherein his research team focuses on developing novel neuroimaging protocols, tools, and databases using multimodal neuroimaging approach for studying neurodegenerative and neuropsychiatric disorders, including Alzheimer's disease.[5]

Research Profile

Mandal's research focuses on studying early neurochemical–functional biomarkers for neurodegenerative disorders, including Alzheimer's and Parkinson's disease. His work uses non-invasive neuroimaging approach to investigate brain alterations in healthy aging and neurodegenerative disorders and develop neuroimaging tools and databases for processing of neuroimaging data.

Clinical Research and Discoveries

Mandal's team discovered early diagnostic markers of AD, wherein they showed that cognitive decline in AD is directly correlated to glutathione (GSH) depletion in the hippocampus and frontal and cingulate cortical regions.[6][7][8][9][10] His work explains the involvement of GSH depletion in the pathophysiology of MCI, demonstrating that increased oxidative stress induces GSH depletion and pH alteration.[11] Using 31P MRS, Mandal's team discovered that left hippocampal pH in AD-affected brains becomes alkaline.[12][13] His team also discovered that GSH molecule is expressed in closed and extended forms in the brain and identified that the closed GSH is often depleted in the brains affected with AD.[14][15][16][17][18][19]

Translational Research and Innovation

SWADESH

In October 2021, Mandal's team launched project SWADESH, which is the first large-scale multimodal neuroimaging database designed specifically for Indian population with big-data architecture and analytics for various disease categories under one platform. The database focuses on certified neuroimaging, neurochemical, neuropsychological data and analytics that are made accessible to researchers for managing brain disorders. Researchers from around the world can use this data/information for better defining a disease based on the analysis of imaging-based biomarkers.[20][21]

SWADESH was inaugurated by Dr. Jitendra Singh, Union Minister of State (Independent Charge) for the Ministry of Science and Technology on 19th November 2021. Upon the launch, Dr Rajesh Gokhale, Secretary, Department said, “Databases like SWADESH should be useful in conducting multimodal brain studies to understand Alzheimer’s disease and several neurological disorders.”[22]

ANSH

In October 2020, Mandal developed a brain neurochemical–neuroimaging database to help recognize cellular–molecular processes leading to various neurodegenerative–neuropsychiatric diseases. ANSH includes neurochemical levels, such as GSH and gamma aminobutyric acid (GABA), and MRI-based data for AD, mild cognitive impairment, and healthy subjects.[23]

KALPANA

In March 2020, Mandal developed KALPANA, an integrative MATLAB-based package for visualization, preprocessing, and quantitation of MRS data obtained using several acquisition methods. This free-for-public-access package aids in the diagnosis of brain disorders prior to their occurrence using oxidative stress and pH level analysis.[24]

BRAHMA

In July 2020, Mandal and his research team developed a novel brain template called “BRAHMA” using the brain scans of healthy Indians. BRAHMA provides details about the brain structures and regions and helps analyze brain images of various population groups (specific to Indian population). It also provides several image contrasts, segmentation atlases, and tissue maps for multimodal data and image analysis.[25][26][27]

BHARAT

In February 2019, the research team developed a Hadoop-based big data framework that integrates neuroimaging test outcomes to identify early diagnostic biomarkers of AD. The framework consists mainly of machine learning and statistical modeling. The work was published in Frontiers in Neurology[28] and covered by several platforms.[29]

Awards & honours

Mandal has been awarded with “Global Artificial Intelligence Award” (Category: Lifetime Achievement Award) by All India Council for Robotics & Automation[30] and TATA Innovation Fellow, Department of Biotechnology, Govt of India.

Throughout his quest, Mandal has delivered several talks and lectures at national and international level, including keynote addresses at IIT Indore (Topic: Digital Diagnosis using Neuroimaging Modalities: Tools and Applications; Dec 2017) as well as Anesthesia and Peri-Operative Care in the Seventh Age Anesthesia Association Annual Scientific Meeting, Stratford-upon-Avon, England, UK (Topic: Anesthetics simulating molecular mechanism of Alzheimer's disease; May 2013). He has delivered oral presentations at International meeting on Cognition, Italian Ministry for Education, University and Research, Barcelona, Spain (Topic: Anaesthetics and Impact on Cognition; Jun 2010); International Conference on Physics Biology Interface, Saha Institute of Nuclear Physics, India (Topic: In vivo MRS spectroscopy on Alzheimer patients; Dec 2009); and International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, PA, USA (Topic: Oligomeric amyloid beta by NMR spectroscopy; May 2005).

Editorial Responsibilities

Mandal is the Regional Editor and Associate Editor for the Journal of Alzheimer's Disease[31]. In 2019, he was a Research Topic Editor for Frontiers in Neurology[32]. In his profession, he was also elected to be the Guest Editor for Journal of Alzheimer's Disease in 2010[33] and 2012[34] as well as for American Journal of Neuroradiology in 2014[35] Mandal is a member of several professional societies, including International Society for Magnetic Resonance in Medicine (Apr 2011–Jun 2013)[36], Society of Biological Psychiatry (May 2005–till date), and Society for Neuroscience (Jan 2003–till date).

External links

References

  1. ↑ "Robust AI system is good for early diagnosis of Alzheimer's disease". AICRA. Retrieved 11 January 2022.
  2. ↑ "Mandal". ORCID connecting research and researchers. ORCID. Retrieved 28 October 2021.
  3. ↑ Mandal, Pravat Kumar. "National Brain Research Centre Scholar Profiles". National Brain Research Centre. Retrieved 11 January 2022.
  4. ↑ "Pravat Kumar Mandal". ResearchGate. Retrieved 28 October 2021.
  5. ↑ "Pravat K Mandal". Loop The Open Science Research Network. Frontiers. Retrieved 11 January 2022.
  6. ↑ "Anti-oxidant level in specific brain region indicates early signs of Alzheimer's: Study". DownToEarth. Retrieved 11 January 2022.
  7. ↑ Mandal, Pravat Kumar (1 January 2016). "Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer's Disease". Biological Psychiatry. 78 (10): 702–710. doi:10.1016/j.biopsych.2015.04.005. PMID 26003861. Unknown parameter |s2cid= ignored (help)
  8. ↑ Saharan, Sumiti (23 April 2014). "The Emerging Role of Glutathione in Alzheimer's Disease". Journal of Alzheimer's Disease. 40 (3): 519–529. doi:10.3233/JAD-132483. PMID 24496077. Retrieved 11 January 2022.
  9. ↑ Mandal, Pravat Kumar (6 January 2012). "Brain oxidative stress: Detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy". Biochemical and Biophysical Research Communications. 417 (1): 43–48. doi:10.1016/j.bbrc.2011.11.047. PMID 22120629. Retrieved 11 January 2022.
  10. ↑ "Indian Science in India Media" (PDF). Vigyan Prasar. Dept of Science and Technology, Govt. of India. Retrieved 11 January 2022.
  11. ↑ Shukla, Deepika (September 2021). "Hippocampal Glutathione Depletion and pH Increment in Alzheimer's Disease: An in vivo MR Spectroscopic Study". Journal of Alzheimer's Disease. 84 (3): 1139–1152. doi:10.3233/JAD-215032. PMID 34633325 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  12. ↑ Mandal, Pravat Kumar (13 January 2021). "Hippocampal pH rise towards alkalinity: A perfect storm for Alzheimer's disease". npj Science of Learning. Springer Nature. Retrieved 11 January 2022.
  13. ↑ Mandal, Pravat Kumar (18 September 2012). "Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease". Journal of Alzheimer's Disease. 31 (3): S75–86. doi:10.3233/JAD-2012-120166. PMID 22426021.
  14. ↑ Shukla, Deepika; Mandal, Pravat K.; Ersland, Lars; Grüner, Eli Renate; Tripathi, Manjari; Raghunathan, Partha; Sharma, Ankita; Chaithya, G.R.; Punjabi, Khushboo; Splaine, Christopher (August 2018). "A Multi-Center Study on Human Brain Glutathione Conformation using Magnetic Resonance Spectroscopy". Journal of Alzheimer's Disease. 66 (2): 517–532. doi:10.3233/JAD-180648. PMC 6218146. PMID 30198874. Retrieved 11 January 2022.
  15. ↑ Mandal, Pravat Kumar (2017). "Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy". Journal of Alzheimer's Disease. 59 (2): 537–541. doi:10.3233/JAD-170350. PMC 5523836. PMID 28527221. Retrieved 11 January 2022.
  16. ↑ Deepika, Shukla (September 2019). "Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS". Human Brain Mapping. 41 (1): 195–217. doi:10.1002/hbm.24799. PMC 7268069 Check |pmc= value (help). PMID 31584232. Retrieved 11 January 2022.
  17. ↑ Mandal, Pravat Kumar (22 April 2020). "Alzheimer's and The Glutathione Story". npj Science of Learning. Springer Nature. Retrieved 11 January 2022.
  18. ↑ "Early detection of cognitive disorders necessary, say doctors". The Times of India. Retrieved 11 January 2022.
  19. ↑ "Anti-oxidant level in specific brain region early sign of Alzheimer's: Study". Indus Dictum. 22 October 2019. Retrieved 11 January 2022.
  20. ↑ Mandal, Pravat Kumar (October 2021). "SWADESH: A Comprehensive Platform for Multimodal Data and Analytics for Advanced Research in Alzheimer's and other Brain Disorders". Journal of Alzheimer's Disease. 85 (1): 1–5. doi:10.3233/JAD-215354. PMID 34744083 Check |pmid= value (help). Unknown parameter |s2cid= ignored (help)
  21. ↑ "Swadesh to host repository of big data on brain disorders". Bharat Times. 26 October 2021. Retrieved 11 January 2022.
  22. ↑ "SWADESH, World's First Multimodal Brain Imaging Data and Analytics, Developed at DBT-National Brain Research Centre, Haryana". Ministry of Science & Technology, Govt. of India. PIB Delhi. 26 November 2021. Retrieved 11 January 2022.
  23. ↑ Mandal, Pravat Kumar (20 October 2020). "ANSH: Multimodal Neuroimaging Database Including MR Spectroscopic Data From Each Continent to Advance Alzheimer's Disease Research". Frontiers in Neuroinformatics. 14: 43. doi:10.3389/fninf.2020.571039. PMC 7641007 Check |pmc= value (help). PMID 33214792 Check |pmid= value (help).
  24. ↑ Mandal, Pravat Kumar (19 May 2020). "KALPANA: Advanced Spectroscopic Signal Processing Platform for Improved Accuracy to Aid in Early Diagnosis of Brain Disorders in Clinical Setting". Journal of Alzheimer's Disease. 75 (2): 397–402. doi:10.3233/JAD-191351. PMID 32200359 Check |pmid= value (help). Retrieved 13 January 2022. Unknown parameter |s2cid= ignored (help)
  25. ↑ Pai, Praful (July 2020). "BRAHMA: Population specific T1, T2, and FLAIR weighted brain templates and their impact in structural and functional imaging studies". Magnetic Resonance Imaging. 70: 5–21. doi:10.1016/j.mri.2019.12.009. PMID 31917995. Retrieved 11 January 2022. Unknown parameter |s2cid= ignored (help)
  26. ↑ "Dr Pravat K Mandal- the man behind India's ambitious 'BRAHMA' project". Pixstory. Pixstory. Retrieved 11 January 2022.
  27. ↑ Koshy, Jacob (30 March 2018). "In Haryana, the making of an Indian brain template". The Hindu. Retrieved 11 January 2022.
  28. ↑ Sharma, Ankita (February 2019). "BHARAT: An Integrated Big Data Analytic Model for Early Diagnostic Biomarker of Alzheimer's Disease" (PDF). Frontiers in Neurology. 10 (9): 9. doi:10.3389/fneur.2019.00009. PMC 6375828. PMID 30800093. Retrieved 11 January 2022.
  29. ↑ Sharma, Dinesh C (28 January 2019). "Big Data may help get new clues to Alzheimer's". The Hindu. Retrieved 11 January 2022.
  30. ↑ "Global AI Summit 2019 and Launch of FutureTech Magazine". APN News. APN News. 24 January 2019. Retrieved 11 January 2022.
  31. ↑ Mandal, Pravat. "Pravat Mandal, PhD". Journal of Alzheimer's Disease. Journal of Alzheimer's Disease. Retrieved 12 January 2022.
  32. ↑ Mandal, Pravat Kumar. "Predictive Imagable Biomarkers for Neurodegenerative and Neurodevelopmental Diseases". Frontiers in Neurology. Frontiers. Retrieved 12 January 2022.
  33. ↑ "Anesthetics and Alzheimer's Disease: Background and Research". Journal of Alzheimer's Disease. IOS Press. 22 (s3). Retrieved 12 January 2022.
  34. ↑ Mandal, Pravat. "Select this result for bulk action CitePredictive Biomarkers for Alzheimer's Disease Using State-of-the-Art Brain Imaging Techniques". Journal of Alzheimer's Disease. IOS Press. 31 (s3). Retrieved 12 January 2022.
  35. ↑ "Brain Metabolic Mapping with MRS: A Potent Noninvasive Tool for Clinical Diagnosis of Brain Disorders". American Journal of Neuroradiology. 35 (6 suppl). June 2014. Retrieved 12 January 2022.
  36. ↑ "International Society for Magnetic Resonance in Medicine". ismrm. International Society for Magnetic Resonance in Medicine. Retrieved 12 January 2022.


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