DC Biosciences Ltd
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| Limited Company | |
| ISIN | 🆔 |
| Industry | Biotechnology |
| Founded 📆 | 2006 |
| Founder 👔 | |
| Headquarters 🏙️ | Dundee, Scotland, UK |
Area served 🗺️ | |
| Products 📟 | Biochemical reagents, specialised research products such as SILAC media |
| Services | Proteomics, DNA cloning, gene synthesis, antibody development, protein expression and purification |
| Members | |
Number of employees | |
| 🌐 Website | http://https://www.dcbiosciences.com/ |
| 📇 Address | |
| 📞 telephone | |
DC Biosciences Ltd. (formerly known as Dundee Cell Products) is a biotechnology company specialising in proteomics services to pharmaceutical sector companies and academics, and headquartered in Dundee, Scotland, United Kingdom. The proteomics services offered by the company include counselling for experiment design, sample processing, mass-spectrometry analysis, as well as output data and visual data analysis. Typical workflows include analysis of label-free, SILAC-, TMT and iTRAQ-labelled samples using Data Dependent Acquisition methods, as well as since end 2017 Data Independent Acquisition (DIA) Proteomics. Common projects range in complexity from quality testing of purified protein fractions, pull downs (immune-precipitations, proximity proteomics), biomarker identification analysis, to extensive full proteome analysis including offline fractionation and port-translational modification enrichment. The company’s approach to Proteomics services is bespoke individualised, with each aspect of each new project discussed with the customer at length before start. In addition to proteomics services, DC Biosciences also offers peptide and gene synthesis and sells bioreagents for biochemistry, molecular biology and cell biology research, notably antibodies and SILAC cell culture media. The company’s business activities also include research and development of new innovative products and services, commercialization of products in-licensed from academic institutions, distribution of life sciences research products from commercial partners and supply of contract research services to customers from both academia and pharmaceutical/biotechnology companies.
History[edit]
The original Dundee Cell Products Ltd was founded in 2006 as a spinout of the internationally renowned School of Life Sciences[1] of the University of Dundee Prof. Angus Lamond (Lamond Lab). Since spinout the company has maintained close interactions with researchers at the institution and a strong relationship with the University. In 2007 the company secured equity investment funding from a syndicate of angel investors to finance and expand its activities with follow up investment secured in 2009 from angel investors and the Scottish Co-investment Fund (SCF).[2] The investment was secured to support the business’s growth plans. Over the last four years DCB has enjoyed significant growth in its products portfolio and turnover. In 2017, DCB was re-branded to DC Biosciences, and refocused its business on the fast emerging market of proteomics services. End of 2017, DC Biosciences started offering cutting edge Data Independent Analysis (DIA) Proteomics services.
Research and innovation[edit]
In the past three years, the company has expanded its capacities to offer a wide variety of proteomics services, and developed and commercialized several new products e.g. SILAC ready to use media and has been involved in proteomics research collaborations with scientists in both academic institutions and pharmaceutical companies. Some of these projects have been designed to investigate the effects of virus infections on cellular proteomes in order to elucidate the mechanisms and cellular pathways involved in virus–host factor interactions.[3] DCB has also collaborated in a phosphoproteomics project[4] designed to study the molecular mechanisms in the pathogenesis of transmissible spongiform encephalopathies (TSEs) or prion disease. Transmissible spongiform encephalopathies are fatal diseases associated with the conversion of the cellular prion protein to an abnormal prion protein leading to damage of brain and neural tissue. Examples of prion diseases include bovine spongiform encephalopathy (BSE, also known as "mad cow disease") in cattle and Creutzfeldt–Jakob disease (CJD) in humans. There is currently no treatment for prion diseases, which are usually fatal to the host.
As of 2016 DCB is part of the ADAPTED Project. The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project was created to investigate a previously neglected area of Alzheimer's Disease (AD) research. The the ADAPTED partners are: Fundació ACE, AbbVie, Biogen, CAEBI Bioinformatica SL, Spanish National Research Council, DC Biosciences Ltd., Erasmus Medical Centre, Janssen Pharmaceutica NV, Kite Innovation Europe, Leiden University, Mimetas BV, Universitaetsklinikum Bonn and University Hospital of Cologne.
Current R&D projects within the company have been focused on developing applications for SILAC quantitative proteomics in predictive toxicology. These projects are designed to provide data that will be used in developing predictive models for drug toxicity early on during the drug discovery and development process.
Portfolio[edit]
DCB initially developed antibodies, mammalian cell fractions for precursor mRNA splicing research and tissue culture media specifically formulated for SILAC quantitative proteomics. The first products commercialized by the company came from the research interests of the founding scientists who saw an opportunity in the market for developing and commercializing high quality research products and services in the research area to other colleagues. The company has subsequently expanded its products and services portfolio into many other areas of life sciences research to better cover the needs of its customers.
Product lines[edit]
Dundee Cell Products commercializes a broad range of life sciences research products (many of which have been developed in-house) including cell culture media for quantitative proteomics, mammalian cell fractions e.g. nuclei, nucleoli, mitochondria and cell fractions for quantitative proteomics, antibodies, recombinant proteins, fluorescent cell markers and primary mammalian cells. The company’s SILAC ready to use media have been specially formulated to facilitate the use of SILAC technology by non-specialists in proteomics and scientists who are interested in the application of unbiased high throughput quantitative proteomics approaches in their R&D activities.
Research services[edit]
As well as offering research products, the company’s portfolio has grown to include research services designed to accelerate the research activities of scientists in both the academic and biotech/pharmaceutical industry sectors. Some of the research services that DCP offers include gene synthesis, DNA cloning, recombinant protein expression and purification, stable cell line development, custom monoclonal and polyclonal antibody development and various proteomics services[5] i.e. both quantitative (e.g. SILAC, Tandem Mass Tags (TMT), iTRAQ, label-free) qualitative and DIA.
Corporate information[edit]
- Mr John Ivinson - Chief Executive Officer
- Dr Francesco Rao - Chief Scientific Officer
- Professor Angus Lamond - Scientific Advisor
References[edit]
- ↑ "School of Life Sciences". Lifesci.dundee.ac.uk. Retrieved 2012-12-27.
- ↑ https://web.archive.org/web/20110106205706/https://www.scottish-enterprise.com/fund-your-business/scottish-investment-bank/scif.aspx. Archived from the original on January 6, 2011. Retrieved May 16, 2011. Missing or empty
|title=(help) - ↑ Emmott E., Rodgers M.A., Macdonald A., McCrory S., Ajuh P., Hiscox J.A. (2010) Mol. Cell. Proteomics, 9, 1920-1936
- ↑ Wagner W., Ajuh P., Löwer J., Wessler S. (2010) Cell. Commun. Signal. 8, 28
- ↑ "Dundee Cell Proteomics". Dundee Cell Proteomics. Retrieved 2012-12-27.
External links[edit]
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