Labcyte Inc.
| Private | |
| ISIN | 🆔 |
| Industry | Biotechnology |
| Founded 📆 | 2000 |
| Founder 👔 | Richard Ellson |
| Headquarters 🏙️ | , , |
Area served 🗺️ | |
Key people | Mark Fischer-Colbrie (CEO) |
| Products 📟 | Echo, Access, MicroClime |
| Members | |
Number of employees | |
| 🌐 Website | www |
| 📇 Address | |
| 📞 telephone | |
Coordinates: 37°25′03″N 121°56′58″W / 37.417581°N 121.949358°W
Labcyte Inc. is a biotechnology company based in San Jose, California, that manufactures acoustic liquid handling systems for life science research. The company provides a line of liquid handling, automation, software, and consumable products that serve the scientific research industry for drug discovery, genomics, cancer research, and sample management.[1]
The company's acoustic droplet ejection technology allows liquids to be transferred using sound energy. This non-contact method eliminates the use of pipette tips or nozzles and provides a coefficient of variation (CV) that is lower than other techniques and is independent of volume.[2],[3],[4]
History[edit]
Labcyte was founded in 2000 by Richard Ellson, who developed the core technology to move fluids with sound waves.[5] By 2004 the company had been granted 13 patents for its Echo liquid handlers and had begun beta testing its first instrument.[6],[7] In 2008, it merged with Deerac Fluidics, a liquid handling company based in Dublin, Ireland.[8]
Company investors include Abingworth_(company) Management, Alloy Ventures, Delphi Ventures, Cross Atlantic Partners, Hambrecht & Quist Capital Management, the Bay Area Equity Fund, the Sprout Group, and GE Ventures.[9][10]
In 2013, Labcyte partnered with the Institute for Molecular Medicine Finland at the University of Helsinki for a personalized medicine study.[11]
Technology[edit]
Acoustic droplet ejection technology focuses ultrasonic acoustic energy at the meniscus of a fluid sample to eject small droplets of liquid from wells and position them onto a surface suspended above the ejection point.[12],[13]
Dynamic fluid analysis enables the system to adapt to different types of fluids. This patented algorithm adjusts acoustic energy requirements in real time without operator intervention. It is able to determine fluid composition, fluid height, and the power needed to eject the correct volume of fluid into the destination well.[14] This analysis happens rapidly, allowing for transfers of nanoliter (nL) droplets into an inverted destination plate. Large volume transfers are achieved by transferring several hundred droplets per second.
Applications[edit]
Drug discovery: Labcyte products are used for sample management, genotyping, and other high-volume genomics pipelines in the drug discovery and development process.[15],[16],[17],[18] Scientists have also used acoustic technology with mass spectrometry for screening purposes.[19],[20],[21],[22],[23]
Synthetic biology: Acoustic droplet ejection technology is used to reduce experimental time and reagent volumes for gene synthesis pipelines. It is also used for sequencing-based quality control protocols to ensure accurate synthesis.[24],[25],[26],[27],[28],[29]
Cancer research: Users have incorporated Labcyte instruments for high-throughput personalized medicine, testing oncology drugs against cells collected directly from patients with cancer to determine which medications work best against each patient's specific form of cancer.[30],[31],[32]
Genomics research: Scientists target individual cells for genomics research, such as for analysis of heterogeneous microbial communities.[33],[34],[35],[36]
Products[edit]
Labcyte produces a series of Echo liquid handlers using acoustic droplet ejection technology to miniaturize reaction volumes and reduce the amount of reagents needed.[37],[38],[39] Instruments range in capacity and transfer volume.
The company also sells the Access Workstation, which makes it possible to integrate Echo liquid handlers with genomic and other high-throughput scientific workflows.
In 2018, Labcyte began offering the Access Dual-Robot System and the Echo 655T liquid handler, part of an acoustic sample management system for high-throughput new drug screening developed in collaboration with AstraZeneca, Brooks Life Sciences, and Titian Software.[40],[41],[42]
References[edit]
- ↑ "Labcyte Information on Bloomberg". bloomberg.com. Retrieved 2018-02-20.
- ↑ Kanigowska, Paulina; Shen, Yue; Zheng, Yijing; Rosser, Susan; Cai, Yizhi (2016). "Smart DNA Fabrication Using Sound Waves: Applying Acoustic Dispensing Technologies to Synthetic Biology". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 49–56. doi:10.1177/2211068215593754. PMC 4814025. PMID 26163567. Retrieved 2015-07-10.
- ↑ "Labcyte: Enhancing BioTech Experiments with Acoustics". biotech.cioreview.com.
- ↑ "Labcyte Demonstrates 'Sound' Transfer". bio-itworld.com. Retrieved 2006-01-01.
- ↑ "How Richard Ellson and Mark Fischer-Colbrie used Labcyte to transform life science research". sbnonline.com. Retrieved 2013-07-01.
- ↑ "Labcyte Continues to Garner IP for Assay Applications on Acoustic Compound Reformatter". genomeweb.com. Retrieved 2004-11-02.
- ↑ "Technologies That Enable Accurate and Precise Nano to Milliliter-Scale Liquid Dispensing of Aqueous Reagents Using Acoustic Droplet Ejection". journals.sagepub.com. doi:10.1177/2211068215602191%20. Retrieved 2015-09-04.
- ↑ "Labcyte, Deerac Fluidics merge for improved liquid handling". in-pharmatechnologist.com. Retrieved 2008-01-29.
- ↑ "Oxford Finance and Silicon Valley Bank Close $17 Million Debt Facility with Labcyte". prnewswire.com. Retrieved 2015-05-15.
- ↑ "Labcyte financing". genomeweb.com. Retrieved 2005-07-25.
- ↑ "Labcyte, University of Helsinki Extend Personalized Medicine Collaboration". genomeweb.com. Retrieved 2017-11-08.
- ↑ Hadimioglu, Babur; Stearns, Richard; Ellson, Richard (2016). "Moving Liquids with Sound: The Physics of Acoustic Droplet Ejection for Robust Laboratory Automation in Life Sciences". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 4–18. doi:10.1177/2211068215615096. PMID 26538573. Retrieved 2015-11-04.
- ↑ "Labcyte awarded U.S. patent for transferring liquids within sealed containers". news-medical.net. Retrieved 2008-12-10.
- ↑ "Technologies That Enable Accurate and Precise Nano to Milliliter-Scale Liquid Dispensing of Aqueous Reagents Using Acoustic Droplet Ejection". journals.sagepub.com. doi:10.1177/2211068215602191%20. Retrieved 2015-09-04.
- ↑ Cain-Hom, Carol; Pabalate, Ryan; Pham, Anna; Patel, Hetal N; Wiler, Rhonda; Cox, J. Colin (2016). "Mammalian Genotyping Using Acoustic Droplet Ejection for Enhanced Data Reproducibility, Superior Throughput, and Minimized Cross-Contamination". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 37–48. doi:10.1177/2211068215601637. PMID 26311060. Retrieved 2015-08-26.
- ↑ Agrawal, Sony; Cifelli, Steven; Johnstone, Richard; Pechter, David; Barbey, Deborah A; Lin, Karen; Allison, Tim; Agrawal, Shree; Rivera-Gines, Aida; Milligan, James A; Schneeweis, Jonathan; Houle, Kevin; Struck, Alice J; Visconti, Richard; Sills, Matthew; Wildey, Mary Jo (2016). "Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 57–63. doi:10.1177/2211068215609315. PMID 26460107. Retrieved 2015-10-12.
- ↑ "Technology innovation will help prepare drug discovery for smart screening era". ddw-online.com. Retrieved 2018-02-20.
- ↑ "Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis". onlinelibrary.wiley.com. doi:10.1002/cmdc.201200428/abstract (inactive 2018-07-09). Retrieved 2013-01-10.
- ↑ "Acoustic mass spectrometer platform". astrazeneca.com. Retrieved 2018-02-20.
- ↑ "GSK joins AstraZeneca and Labcyte to develop acoustic mass spectrometry". pharmaceutical-technology.com. Retrieved 2017-09-21.
- ↑ Sinclair, I; Stearns, R; Pringle, S; Wingfield, J; Datwani, S; Hall, E; Ghislain, L; Majlof, L; Bachman, M (2016). "Novel Acoustic Loading of a Mass Spectrometer: Toward Next-Generation High-Throughput MS Screening". Journal of Laboratory Automation. 21 (1): 19–26. doi:10.1177/2211068215619124. PMID 26721821.
- ↑ Zhang, Hui (2017). "Acoustic dispensing-mass spectrometry: the next high throughput bioanalytical platform for early drug discovery". Bioanalysis. future-science.com. 9 (21): 1619–1621. doi:10.4155/bio-2017-4980. PMID 29095041. Retrieved 2017-05-02.
- ↑ "Labcyte on Scrip". scrip.pharmaintelligence.informa.com. Retrieved 2017-05-02.
- ↑ Kanigowska, Paulina; Shen, Yue; Zheng, Yijing; Rosser, Susan; Cai, Yizhi (2016). "Smart DNA Fabrication Using Sound Waves: Applying Acoustic Dispensing Technologies to Synthetic Biology". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 49–56. doi:10.1177/2211068215593754. PMC 4814025. PMID 26163567. Retrieved 2015-07-10.
- ↑ "Labcyte's acoustic droplet ejection technology is miniaturizing high-throughput assembly". synbiobeta.com. Retrieved 2018-01-24.
- ↑ "With synthetic biology, drug discovery is going virtual". ddw-online.com. Retrieved 2016-07-01.
- ↑ "Echo acoustic liquid handling and synthetic biology". the-scientist.com. Retrieved 2017-10-16.
- ↑ "Echo acoustic liquid handling and synthetic biology". science.sciencemag.com. Retrieved 2017-03-10.
- ↑ "Making the synthetic yeast chromosomes cover and introductory spread image". science.sciencemag.com. Retrieved 2017-03-10.
- ↑ Shapland, Elaine B; Holmes, Victor; Reeves, Christopher D; Sorokin, Elena; Durot, Maxime; Platt, Darren; Allen, Christopher; Dean, Jed; Serber, Zach; Newman, Jack; Chandran, Sunil (2015). "Low-Cost, High-Throughput Sequencing of DNA Assemblies Using a Highly Multiplexed Nextera Process". ACS Synthetic Biology. pubs.acs.org. 4 (7): 860. doi:10.1021/sb500362n. PMID 25913499. Retrieved 2015-04-25.
- ↑ Eriksson, A; Österroos, A; Hassan, S; Gullbo, J; Rickardson, L; Jarvius, M; Nygren, P; Fryknäs, M; Höglund, M; Larsson, R (2015). "Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia". Blood Cancer Journal. 5 (4): e307. doi:10.1038/bcj.2015.31. PMC 4450329. PMID 25885427.
- ↑ "Notable Labs to Use Labcyte Technology in Cell-Based Individualized Cancer Therapy Selection". genomeweb.com. Retrieved 2016-12-07.
- ↑ "A personalised medicine drug sensitivity and resistance testing platform and utilisation of acoustic droplet ejection at the Institute for Molecular Medicine Finland". sciencedirect.com. Retrieved 2014-09-01.
- ↑ Kulesskiy, Evgeny; Saarela, Jani; Turunen, Laura; Wennerberg, Krister (2016). "Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 27–36. doi:10.1177/2211068215618869. PMID 26721820. Retrieved 2015-12-02.
- ↑ Kaufmann, Markus; Schuffenhauer, Ansgar; Fruh, Isabelle; Klein, Jessica; Thiemeyer, Anke; Rigo, Pierre; Gomez-Mancilla, Baltazar; Heidinger-Millot, Valerie; Bouwmeester, Tewis; Schopfer, Ulrich; Mueller, Matthias; Fodor, Barna D; Cobos-Correa, Amanda (2015). "High-Throughput Screening Using iPSC-Derived Neuronal Progenitors to Identify Compounds Counteracting Epigenetic Gene Silencing in Fragile X Syndrome". Journal of Biomolecular Screening. journals.sagepub.com. 20 (9): 1101. doi:10.1177/1087057115588287. PMID 26024946. Retrieved 2015-05-29.
- ↑ "Roche and Labcyte Integrate Echo and LightCycler Systems to Increase Performance of qPCR-based RNA/DNA Analyses". fiercepharma.com. Retrieved 2011-12-11.
- ↑ Harris, D; Olechno, J; Datwani, S; Ellson, R (2009). "Gradient, Contact-Free Volume Transfers Minimize Compound Loss in Dose-Response Experiments". Journal of Biomolecular Screening. journals.sagepub.com. 15 (1): 86–94. doi:10.1177/1087057109351027. PMID 20008122. Retrieved 2009-12-11.
- ↑ Agrawal, Sony; Cifelli, Steven; Johnstone, Richard; Pechter, David; Barbey, Deborah A; Lin, Karen; Allison, Tim; Agrawal, Shree; Rivera-Gines, Aida; Milligan, James A; Schneeweis, Jonathan; Houle, Kevin; Struck, Alice J; Visconti, Richard; Sills, Matthew; Wildey, Mary Jo (2016). "Utilizing Low-Volume Aqueous Acoustic Transfer with the Echo 525 to Enable Miniaturization of qRT-PCR Assay". Journal of Laboratory Automation. journals.sagepub.com. 21 (1): 57–63. doi:10.1177/2211068215609315. PMID 26460107. Retrieved 2015-10-12.
- ↑ "Echo 550 at DZNE". dzne.de.com. Retrieved 2018-02-20.
- ↑ "Labcyte Unveils Novel Acoustic Sample Management Platform". genengnews.com. Retrieved 2018-02-08.
- ↑ "Labcyte, AstraZeneca to Develop Acoustic Sample Handling Tech". dddmag.com. Retrieved 2013-09-25.
- ↑ "Titian's Mosaic sample management software optimizes integrating Labcyte's acoustic instrumentation with your screening workflows". technologynetworks.com. Retrieved 2017-02-17.
External Links[edit]
- Labcyte company website
- Labcyte on Bloomberg
- Labcyte on Crunchbase
- Labcyte on MIT Technology Review
- Publications on Echo acoustic liquid handling
- Labcyte and Genome Project-write
- Echo Liquid Handler at University College London
- Echo Liquid Handler at Duke University
- Echo Liquid Handler at Yale University
This article "Labcyte" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Labcyte. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
